Inhibitory effect of simulated microgravity on differentiating preosteoblasts

Advances in Space Research

Volumn 51, Issue 1, 2013, Pages 107-114

  Hu, L F ^a   Qian, A R ^a   Wang, Y ^a   Di, S M ^a   Shang, P ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

Bone loss; Osteoblast differentiation; Random positioning machine; Simulated microgravity

Indexed keywords

ACTIVATION ANALYSIS; BONE; ELECTROPHORESIS; ENZYME ACTIVITY; GENE EXPRESSION; MICROGRAVITY PROCESSING; OSTEOBLASTS; PHOSPHATASES; UNLOADING;

ALKALINE PHOSPHATASE ACTIVITY; BONE LOSS; BONE MORPHOGENETIC PROTEINS; EXTRACELLULAR SIGNAL-REGULATED KINASE; OSTEOBLAST DIFFERENTIATION; RANDOM POSITIONING; SIMULATED MICROGRAVITY; WESTERN-BLOT ANALYSIS;

MICROGRAVITY;

EID: 84870915926     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2012.07.036     Document Type: Article

References (46)

1. S.A. Bloomfield Disuse osteopenia Curr. Osteoporos. Rep. 8 2010 91 97
2. A. Caillot-Augusseau, M.H. Lafage-Proust, and C. Soler Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95) Clin. Chem. 44 1998 578 585
3. A. Caillot-Augusseau, L. Vico, and M. Heer Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts Clin. Chem. 46 2000 1136 1143
4. G. Carmeliet, G. Nys, and R. Bouillon Microgravity reduces the differentiation of human osteoblastic MG-63 cells J. Bone Miner. Res. 12 1997 786 794
5. G. Carmeliet, L. Vico, and R. Bouillon Space flight: a challenge for normal bone homeostasis Crit. Rev. Eukaryot. Gene. Expr. 11 2001 131 144
6. P. Collet, D. Uebelhart, and L. Vico Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans Bone 20 1997 547 551
7. S.M. Di, A.R. Qian, and L.N. Qu Graviresponses of osteocytes under altered gravity Adv. Space. Res. 48 2011 1161 1166
8. P. Ducy, R. Zhang, and V. Geoffroy Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747 754
9. L.A. Ehrlich, H.Y. Chung, and I. Ghobrial IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma Blood 106 2005 1407 1414
10. R.T. Franceschi, and G. Xiao Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways J. Cell. Biochem. 88 2003 446 454
11. L.P. Garetto, M.R. Gonsalves, and E.R. Morey Preosteoblast production 55 hours after a 12.5-day spaceflight on Cosmos 1887 FASEB. J. 4 1990 24 28
12. C. Ge, G. Xiao, and D. Jiang Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development J. Cell. Biol. 176 2007 709 718
13. N. Ghosh-Choudhury, C.C. Mandal, and G.G. Choudhury Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation J. Biol. Chem. 282 2007 4983 4993
14. T.G. Hammond, and J.M. Hammond Optimized suspension culture: the rotating-wall vessel AM. J. Physiol. Renal. Physiol. 281 2001 F12 F25
15. C. Higuchi, A. Myoui, and N. Hashimoto Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix J. Bone Miner. Res. 17 2002 1785 1794
16. J.H. Keyak, A.K. Koyama, and A. LeBlanc Reduction in proximal femoral strength due to long-duration spaceflight Bone 44 2009 449 453
17. T. Komori, H. Yagi, and S. Nomura Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Cell 89 1997 755 764
18. W.X. Kong, H. Zhu, and X.X. Jiang Involvement of MAPK pathway in the osteoblastic differentiation of mouse mesenchymal stem cells Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18 2010 981 985
19. S.J. Kono, Y. Oshima, and K. Hoshi Erk pathways negatively regulate matrix mineralization Bone 40 2007 68 74
20. T. Lang, A. LeBlanc, and H. Evans Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight J. Bone Miner. Res. 19 2004 1006 1012
21. -ΔΔCT method Methods 25 2001 402 408
