Urinary proteome analysis of irritable bowel syndrome (IBS) symptom subgroups

Journal of Proteome Research

Volumn 11, Issue 12, 2012, Pages 5650-5662

  Goo, Young Ah ^a   Cain, Kevin ^a   Jarrett, Monica ^a   Smith, Lynne ^a   Voss, Joachim ^a   Tolentino, Ernie ^a   Tsuji, Joyce ^a   Tsai, Yihsuan S ^a   Panchaud, Alexandre ^b   Goodlett, David R ^a   Shulman, Robert J ^c   Heitkemper, Margaret ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

biomarker; irritable bowel syndrome; mass spectrometry; proteomics; urine; women

Indexed keywords

CREATININE; PROTEOME;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DISTRESS SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IRRITABLE COLON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMICS; URINALYSIS; URINE;

ABDOMINAL PAIN; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; CONSTIPATION; CREATININE; DIARRHEA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GELSOLIN; HUMANS; INFLAMMATION; INTESTINES; IRRITABLE BOWEL SYNDROME; PEPTIDES; PROTEOME; SEVERITY OF ILLNESS INDEX; TANDEM MASS SPECTROMETRY;

LOTUS;

EID: 84870909465     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3004437     Document Type: Article

References (69)

1. Brandt, L. J.; Chey, W. D.; Foxx-Orenstein, A. E.; Schiller, L. R.; Schoenfeld, P. S.; Spiegel, B. M.; Talley, N. J.; Quigley, E. M. An evidence-based position statement on the management of irritable bowel syndrome Am. J. Gastroenterol. 2009, 104 (Suppl 1) S1-35
2. Yoon, S. L.; Grundmann, O.; Koepp, L.; Farrell, L. Management of irritable bowel syndrome (IBS) in adults: conventional and complementary/ alternative approaches Altern. Med. Rev. 2011, 16 (2) 134-51
3. Rey, E.; Talley, N. J. Irritable bowel syndrome: novel views on the epidemiology and potential risk factors Dig. Liver Dis. 2009, 41 (11) 772-80
4. Jerndal, P.; Ringstrom, G.; Agerforz, P.; Karpefors, M.; Akkermans, L. M.; Bayati, A.; Simren, M. Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS Neurogastroenterol. Motil. 2010, 22 (6 646-e179
5. DiBonaventura, M.; Sun, S. X.; Bolge, S. C.; Wagner, J. S.; Mody, R. Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome Curr. Med. Res. Opin. 2011, 27 (11) 2213-22
6. Suarez-Hitz, K. A.; Otto, B.; Bidlingmaier, M.; Schwizer, W.; Fried, M.; Ehlert, U. Altered psychobiological responsiveness in women with irritable bowel syndrome Psychosom. Med. 2012, 74 (2) 221-31
7. Barrett, J. S.; Gibson, P. R. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? Ther. Adv. Gastroenterol. 2012, 5 (4) 261-8
8. Camilleri, M.; Katzka, D. A. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome Am. J. Physiol.: Gastrointest. Liver Physiol. 2012, 302 (10) G1075-84
9. Martinez, C.; Vicario, M.; Ramos, L.; Lobo, B.; Mosquera, J. L.; Alonso, C.; Sanchez, A.; Guilarte, M.; Antolin, M.; de Torres, I.; Gonzalez-Castro, A. M.; Pigrau, M.; Saperas, E.; Azpiroz, F.; Santos, J. The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations Am. J. Gastroenterol. 2012, 107 (5) 736-46
10. Spiller, R.; Lam, C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome J. Neurogastroenterol. Motil. 2012, 18 (3) 258-68
11. Stasi, C.; Rosselli, M.; Bellini, M.; Laffi, G.; Milani, S. Altered neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model J Gastroenterol 2012, 10.1007/s00535-012-0627-7
12. Gozal, D.; Jortani, S.; Snow, A. B.; Kheirandish-Gozal, L.; Bhattacharjee, R.; Kim, J.; Capdevila, O. S. Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea Am. J. Respir. Crit. Care Med. 2009, 180 (12) 1253-61
