Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Volumn 45, Issue 9, 2006, Pages 2128-2132

  Dubey, P K ^a   Kumar, T Venkateshwar ^a   Reddanna, P ^b   Kumar, K Anil ^b  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

Acrylic acid methylester; Benzoxazinone; COX 2 inihibitors; Indole acetic acid; Inflammation

Indexed keywords

EID: 33750333266     PISSN: 03764699     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Parfitt K, Martindale-The Complete Drug Reference, Pharmaceutical Press, 32, 1999, 1010.
2. (a) Kargman S, Wong E, Greig G M, Falgueyret J P, Cromlish W, Ethier, D, Yergey J A, Reindean D, Evans J F, Kennedy B, Tagari P, Francis D & Neill G P O, Biochem Pharmacol, 52, 1996, 1113.
3. (b) Bridean C, Kargman S, Dallob A L, Enrich E W, Rodger I W & Chan C C, Inflamm Res, 45, 1996, 68.
4. Richardson C & Emery P, Drug safety, 15, 1996, 249.
5. Talley J J, Bertenshaw S R, Brown D L, Carter J, Graneto M J, Kellogg M S, Koboldt C M, Yuan J, Zhang Y Y & Seibort K, J Med Chem, 43, 2000, 1661.
6. Ducharme Y, Gauthier J Y, Prasit P, Leblanc Y, Wang Z, Leger S & Therien M, WO Patent, 9518799, 1995; Chem Abstr, 124, 1996, 201998.
7. Talley J J, Brown D L, Carter J S, Graneto M J, Koboldt C M, Masferrer J L, Perkins W E, Rogers R S, Shaffer A F, Zhang Y Y, Zweifel B S & Seibert K, J Med Chem, 43, 2000, 775.
8. Reindeau D, Percival M D, Bridean C, Charleson S, Dube D, Ethier D, Falgueyret J P, Friesen R W, Gordon R, Greig G, Guay J, Mancini J, Oellet M, Wong E, Xu L, Boycc S, Visco D, Girard Y, Prasit P, Zamboni R, Rodger J W, Gresser M, Ford Hutchinsons A W, Young R N & Can C C, J Pharmacol Exp Ther, 296, 2001, 558.
9. Venkateshwar Kumar T, Srinivasa Rao K, Laxminarayana V, Aparna V & Dubey P K, Heterocycl Commun, 9, 2003, 51.
10. Caron S, Vazquez E, Stevens R W, Nakao K, Koike H & Murata Y, J Org Chem, 68, 2003, 4104.
11. Reddy Sastry C V, Srinivasa Rao K, Rastogi K & Jain M L, Indian J Chem, 27B, 1988, 290.
12. Copeland R A, Williams J M, Giannars J, Nurnberg S, Covington M, Pinto D, Pick S & Trzaskos J M, Proc Natl Acad Sci USA, 91, 1994, 11202.
13. Brackeen M F, Stafford J A, Cowan D J, Brown P J, Domanico P L, Feldman P L, Rose D, Strickland A B, Veal J M & Verghese M, J Med Chem, 38, 1995, 4848.