Plasmin/plasminogen is essential for the healing of tympanic membrane perforations

Thrombosis and Haemostasis

Volumn 96, Issue 4, 2006, Pages 512-519

  Li, Jinan ^a   Eriksson, Per Olof ^a   Hansson, Annika ^a   Hellström, Sten ^a   Ny, Tor ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Inflammation; Neutrophils; Plasmin; Tympanic membrane; Wound healing

Indexed keywords

FIBRIN; PLASMIN; PLASMINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONNECTIVE TISSUE; CONTROLLED STUDY; DEBRIDEMENT; EARDRUM PERFORATION; EPITHELIZATION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; KERATINOCYTE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; TISSUE GROWTH; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANIMALS; CELL PROLIFERATION; FIBRIN; KERATINOCYTES; KERATINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; PLASMIN; PLASMINOGEN; TIME FACTORS; TYMPANIC MEMBRANE PERFORATION; WOUND HEALING;

EID: 33749829905     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-03-0168     Document Type: Article

References (40)

1. Saksela O, Rifkin DB. Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol 1988; 4: 93-126.
2. Romer J, Bugge TH, Pyke C, et al. Impaired wound healing in mice with a disrupted plasminogen gene [see comments]. Nat Med 1996; 2: 287-92.
3. Luttun A, Dewerchin M, Collen D, et al. The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies. Curr Atheroscler Rep 2000; 2: 407-16.
4. Pintucci G, Bikfalvi A, Klein S, et al. Angiogenesis and the fibrinolytic system. Semin Thromb Hemost 1996; 22: 517-24.
5. Andreasen PA, Kjoller L, Christensen L, et al. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997; 72: 1-22.
6. Bajou K, Noel A, Gerard RD, et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med 1998; 4: 923-8.
7. Sandstrom M, Johansson M, Sandstrom J, et al. Expression of the proteolytic factors, tPA and uPA, PAI-1 and VEGF during malignant glioma progression. Int J Dev Neurosci 1999; 17: 473-81.
8. Ny T, Peng XR, and Ohlsson M. Hormonal regulation of the fibrinolytic components in the ovary. Thromb Res 1993; 71: 1-45.
9. Hellstrom S, Spratley J, Eriksson PO, et al. Tympanic membrane vessel revisited: a study in an animal model. Otol Neurotol 2003; 24: 494-9.
10. Albiin N, Hellstrom S, Salen B, et al. The vascular supply of the rat tympanic membrane. Anat Rec 1985; 212: 17-22.
11. Goldie P, Hellstrom S. Identification and characterization of middle ear vascular leakage sites in experimental otitis media. Ann Otol Rhinol Laryngol 1990; 99: 810-6.
12. Bluestone CD. Clinical course, complications and sequelae of acute otitis media. Pediatr Infect Dis J 2000; 19: S37-S46.
13. Teele DW, Lundgren K, Casselbrant ML, et al. Recent advances in otitis media. Epidemiology and natural history. Ann Otol Rhinol Laryngol Suppl 1989; 139: 11-3.
14. Mattsson C, Johansson C, and Hellstrom S. Myringosclerosis develops within 9h of myringotomy. ORL J Otorhinolaryngol Relat Spec 1999; 61: 31-6.
15. Stenfors LE, Carlsoo B, Salen B, et al. Repair of experimental tympanic membrane perforations. Acta Otolaryngol 1980; 90: 332-41.
16. Boedts D. Tympanic membrane perforations. Acta Otorhinolaryngol Belg 1995; 49: 149-58.
17. Bugge TH, Flick MJ, Daugherty CC, et al. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev 1995; 9: 794-807.
18. Ploplis VA, Carmeliet P, Vazirzadeh S, et al. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 1995; 92: 2585-93.
19. Drew AF, Schiman HL, Kombrinck KW, et al. Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice. Invest Ophthalmol Vis Sci 2000; 41: 67-72.
20. Kao WW, Kao CW, Kaufman AH, et al. Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice. Invest Ophthalmol Vis Sci 1998; 39: 502-8.
21. Creemers E, Cleutjens J, Smits J, et al. Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am J Pathol 2000; 156: 1865-73.
22. Carmeliet P, Moons L, Ploplis V, et al. Impaired arterial neointima formation in mice with disruption of the plasminogen gene. J Clin Invest 1997; 99: 200-8.
23. Drew AF, Tucker HL, Kombrinck KW, et al. Plasminogen is a critical determinant of vascular remodeling in mice. Circ Res 2000; 87: 133-9.
24. Bezerra JA, Bugge TH, Melin-Aldana H, et al. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci USA 1999; 96: 15143-8.
25. Suelves M, Lopez-Alemany R, Lluis F, et al. Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. Blood 2002; 99: 2835-44.
26. Lund LR, Romer J, Bugge TH, et al. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J 1999; 18: 4645-56.
27. Spratley J, Hellstrom S, Eriksson PO, et al. Early structural tympanic membrane reactions to myringotomy: a study in an acute otitis media model. Acta Otolaryngol 2002; 122: 479-87.
28. Mondain M, Ryan A. Histological study of the healing of traumatic tympanic membrane perforation after basic fibroblast growth factor application. Laryn- goscope 1993; 103: 312-8.
29. Ny A, Leonardsson G, Hagglund AC, et al. Ovulation in plasminogen-deficient mice. Endocrinology 1999; 140: 5030-5.
30. Eriksson PO, Mattsson C, and Hellstrom S. First forty-eight hours of developing otitis media: an experimental study. Ann Otol Rhinol Laryngol 2003; 112: 558-66.
31. Ny T, Wahlberg P, and Brandstrom, U. Matrix remodeling in the ovary: regulation and functional role of the plasminogen activator and matrix metalloproteinase systems. Mol Cell Endocrinol 2002; 187: 29-38.
32. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 2004; 9: 283-9.
33. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341: 738-46.
34. McIntire C, Benitez JT. Spontaneous repair of the tympanic membrane. Histpathological studies in the cat. Ann Otol Rhinol Laryngol 1970; 79: 1129-31.
35. Hellstrom S, Bloom GD, Berghem L, et al. A comparison of hyaluronan and fibronectin in the healing of tympanic membrane perforations. Eur Arch Otorhinolaryngol 1991; 248: 230-5.
36. Vassalli JD, Saurat JH. Cuts and scrapes? Plasmin heals! Nat Med 1996; 2: 284-5.
37. Li WY, Chong SS, Huang EY, et al. Plasminogen activator/plasmin system: a major player in wound healing? Wound Repair Regen 2003; 11: 239-47.
38. Schott D, Dempfle CE, Beck P, et al. Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. N Engl J Med 1998; 339: 1679-86.
39. Dykes DD, Mount M, and Polesky HF. Parentage testing using the serum protein plasminogen (PLG). Am J Clin Pathol 1984; 82: 722-5.
40. Nishimukai H, Kera Y, Sakata K, et al. Genetic polymorphism of plasminogen: a new basic variant (PLG B) and population study in Japanese. Vox Sang 1981; 40: 422-5.