Site-directed PEGylation as successful approach to improve the enzyme replacement in the case of prolidase

International Journal of Pharmaceutics

Volumn 358, Issue 1-2, 2008, Pages 230-237

  Colonna, C ^a   Conti, B ^a   Perugini, P ^a   Pavanetto, F ^a   Modena, T ^a   Dorati, R ^a   Iadarola, P ^b   Genta, I ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Chitosan nanoparticles; Enzyme replacement therapy; Enzyme stability; Prolidase deficiency; Site directed PEGylation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CHITOSAN; CHITOSAN GLUTAMATE; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL MALEIMIDE; PROLINE DIPEPTIDASE; PROTASAN;

ARTICLE; BIODEGRADABILITY; CELL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DEGRADATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENCAPSULATION; ENZYME ACTIVITY; ENZYME REPLACEMENT; EX VIVO STUDY; FIBROBLAST; HUMAN; HUMAN CELL; INCUBATION TEMPERATURE; INCUBATION TIME; MOLECULAR WEIGHT; PARTICLE SIZE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TOXICITY TESTING; ZETA POTENTIAL;

CELL SURVIVAL; CELLS, CULTURED; DIPEPTIDASES; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; HUMANS; MALEIMIDES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; POLYETHYLENE GLYCOLS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

EID: 44449150161     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.012     Document Type: Article

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