13. Goo, Y. A.; Tsai, Y. S.; Liu, A. Y.; Goodlett, D. R.; Yang, C. C. Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: a pilot study. Int. Braz. J. Urol. 2010, 36 (4), 464-78, discussion 478-9.
14. Goo, Y. A.; Goodlett, D. R. Advances in proteomic prostate cancer biomarker discovery J. Proteomics 2010, 73 (10) 1839-50
15. Pollard, C.; Nitz, M.; Baras, A.; Williams, P.; Moskaluk, C.; Theodorescu, D. Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy Am. J. Pathol. 2009, 175 (5) 1824-30
16. Matheson, A.; Willcox, M. D.; Flanagan, J.; Walsh, B. J. Urinary biomarkers involved in type 2 diabetes: a review Diabetes/Metab. Res. Rev. 2010, 26 (3) 150-71
17. Heitkemper, M.; Jarrett, M.; Burr, R.; Cain, K. C.; Landis, C.; Lentz, M.; Poppe, A. Subjective and objective sleep indices in women with irritable bowel syndrome Neurogastroenterol. Motil. 2005, 17 (4) 523-30
18. Jarrett, M. E.; Cain, K. C.; Burr, R. L.; Hertig, V. L.; Rosen, S. N.; Heitkemper, M. M. Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions Am. J. Gastroenterol. 2009, 104 (12) 3004-14
19. Cain, K. C.; Jarrett, M. E.; Burr, R. L.; Rosen, S.; Hertig, V. L.; Heitkemper, M. M. Gender differences in gastrointestinal, psychological, and somatic symptoms in irritable bowel syndrome Dig. Dis. Sci. 2009, 54 (7) 1542-9
20. Voss, J.; Goo, Y. A.; Cain, K.; Woods, N.; Jarrett, M.; Smith, L.; Shulman, R.; Heitkemper, M. Searching for the noninvasive biomarker holy grail: are urine proteomics the answer? Biol. Res. Nurs. 2011, 13 (3) 235-42
21. Derogatis, L. BSI: Brief Symptom Inventory; Administration, Scoring and Procedures Manual, 4 th ed.; National Computer Systems: Minneapolis, MN, 1993.
22. Drossman, D.; Corazziari, E.; Talley, N., Eds. Rome II: The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology, and Treatment: A Multinational Consensus, 2 nd ed.; Degnon Associates: McLean, VA, 2000.
23. Jarrett, M. E.; Burr, R. L.; Cain, K. C.; Rothermel, J. D.; Landis, C. A.; Heitkemper, M. M. Autonomic nervous system function during sleep among women with irritable bowel syndrome Dig. Dis. Sci. 2008, 53 (3) 694-703
24. Burr, R. L.; Jarrett, M. E.; Cain, K. C.; Jun, S. E.; Heitkemper, M. M. Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome Neurogastroenterol. Motil. 2009, 21 (11) 1148-e97
25. Panchaud, A.; Scherl, A.; Shaffer, S. A.; von Haller, P. D.; Kulasekara, H. D.; Miller, S. I.; Goodlett, D. R. Precursor acquisition independent from ion count: how to dive deeper into the proteomics ocean Anal. Chem. 2009, 81 (15) 6481-8
26. Liu, H.; Sadygov, R. G.; Yates, J. R., III. A model for random sampling and estimation of relative protein abundance in shotgun proteomics Anal. Chem. 2004, 76 (14) 4193-201
27. MacLean, B.; Tomazela, D. M.; Shulman, N.; Chambers, M.; Finney, G. L.; Frewen, B.; Kern, R.; Tabb, D. L.; Liebler, D. C.; MacCoss, M. J. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments Bioinformatics 2010, 26 (7) 966-8
28. Ashburner, M.; Ball, C. A.; Blake, J. A.; Botstein, D.; Butler, H.; Cherry, J. M.; Davis, A. P.; Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis, A.; Lewis, S.; Matese, J. C.; Richardson, J. E.; Ringwald, M.; Rubin, G. M.; Sherlock, G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat. Genet. 2000, 25 (1) 25-9
29. Gumucio, D. L.; Wiebauer, K.; Caldwell, R. M.; Samuelson, L. C.; Meisler, M. H. Concerted evolution of human amylase genes Mol. Cell. Biol. 1988, 8 (3) 1197-205
30. Whitcomb, D. C.; Lowe, M. E. Human pancreatic digestive enzymes Dig. Dis. Sci. 2007, 52 (1) 1-17
