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Volumn 7, Issue 12, 2012, Pages

Mice Deficient in Urokinase-Type Plasminogen Activator Have Delayed Healing of Tympanic Membrane Perforations

Author keywords

[No Author keywords available]

Indexed keywords

PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

EID: 84870940276     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051303     Document Type: Article
Times cited : (19)

References (34)
  • 1
    • 34447643611 scopus 로고    scopus 로고
    • Chronic tympanic membrane perforation: a better animal model is needed
    • Santa Maria PL, Atlas MD, Ghassemifar R, (2007) Chronic tympanic membrane perforation: a better animal model is needed. Wound Repair Regen 15: 450-458.
    • (2007) Wound Repair Regen , vol.15 , pp. 450-458
    • Santa Maria, P.L.1    Atlas, M.D.2    Ghassemifar, R.3
  • 2
    • 0036398303 scopus 로고    scopus 로고
    • Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application
    • Ma Y, Zhao H, Zhou X, (2002) Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application. Acta Otolaryngol 122: 586-599.
    • (2002) Acta Otolaryngol , vol.122 , pp. 586-599
    • Ma, Y.1    Zhao, H.2    Zhou, X.3
  • 3
    • 16844384895 scopus 로고    scopus 로고
    • Structure and function of the plasminogen/plasmin system
    • Castellino FJ, Ploplis VA, (2005) Structure and function of the plasminogen/plasmin system. Thromb Haemost 93: 647-654.
    • (2005) Thromb Haemost , vol.93 , pp. 647-654
    • Castellino, F.J.1    Ploplis, V.A.2
  • 4
    • 0041802737 scopus 로고    scopus 로고
    • Plasminogen activator/plasmin system: a major player in wound healing?
    • Li WY, Chong SS, Huang EY, Tuan TL, (2003) Plasminogen activator/plasmin system: a major player in wound healing? Wound Repair Regen 11: 239-247.
    • (2003) Wound Repair Regen , vol.11 , pp. 239-247
    • Li, W.Y.1    Chong, S.S.2    Huang, E.Y.3    Tuan, T.L.4
  • 5
    • 84862491710 scopus 로고    scopus 로고
    • Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds
    • Shen Y, Guo Y, Mikus P, Sulniute R, Wilczynska M, et al. (2012) Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood 119: 5879-5887.
    • (2012) Blood , vol.119 , pp. 5879-5887
    • Shen, Y.1    Guo, Y.2    Mikus, P.3    Sulniute, R.4    Wilczynska, M.5
  • 6
    • 0030007064 scopus 로고    scopus 로고
    • Impaired wound healing in mice with a disrupted plasminogen gene
    • Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, et al. (1996) Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med 2: 287-292.
    • (1996) Nat Med , vol.2 , pp. 287-292
    • Romer, J.1    Bugge, T.H.2    Pyke, C.3    Lund, L.R.4    Flick, M.J.5
  • 7
    • 0033199235 scopus 로고    scopus 로고
    • Functional overlap between two classes of matrix-degrading proteases in wound healing
    • Lund LR, Romer J, Bugge TH, Nielsen BS, Frandsen TL, et al. (1999) Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J 18: 4645-4656.
    • (1999) EMBO J , vol.18 , pp. 4645-4656
    • Lund, L.R.1    Romer, J.2    Bugge, T.H.3    Nielsen, B.S.4    Frandsen, T.L.5
  • 8
    • 0024146930 scopus 로고
    • Cell-associated plasminogen activation: regulation and physiological functions
    • Saksela O, Rifkin DB, (1988) Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol 4: 93-126.
    • (1988) Annu Rev Cell Biol , vol.4 , pp. 93-126
    • Saksela, O.1    Rifkin, D.B.2
  • 9
    • 33749829905 scopus 로고    scopus 로고
    • Plasmin/plasminogen is essential for the healing of tympanic membrane perforations
    • Li J, Eriksson PO, Hansson A, Hellstrom S, Ny T, (2006) Plasmin/plasminogen is essential for the healing of tympanic membrane perforations. Thromb Haemost 96: 512-519.
    • (2006) Thromb Haemost , vol.96 , pp. 512-519
    • Li, J.1    Eriksson, P.O.2    Hansson, A.3    Hellstrom, S.4    Ny, T.5
  • 11
