Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance

Journal of Proteome Research

Volumn 10, Issue 10, 2011, Pages 4567-4578

  Hengel, Shawna Mae ^a,c   Murray, Euan ^b   Langdon, Simon ^b   Hayward, Larry ^b   O'Donoghue, Jean ^b   Panchaud, Alexandre ^a   Hupp, Ted ^b   Goodlett, David R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

AGR2; anterior gradient 2 homologue; data independent; PAcIFIC; tamoxifen

Indexed keywords

ANTERIOR GRADIENT 2; PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CELL STRAIN MCF 7; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FRACTIONATION; HUMAN; HUMAN CELL; PRECURSOR ACQUISITION INDEPENDENT FROM ION COUNT; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE ANALYSIS; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; MODELS, CHEMICAL; NEOPLASM TRANSPLANTATION; PROTEINS; PROTEOMICS; TAMOXIFEN;

EID: 80053909031     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr2004117     Document Type: Article

References (47)

1. Mardis, E. R.; Ding, L.; Dooling, D. J.; Larson, D. E.; McLellan, M. D.; Chen, K.; Koboldt, D. C.; Fulton, R. S.; Delehaunty, K. D.; McGrath, S. D.; Fulton, L. A.; Locke, D. P.; Magrini, V. J.; Abbott, R. M.; Vickery, T. L.; Reed, J. S.; Robinson, J. S.; Wylie, T.; Smith, S. M.; Carmichael, L.; Eldred, J. M.; Harris, C. C.; Walker, J.; Peck, J. B.; Du, F.; Dukes, A. F.; Sanderson, G. E.; Brummett, A. M.; Clark, E.; McMichael, J. F.; Meyer, R. J.; Schindler, J. K.; Pohl, C. S.; Wallis, J. W.; Shi, X.; Lin, L.; Schmidt, H.; Tang, Y.; Haipek, C.; Wiechert, M. E.; Ivy, J. V.; Kalicki, J.; Elliott, G.; Ries, R. E.; Payton, J. E.; Westervelt, P.; Tomasson, M. H.; Watson, M. A.; Baty, J.; Heath, S.; Shannon, W. D.; Nagarajan, R.; Link, D. C.; Walter, M. J.; Graubert, T. A.; DiPersio, J. F.; Wilson, R. K.; Ley, T. J. Recurring mutations found by sequencing an acute myeloid leukemia genome N. Engl. J. Med. 2009, 361 (11) 1058-66
2. Mardis, E. R.; Wilson, R. K. Cancer genome sequencing: a review Hum. Mol. Genet. 2009, 18 (R2) R163-8
3. Pleasance, E. D.; Cheetham, R. K.; Stephens, P. J.; McBride, D. J.; Humphray, S. J.; Greenman, C. D.; Varela, I.; Lin, M. L.; Ordonez, G. R.; Bignell, G. R.; Ye, K.; Alipaz, J.; Bauer, M. J.; Beare, D.; Butler, A.; Carter, R. J.; Chen, L.; Cox, A. J.; Edkins, S.; Kokko-Gonzales, P. I.; Gormley, N. A.; Grocock, R. J.; Haudenschild, C. D.; Hims, M. M.; James, T.; Jia, M.; Kingsbury, Z.; Leroy, C.; Marshall, J.; Menzies, A.; Mudie, L. J.; Ning, Z.; Royce, T.; Schulz-Trieglaff, O. B.; Spiridou, A.; Stebbings, L. A.; Szajkowski, L.; Teague, J.; Williamson, D.; Chin, L.; Ross, M. T.; Campbell, P. J.; Bentley, D. R.; Futreal, P. A.; Stratton, M. R. A comprehensive catalogue of somatic mutations from a human cancer genome Nature 2011, 463 (7278) 191-6
4. Stratton, M. R.; Campbell, P. J.; Futreal, P. A. The cancer genome Nature 2009, 458 (7239) 719-24
5. Nie, L.; Wu, G.; Zhang, W. Correlation between mRNA and protein abundance in Desulfovibrio vulgaris: a multiple regression to identify sources of variations Biochem. Biophys. Res. Commun. 2006, 339 (2) 603-10 (Pubitemid 41739710)
6. Chen, G.; Gharib, T. G.; Huang, C. C.; Taylor, J. M.; Misek, D. E.; Kardia, S. L.; Giordano, T. J.; Iannettoni, M. D.; Orringer, M. B.; Hanash, S. M.; Beer, D. G. Discordant protein and mRNA expression in lung adenocarcinomas Mol. Cell. Proteomics 2002, 1 (4) 304-13
7. Washburn, M. P.; Wolters, D.; Yates, J. R., 3rd Large-scale analysis of the yeast proteome by multidimensional protein identification technology Nat. Biotechnol. 2001, 19 (3) 242-7 (Pubitemid 32220565)
8. Neville, D. C.; Rozanas, C. R.; Price, E. M.; Gruis, D. B.; Verkman, A. S.; Townsend, R. R. Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry Protein Sci. 1997, 6 (11) 2436-45 (Pubitemid 27490754)