31. Kim, J. T.; Song, E. Y.; Chung, K. S.; Kang, M. A.; Kim, J. W.; Kim, S. J.; Yeom, Y. I.; Kim, J. H.; Kim, K. H.; Lee, H. G. Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer Cancer 2011, 117 (12) 2608-19
32. Miranda, G. M.; Magalhaes, C. A.; Bosco, A. A.; Reis, J. S.; Ribeiro-Oliveira, A., Jr.; Nogueira, A. I.; Leite, R. B.; Miranda, P. A.; Figueiredo, A. F. Increased tissue kallikrein amidase activity in urine of patients with type 1 diabetes under insulin therapy, and in those with gestational diabetes mellitus not under insulin therapy Biochem. Biophys. Res. Commun. 2011, 406 (1) 141-5
33. Tang, S. C.; Leung, J. C.; Lai, K. N. The kallikrein-kinin system Contrib. Nephrol. 2011, 170, 145-55
34. Camilleri, M. Probiotics and irritable bowel syndrome: rationale, putative mechanisms, and evidence of clinical efficacy J. Clin. Gastroenterol. 2006, 40 (3) 264-9
35. Rosenbaum, A. I.; Maxfield, F. R. Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches J. Neurochem. 2011, 116 (5) 789-95
36. Nagata, A.; Suzuki, Y.; Igarashi, M.; Eguchi, N.; Toh, H.; Urade, Y.; Hayaishi, O. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (9) 4020-4
37. Xu, L. F.; Teng, X.; Guo, J.; Sun, M. Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor Inflammation 2012, 35 (1) 308-15
38. Ho, A. S.; Cheng, C. C.; Lee, S. C.; Liu, M. L.; Lee, J. Y.; Wang, W. M.; Wang, C. C. Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI J. Biomed. Sci. 2010, 17, 58
39. Singer, L.; Whitehead, W. T.; Akama, H.; Katz, Y.; Fishelson, Z.; Wetsel, R. A. Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion J. Biol. Chem. 1994, 269 (45) 28494-9
40. Pottiez, G.; Haverland, N.; Ciborowski, P. Mass spectrometric characterization of gelsolin isoforms Rapid Commun. Mass Spectrom. 2010, 24 (17) 2620-4
41. Sotiropoulou, G.; Pampalakis, G.; Diamandis, E. P. Functional roles of human kallikrein-related peptidases J. Biol. Chem. 2009, 284 (48) 32989-94
42. Li, Y.; Zhang, Y.; Qiu, F.; Qiu, Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC Electrophoresis 2011, 32 (15) 1976-83
43. Qi, X.; Loiseau, F.; Chan, W. L.; Yan, Y.; Wei, Z.; Milroy, L. G.; Myers, R. M.; Ley, S. V.; Read, R. J.; Carrell, R. W.; Zhou, A. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins J. Biol. Chem. 2011, 286 (18) 16163-73
44. de Koning, P. J.; Kummer, J. A.; de Poot, S. A.; Quadir, R.; Broekhuizen, R.; McGettrick, A. F.; Higgins, W. J.; Devreese, B.; Worrall, D. M.; Bovenschen, N. Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death PLoS One 2011, 6 (8) e22645
45. Masuda, Y.; Maeda, S.; Watanabe, A.; Sano, Y.; Aiuchi, T.; Nakajo, S.; Itabe, H.; Nakaya, K. A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol Biochem. Biophys. Res. Commun. 2006, 346 (2) 454-60
46. Urbschat, A.; Obermuller, N.; Haferkamp, A. Biomarkers of kidney injury Biomarkers 2011, 16 (Suppl 1) S22-30
47. Matheson, A.; Willcox, M. D.; Flanagan, J.; Walsh, B. J. Urinary biomarkers involved in type 2 diabetes: a review Diabetes/Metab. Res. Rev. 2010, 26 (3) 150-71
48. Sekikawa, A.; Fukui, H.; Suzuki, K.; Karibe, T.; Fujii, S.; Ichikawa, K.; Tomita, S.; Imura, J.; Shiratori, K.; Chiba, T.; Fujimori, T. Involvement of the IL-22/REG Ialpha axis in ulcerative colitis Lab. Invest. 2010, 90 (3) 496-505
49. Yamagishi, H.; Fukui, H.; Sekikawa, A.; Kono, T.; Fujii, S.; Ichikawa, K.; Tomita, S.; Imura, J.; Hiraishi, H.; Chiba, T.; Fujimori, T. Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers Mod. Pathol. 2009, 22 (7) 906-13
50. Nagaraj, N.; Mann, M. Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome J. Proteome Res. 2011, 10 (2) 637-45