    • 28144464615 scopus 로고    scopus 로고
    • Fresh tympanic membrane perforations heal without significant loss of strength
    • Rahman A, Hultcrantz M, Dirckx J, Margolin G, von Unge M, (2005) Fresh tympanic membrane perforations heal without significant loss of strength. Otol Neurotol 26: 1100-1106.
    • (2005) Otol Neurotol , vol.26 , pp. 1100-1106
    • Rahman, A.1    Hultcrantz, M.2    Dirckx, J.3    Margolin, G.4    von Unge, M.5
  • 12
    • 34547755473 scopus 로고    scopus 로고
    • Structural and functional properties of the healed tympanic membrane: a long-term follow-up after laser myringotomy
    • Rahman A, Hultcrantz M, Dirckx J, von Unge M, (2007) Structural and functional properties of the healed tympanic membrane: a long-term follow-up after laser myringotomy. Otol Neurotol 28: 685-691.
    • (2007) Otol Neurotol , vol.28 , pp. 685-691
    • Rahman, A.1    Hultcrantz, M.2    Dirckx, J.3    von Unge, M.4
  • 13
    • 0029952542 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator
    • Bugge TH, Flick MJ, Danton MJ, Daugherty CC, Romer J, et al. (1996) Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc Natl Acad Sci U S A 93: 5899-5904.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5899-5904
    • Bugge, T.H.1    Flick, M.J.2    Danton, M.J.3    Daugherty, C.C.4    Romer, J.5
  • 14
    • 77956561594 scopus 로고    scopus 로고
    • Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
    • Connolly BM, Choi EY, Gardsvoll H, Bey AL, Currie BM, et al. (2010) Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood 116: 1593-1603.
    • (2010) Blood , vol.116 , pp. 1593-1603
    • Connolly, B.M.1    Choi, E.Y.2    Gardsvoll, H.3    Bey, A.L.4    Currie, B.M.5
  • 15
    • 77958563278 scopus 로고    scopus 로고
    • Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice
    • Jogi A, Rono B, Lund IK, Nielsen BS, Ploug M, et al. (2010) Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. PLoS One 5: e12746.
    • (2010) PLoS One , vol.5
    • Jogi, A.1    Rono, B.2    Lund, I.K.3    Nielsen, B.S.4    Ploug, M.5
  • 16
    • 57349133779 scopus 로고    scopus 로고
    • Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice
    • Prestwich AH, Li J, Eriksson PO, Ny T, Berggren D, et al. (2008) Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice. Acta Otolaryngol 128: 1294-1302.
    • (2008) Acta Otolaryngol , vol.128 , pp. 1294-1302
    • Prestwich, A.H.1    Li, J.2    Eriksson, P.O.3    Ny, T.4    Berggren, D.5
  • 18
    • 33745541642 scopus 로고    scopus 로고
    • Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice
    • Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, et al. (2006) Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J 25: 2686-2697.
    • (2006) EMBO J , vol.25 , pp. 2686-2697
    • Lund, L.R.1    Green, K.A.2    Stoop, A.A.3    Ploug, M.4    Almholt, K.5
  • 19
    • 0023946446 scopus 로고
    • Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo
    • Grondahl-Hansen J, Lund LR, Ralfkiaer E, Ottevanger V, Dano K, (1988) Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo. J Invest Dermatol 90: 790-795.
    • (1988) J Invest Dermatol , vol.90 , pp. 790-795
    • Grondahl-Hansen, J.1    Lund, L.R.2    Ralfkiaer, E.3    Ottevanger, V.4    Dano, K.5
  • 22
    • 0034604635 scopus 로고    scopus 로고
    • Urinary-type plasminogen activator (uPA) expression and uPA receptor localization are regulated by alpha 3beta 1 integrin in oral keratinocytes
    • Ghosh S, Brown R, Jones JC, Ellerbroek SM, Stack MS, (2000) Urinary-type plasminogen activator (uPA) expression and uPA receptor localization are regulated by alpha 3beta 1 integrin in oral keratinocytes. J Biol Chem 275: 23869-23876.
    • (2000) J Biol Chem , vol.275 , pp. 23869-23876
    • Ghosh, S.1    Brown, R.2    Jones, J.C.3    Ellerbroek, S.M.4    Stack, M.S.5
