Anti-inflammatory and antimicrobial activity of 4,5-dihydropyrimidine-5- carbonitrile derivatives: Their synthesis and spectral elucidation

Acta Poloniae Pharmaceutica - Drug Research

Volumn 69, Issue 6, 2012, Pages 1077-1085

  Alam, Mohammad Mumtaz ^a   Akhter, Mymoona ^a   Husain, Asif ^a   Marella, Akranth ^a   Tanwar, Om Prakash ^a   Ali, Rahmat ^a   Hasan, Syed Misbahul ^b   Kumar, Harish ^c   Haider, Rashiduddin ^d   Shaquiquzzaman, Mohammad ^a  

^a HAMDARD UNIVERSITY   (India)

^b JOUF UNIVERSITY   (Saudi Arabia)

^c RANBAXY RESEARCH LABORATORIES   (India)

^d VEER KUNWAR SINGH UNIVERSITY   (India)

Author keywords

Analgesic; Anti inflammatory; Antimicrobial; Cyanopyrimidine; Schiff's base

Indexed keywords

2 HYDRAZINYL 4 (1 H INDOLE 2 YL) 6 OXO 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 2 MERCAPTO 4 (1 H INDOLE 2 YL) 6 OXO 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (1 H INDOLE 2 YL) 4 OXO 2 [2 (2,6 DICHLOROBENZYLIDENE)HYDRAZINYL] 4,5 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (1H INDOL 2 YL) 4 OXO 2 [2 (2 CHLOROBENZYLIDENE)HYDRAZINYL] 4,5 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (1H INDOL 2 YL) 4 OXO 2 [2 (3,4 DIMETHOXYBENZYLIDENE) HYDRAZINYL]4,5 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (1H INDOL 2 YL) 4 OXO 2 [2 (4 BROMO BENZYLIDENE)HYDRAZINYL) 4,5 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (1H INDOL 2 YL) 4 OXO 2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL] 4,5 DIHYDROPYRIMIDINE 5 CARBONITRILE; ACETIC ACID; ALCOHOL; CYANIDE; FLUCONAZOLE; HYDRAZINE; HYDRAZONE DERIVATIVE; INDOMETACIN; NORFLOXACIN; NUCLEOPHILE; THIOUREA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIGINELLI REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL STRAIN; MOUSE; NONHUMAN; PAW EDEMA; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; FEMALE; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PYRIMIDINES; RATS; RATS, WISTAR;

EID: 84870926534     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Radwan M.A.A., Ragab E.A., Sabry N.M., EIShenawy S.M.: Bioorg. Med. Chem. 15, 3832 (1979).
2. Dubey P.K., Venkateshwar T., Reddanna P., Kumar A.: Indian J. Chem. 45B, 2128 (2006).
3. Sakhuja R., Panda S.S., Khanna L., Khurana S., Jain S.C.: Bioorg. Med. Chem. Lett. 21, 5465 (2011).
4. Kamaria P., Kawathekar N., Chaturvedi P.: e-J. Chem. 8, 305 (2011).
5. Panwar H., Verma R.S., Srivastava V.K., Kumar A.: Indian J. Chem. 45B, 2099 (2006).
6. Tiwari R.K., Singh D., Singh J., Yadav V., Pathak A.K., Dabur R., Chhillar A.K. et al.: Bioorg. Med. Chem. 16, 413 (2006).
7. Varvaresou A., Siatra-Papastaikoudi T., Tsotinis A., Tsantili-Kakoulidou A., Vamvakides A.: Farmaco 53, 320 (1998).
8. Kumar A., Kumar D., Akramand M., Kaur H.: Int. J. Pharm. Biol. Arch. 2, 744 (2011).
9. Guzel O., Karali N., Salman A.: Bioorg. Med. Chem. 16, 8976 (2008).
10. Kgokong J.L., Smith P.P., Matsabisa G.M.: Bioorg. Med. Chem. 13, 2935 (2005).
11. Weng J.R., Tsai C., Kulp S.K., Chen C.S.: Cancer Lett. 262, 153 (2008).
12. Zhang H., Derian C.K., Andrade-Gordon P., Hoekstra W.J., McComsey D.F., White K.B., Poulter B.L. et al.: J. Med. Chem. 44, 1021 (2001).
13. Vijaya Raj K.K., Naryana B., Ashalatha B.V.: J. Pharmacol. Toxicol. 6, 559 (2006).
14. Sondhi S.M., Jain S., Dinodia M., Shukla R., Raghubir R.: Bioorg. Med. Chem. 15, 3334 (2007).
15. Amir M., Javed S.A., Kumar H.: Indian J. Pharm. Sci. 69, 337 (2007).
16. Lee H.W., Kim B.Y., Ahn J.B., Kang S.K., Lee J.H., Shin J.S., Ahn S.K., Lee S.J., Yoon S.S.: Eur. J. Med. Chem. 40, 862 (2005).
17. Chen Q., Zhu X., Jiang L., Liu Z., Yang G.: Eur. J. Med. Chem. 43, 595 (2008).
18. Ghorab M.M., Ragab F.A., Alqasoumi S.I., Alafeefy A.M., Aboulmagd S.A.: Eur. J. Med. Chem. 45, 171 (2010).
19. Ivanov M.A., Ivanov A.V., Krasnitskaya I.A., Smirnova O.A., Karpenko I.L., Belanov E.F., Prasolov V.S. et al.: Russian J. Bioorg. Chem. 34, 593 (2008).
20. Mosaad S.M., Samir M.A., Amira I.S.: Molecules 15, 1882 (2010).
21. Mosaad S.M., Kamel R., Fatahala S.S.: Eur. J. Med. Chem. 45, 2994 (2010).
22. Akhter M., Husain A., Azad B., Ajmal M.: Eur. J. Med. Chem. 44, 2372 (2009).
23. Hasan S.M., Alam M.M., Husain A., Khanna S., Akhtar M., Zaman M.S.: Eur. J. Med. Chem. 44, 4896 (2009).
24. Winter C.A., Risley E.A., Nuss G.N.: Proc. Soc. Exp. Biol. 111, 544 (1962).
25. Seigmund E., Cadmus R., Lu G.: Proc. Soc. Exp. Biol. 95, 729 (1957).
26. Cioli V., Putzolu S., Rossi V., Sorza Barcellona P., Corradino C.: Toxicol. Appl. Pharmacol. 50, 283 (1979).
27. Cruickshank R., Dugid J.P., Marmion D.P., Swain R.H.A.: Medical Microbiology, vol. 2, Churchill-Livingstone, Edinburgh, London 1975.