51. Panchaud, A.; Jung, S.; Shaffer, S. A.; Aitchison, J. D.; Goodlett, D. R. Faster, quantitative, and accurate precursor acquisition independent from ion count Anal. Chem. 2011, 83 (6) 2250-7
52. Hengel, S. M.; Murray, E.; Langdon, S.; Hayward, L.; O'Donoghue, J.; Panchaud, A.; Hupp, T.; Goodlett, D. R. Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance J. Proteome Res. 2011, 10 (10) 4567-78
53. Diz, A. P.; Truebano, M.; Skibinski, D. O. The consequences of sample pooling in proteomics: an empirical study Electrophoresis 2009, 30 (17) 2967-75
54. Zhang, S. D.; Gant, T. W. Effect of pooling samples on the efficiency of comparative studies using microarrays Bioinformatics 2005, 21 (24) 4378-83
55. Kim, Y. S.; Ho, S. B. Intestinal goblet cells and mucins in health and disease: recent insights and progress Curr. Gastroenterol. Rep. 2010, 12 (5) 319-30
56. Lievin-Le Moal, V.; Servin, A. L. The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota Clin. Microbiol. Rev. 2006, 19 (2) 315-37
57. Camilleri, M.; Madsen, K.; Spiller, R.; Van Meerveld, B. G.; Verne, G. N. Intestinal barrier function in health and gastrointestinal disease Neurogastroenterol. Motil. 2012, 24 (6) 503-12
58. Hoebler, C.; Gaudier, E.; De Coppet, P.; Rival, M.; Cherbut, C. MUC genes are differently expressed during onset and maintenance of inflammation in dextran sodium sulfate-treated mice Dig. Dis. Sci. 2006, 51 (2) 381-9
59. Rinnert, M.; Hinz, M.; Buhtz, P.; Reiher, F.; Lessel, W.; Hoffmann, W. Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine Cell Tissue Res. 2010, 339 (3) 639-47
60. Wallenius, V.; Elias, E.; Bergstrom, G. M.; Zetterberg, H.; Behre, C. J. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men Exp. Clin. Endocrinol. Diabetes 2011, 119 (2) 75-80
61. Hokari, R.; Kurihara, C.; Nagata, N.; Aritake, K.; Okada, Y.; Watanabe, C.; Komoto, S.; Nakamura, M.; Kawaguchi, A.; Nagao, S.; Urade, Y.; Miura, S. Increased expression of lipocalin-type-prostaglandin D synthase in ulcerative colitis and exacerbating role in murine colitis Am. J. Physiol.: Gastrointest. Liver Physiol. 2011, 300 (3) G401-8
62. Lawrance, I. C.; Fiocchi, C.; Chakravarti, S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes Hum. Mol. Genet. 2001, 10 (5) 445-56
63. Manfredi, M. A.; Zurakowski, D.; Rufo, P. A.; Walker, T. R.; Fox, V. L.; Moses, M. A. Increased incidence of urinary matrix metalloproteinases as predictors of disease in pediatric patients with inflammatory bowel disease Inflamm. Bowel Dis. 2008, 14 (8) 1091-6
64. Nielsen, O. H.; Gionchetti, P.; Ainsworth, M.; Vainer, B.; Campieri, M.; Borregaard, N.; Kjeldsen, L. Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis Am. J. Gastroenterol. 1999, 94 (10) 2923-8
65. Li, G. H.; Arora, P. D.; Chen, Y.; McCulloch, C. A.; Liu, P. Multifunctional roles of gelsolin in health and diseases Med. Res. Rev. 2012, 32 (5) 999-1025
66. Haverland, N.; Pottiez, G.; Wiederin, J.; Ciborowski, P. Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation J. Transl. Med. 2010, 8, 137
67. Becker, P. M.; Kazi, A. A.; Wadgaonkar, R.; Pearse, D. B.; Kwiatkowski, D.; Garcia, J. G. Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice Am. J. Respir. Cell Mol. Biol. 2003, 28 (4) 478-84
68. Barbara, G.; Stanghellini, V. Biomarkers in IBS: when will they replace symptoms for diagnosis and management? Gut 2009, 58 (12) 1571-5
69. Rao, A. S.; Camilleri, M.; Eckert, D. J.; Busciglio, I.; Burton, D. D.; Ryks, M.; Wong, B. S.; Lamsam, J.; Singh, R.; Zinsmeister, A. R. Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls Am. J. Physiol.: Gastrointest. Liver Physiol. 2011, 301 (5) G919-28