  • 23
    • 0035653636 scopus 로고    scopus 로고
    • Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase
    • Tchougounova E, Pejler G, (2001) Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase. FASEB J 15: 2763-2765.
    • (2001) FASEB J , vol.15 , pp. 2763-2765
    • Tchougounova, E.1    Pejler, G.2
  • 25
    • 33947321575 scopus 로고    scopus 로고
    • uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view
    • Binder BR, Mihaly J, Prager GW, (2007) uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. Thromb Haemost 97: 336-342.
    • (2007) Thromb Haemost , vol.97 , pp. 336-342
    • Binder, B.R.1    Mihaly, J.2    Prager, G.W.3
  • 26
    • 40549144823 scopus 로고    scopus 로고
    • Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis
    • Guo Y, Li J, Hagstrom E, Ny T, (2008) Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis. Arthritis Rheum 58: 764-772.
    • (2008) Arthritis Rheum , vol.58 , pp. 764-772
    • Guo, Y.1    Li, J.2    Hagstrom, E.3    Ny, T.4
  • 27
    • 84865511829 scopus 로고    scopus 로고
    • Plasmin as a proinflammatory cell activator
    • Syrovets T, Lunov O, Simmet T, (2012) Plasmin as a proinflammatory cell activator. J Leukoc Biol 92: 509-19.
    • (2012) J Leukoc Biol , vol.92 , pp. 509-519
    • Syrovets, T.1    Lunov, O.2    Simmet, T.3
  • 28
    • 0034254823 scopus 로고    scopus 로고
    • Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection
    • Gyetko MR, Sud S, Kendall T, Fuller JA, Newstead MW, et al. (2000) Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol 165: 1513-1519.
    • (2000) J Immunol , vol.165 , pp. 1513-1519
    • Gyetko, M.R.1    Sud, S.2    Kendall, T.3    Fuller, J.A.4    Newstead, M.W.5
  • 29
    • 0028295979 scopus 로고
    • Physiological consequences of loss of plasminogen activator gene function in mice
    • Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, et al. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368: 419-424.
    • (1994) Nature , vol.368 , pp. 419-424
    • Carmeliet, P.1    Schoonjans, L.2    Kieckens, L.3    Ream, B.4    Degen, J.5
  • 30
    • 0035298106 scopus 로고    scopus 로고
    • uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration
    • Legrand C, Polette M, Tournier JM, de Bentzmann S, Huet E, et al. (2001) uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res 264: 326-336.
    • (2001) Exp Cell Res , vol.264 , pp. 326-336
    • Legrand, C.1    Polette, M.2    Tournier, J.M.3    de Bentzmann, S.4    Huet, E.5
  • 31
    • 0029970958 scopus 로고    scopus 로고
    • Protein kinase C mediates up-regulation of urokinase and its receptor in the migrating keratinocytes of wounded cultures, but urokinase is not required for movement across a substratum in vitro
    • Ando Y, Jensen PJ, (1996) Protein kinase C mediates up-regulation of urokinase and its receptor in the migrating keratinocytes of wounded cultures, but urokinase is not required for movement across a substratum in vitro. J Cell Physiol 167: 500-511.
    • (1996) J Cell Physiol , vol.167 , pp. 500-511
    • Ando, Y.1    Jensen, P.J.2
  • 32
    • 33750007162 scopus 로고    scopus 로고
    • Spontaneous development of otitis media in plasminogen-deficient mice
    • Eriksson PO, Li J, Ny T, Hellstrom S, (2006) Spontaneous development of otitis media in plasminogen-deficient mice. Int J Med Microbiol 296: 501-509.
    • (2006) Int J Med Microbiol , vol.296 , pp. 501-509
    • Eriksson, P.O.1    Li, J.2    Ny, T.3    Hellstrom, S.4
  • 34
    • 80052634562 scopus 로고    scopus 로고
    • Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice
    • Guo Y, Li J, Hagstrom E, Ny T, (2011) Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice. PLoS One 6: e24774.
    • (2011) PLoS One , vol.6
    • Guo, Y.1    Li, J.2    Hagstrom, E.3    Ny, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.