9. Scherl, A.; Shaffer, S. A.; Taylor, G. K.; Kulasekara, H. D.; Miller, S. I.; Goodlett, D. R. Genome-specific gas-phase fractionation strategy for improved shotgun proteomic profiling of proteotypic peptides Anal. Chem. 2008, 80 (4) 1182-91 (Pubitemid 351272354)
10. Ong, S. E.; Blagoev, B.; Kratchmarova, I.; Kristensen, D. B.; Steen, H.; Pandey, A.; Mann, M. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics Mol. Cell. Proteomics 2002, 1 (5) 376-86
11. Choe, L. H.; Aggarwal, K.; Franck, Z.; Lee, K. H. A comparison of the consistency of proteome quantitation using two-dimensional electrophoresis and shotgun isobaric tagging in Escherichia coli cells Electrophoresis 2005, 26 (12) 2437-49 (Pubitemid 40932751)
12. Ross, P. L.; Huang, Y. N.; Marchese, J. N.; Williamson, B.; Parker, K.; Hattan, S.; Khainovski, N.; Pillai, S.; Dey, S.; Daniels, S.; Purkayastha, S.; Juhasz, P.; Martin, S.; Bartlet-Jones, M.; He, F.; Jacobson, A.; Pappin, D. J. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents Mol. Cell. Proteomics 2004, 3 (12) 1154-69
13. Thompson, A.; Schafer, J.; Kuhn, K.; Kienle, S.; Schwarz, J.; Schmidt, G.; Neumann, T.; Johnstone, R.; Mohammed, A. K.; Hamon, C. Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS Anal. Chem. 2003, 75 (8) 1895-904 (Pubitemid 36438013)
14. Panchaud, A.; Scherl, A.; Shaffer, S. A.; von Haller, P. D.; Kulasekara, H. D.; Miller, S. I.; Goodlett, D. R. Precursor acquisition independent from ion count: how to dive deeper into the proteomics ocean Anal. Chem. 2009, 81 (15) 6481-8
15. Veronesi, U.; Boyle, P.; Goldhirsch, A.; Orecchia, R.; Viale, G. Breast cancer Lancet 2005, 365 (9472) 1727-41 (Pubitemid 40719108)
16. Hinestrosa, M. C.; Dickersin, K.; Klein, P.; Mayer, M.; Noss, K.; Slamon, D.; Sledge, G.; Visco, F. M. Shaping the future of biomarker research in breast cancer to ensure clinical relevance Nat. Rev. Cancer 2007, 7 (4) 309-15 (Pubitemid 46480973)
17. Clarke, R.; Liu, M. C.; Bouker, K. B.; Gu, Z.; Lee, R. Y.; Zhu, Y.; Skaar, T. C.; Gomez, B.; O'Brien, K.; Wang, Y.; Hilakivi-Clarke, L. A. Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling Oncogene 2003, 22 (47) 7316-39 (Pubitemid 37492898)
18. Massarweh, S.; Schiff, R. Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk Endocr. Relat. Cancer 2006, 13 (Suppl 1) S15-24
19. Cory, A. H.; Owen, T. C.; Barltrop, J. A.; Cory, J. G. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture Cancer Commun. 1991, 3 (7) 207-12
20. Pohler, E.; Craig, A. L.; Cotton, J.; Lawrie, L.; Dillon, J. F.; Ross, P.; Kernohan, N.; Hupp, T. R. The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage Mol. Cell. Proteomics 2004, 3 (6) 534-47 (Pubitemid 38878513)
21. Sewell, J. M.; Macleod, K. G.; Ritchie, A.; Smyth, J. F.; Langdon, S. P. Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 ("Iressa") Br. J. Cancer 2002, 86 (3) 456-62 (Pubitemid 34185133)
22. Macleod, K.; Mullen, P.; Sewell, J.; Rabiasz, G.; Lawrie, S.; Miller, E.; Smyth, J. F.; Langdon, S. P. Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer Cancer Res. 2005, 65 (15) 6789-800 (Pubitemid 41060717)
23. Workman, P.; Aboagye, E. O.; Balkwill, F.; Balmain, A.; Bruder, G.; Chaplin, D. J.; Double, J. A.; Everitt, J.; Farningham, D. A.; Glennie, M. J.; Kelland, L. R.; Robinson, V.; Stratford, I. J.; Tozer, G. M.; Watson, S.; Wedge, S. R.; Eccles, S. A. Guidelines for the welfare and use of animals in cancer research Br. J. Cancer 2010, 102 (11) 1555-77
24. Yi, E. C.; Lee, H.; Aebersold, R.; Goodlett, D. R. A microcapillary trap cartridge-microcapillary high-performance liquid chromatography electrospray ionization emitter device capable of peptide tandem mass spectrometry at the attomole level on an ion trap mass spectrometer with automated routine operation Rapid Commun. Mass Spectrom. 2003, 17 (18) 2093-8 (Pubitemid 37093085)