22. M.Z. Luo, R. Meng, and S.S. Li Weightlessness simulated with random positioning machine influences the cytoskeleton and migration of MC3T3-E1 cells J. Jpn. Soc. Microgravity. Appl. 28 2011 S41 S45
23. T. Matsubara, K. Kida, and A. Yamaguchi BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation J. Biol. Chem. 283 2008 29119 29125
24. T. Matsushita, Y.Y. Chan, and A. Kawanami Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis Mol. Cell. Biol. 29 2009 5843 5857
25. E.R. Morey, and D.J. Baylink Inhibition of bone formation during space flight Science 201 1978 1138 1141
26. K. Nakashima, and B. de Crombrugghe Transcriptional mechanisms in osteoblast differentiation and bone formation Trends. Genet. 19 2003 458 466
27. K. Nakashima, X. Zhou, and G. Kunkel The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation Cell 108 2002 17 29
28. K. Nakayama, Y. Tamura, and M. Suzawa Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-E1 osteoblast-like cells J. Bone Miner. Res. 18 2003 827 835
29. V.S. Oganov Modern analysis of bone loss mechanisms in microgravity J. Gravit. Physiol. 11 2004 P143 P146
30. C. Ontiveros, and L.R. McCabe Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation J. Cell. Biochem. 88 2003 427 437
31. D.J. Papachristou, K.K. Papachroni, and E.K. Basdra Signaling networks and transcription factors regulating mechanotransduction in bone Bioessays 31 2009 794 804
32. S.J. Pardo, M.J. Patel, and M.C. Sykes Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts Am. J. Physiol. Cell. Physiol. 288 2005 C1211 C1221
33. A.R. Qian, D.C. Yin, and P.F. Yang Development of a ground-based simulated experimental platform for gravitational biology IEEE. T. Appl. Supercon. 19 2009 42 46
34. D. Shi, R. Meng, and W. Deng Effects of microgravity modeled by large gradient high magnetic field on the osteogenic initiation of human mesenchymal stem cells Stem Cell. Rev. 6 2010 567 578
35. Sun, Y., Shuang, F., Chen, D.M., et al. Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos. Int. PMID: 22648000, 2012.
36. R.T. Turner, G.L. Evans, and G.K. Wakley Spaceflight results in depressed cancellous bone formation in rat humeri Aviat. Space. Environ. Med. 66 1995 770 774
37. J.J. van Loon Some history and use of the random positioning machine, RPM, in gravity related research Adv. Space. Res. 39 2007 1161 1165
38. J. Vernikos Human physiology in space Bioessays 18 1996 1029 1037
39. J. Vernikos, and V.S. Schneider Space, gravity and the physiology of aging: parallel or convergent disciplines? a mini-review Gerontology 56 2010 157 166
40. L. Vico, P. Collet, and A. Guignandon Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts Lancet 355 2000 1607 1611
41. L. Xiang, F. Qi, and D. Dai Simulated microgravity affects growth of Escherichia coli and recombinant beta-D-glucuronidase production Appl. Biochem. Biotechnol. 162 2010 654 661
42. G. Xiao, D. Jiang, and P. Thomas MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1 J. Biol. Chem. 275 2000 4453 4459
43. G. Xiao, R. Gopalakrishnan, and D. Jiang Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells J. Bone Miner. Res. 17 2002 101 110
44. A. Yamaguchi, T. Komori, and T. Suda Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1 Endocr. Rev. 21 2000 393 411
45. E. Zerath, X. Holy, and S.G. Roberts Spaceflight inhibits bone formation independent of corticosteroid status in growing rats J. Bone Miner. Res. 15 2000 1310 1320
46. P.G. Ziros, A.P. Gil, and T. Georgakopoulos The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells J. Biol. Chem. 277 2002 23934 23941