25. Eng, J. K.; Mccormack, A. L.; Yates, J. R. An Approach to Correlate Tandem Mass-Spectral Data of Peptides with Amino-Acid-Sequences in a Protein Database J. Am. Soc. Mass Spectrom. 1994, 5 (11) 976-89
26. Nesvizhskii, A. I.; Keller, A.; Kolker, E.; Aebersold, R. A statistical model for identifying proteins by tandem mass spectrometry Anal. Chem. 2003, 75 (17) 4646-58 (Pubitemid 37082259)
27. Ryu, S.; Gallis, B.; Goo, Y. A.; Shaffer, S. A.; Radulovic, D.; Goodlett, D. R. Comparison of a label-free quantitative proteomic method based on Peptide ion current area to the isotope coded affinity tag method Cancer Inform. 2008, 6, 243-55
28. Ramachandran, V.; Arumugam, T.; Wang, H.; Logsdon, C. D. Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival Cancer Res. 2008, 68 (19) 7811-8
29. Innes, H. E.; Liu, D.; Barraclough, R.; Davies, M. P.; O'Neill, P. A.; Platt-Higgins, A.; de Silva Rudland, S.; Sibson, D. R.; Rudland, P. S. Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients Br. J. Cancer 2006, 94 (7) 1057-65
30. Kumar, A.; Godwin, J. W.; Gates, P. B.; Garza-Garcia, A. A.; Brockes, J. P. Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate Science 2007, 318 (5851) 772-7 (Pubitemid 351411765)
31. Wang, Z.; Hao, Y.; Lowe, A. W. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation Cancer Res. 2008, 68 (2) 492-7 (Pubitemid 351380076)
32. Barraclough, D. L.; Platt-Higgins, A.; de Silva Rudland, S.; Barraclough, R.; Winstanley, J.; West, C. R.; Rudland, P. S. The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients. Am. J. Pathol. 2009, not supplied.
33. Neubauer, H.; Clare, S. E.; Kurek, R.; Fehm, T.; Wallwiener, D.; Sotlar, K.; Nordheim, A.; Wozny, W.; Schwall, G. P.; Poznanovic, S.; Sastri, C.; Hunzinger, C.; Stegmann, W.; Schrattenholz, A.; Cahill, M. A. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection Electrophoresis 2006, 27 (9) 1840-52
34. Wang, Y.; He, Q. Y.; Chen, H.; Chiu, J. F. Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization Exp. Cell Res. 2007, 313 (2) 357-68 (Pubitemid 46048821)
35. Umar, A.; Kang, H.; Timmermans, A. M.; Look, M. P.; Meijer-van Gelder, M. E.; den Bakker, M. A.; Jaitly, N.; Martens, J. W.; Luider, T. M.; Foekens, J. A.; Pasa-Tolic, L. Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer Mol. Cell. Proteomics 2009, 8 (6) 1278-94
36. Panchaud, A.; Jung, S.; Shaffer, S. A.; Aitchison, J. D.; Goodlett, D. R. Faster, quantitative, and accurate precursor acquisition independent from ion count Anal. Chem. 2011, 83 (6) 2250-7
37. Yi, E. C.; Marelli, M.; Lee, H.; Purvine, S. O.; Aebersold, R.; Aitchison, J. D.; Goodlett, D. R. Approaching complete peroxisome characterization by gas-phase fractionation Electrophoresis 2002, 23 (18) 3205-16 (Pubitemid 35154170)
38. Zhang, Y.; Forootan, S. S.; Liu, D.; Barraclough, R.; Foster, C. S.; Rudland, P. S.; Ke, Y. Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients Prostate Cancer Prostatic Dis. 2007, 10 (3) 293-300 (Pubitemid 47351409)
39. Moore, H. E.; Davenport, E. L.; Smith, E. M.; Muralikrishnan, S.; Dunlop, A. S.; Walker, B. A.; Krige, D.; Drummond, A. H.; Hooftman, L.; Morgan, G. J.; Davies, F. E. Aminopeptidase inhibition as a targeted treatment strategy in myeloma Mol. Cancer Ther. 2009, 8 (4) 762-70
40. Redondo, M.; Tellez, T.; Roldan, M. J.; Serrano, A.; Garcia-Aranda, M.; Gleave, M. E.; Hortas, M. L.; Morell, M. Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity Breast Cancer Res. 2007, 9 (6) R86
41. Toffanin, S.; Daidone, M. G.; Miodini, P.; De Cecco, L.; Gandellini, P.; Cappelletti, V. Clusterin: a potential target for improving response to antiestrogens Int. J. Oncol. 2008, 33 (4) 791-8
42. Gonzalez, M. E.; Peterson, E. A.; Privette, L. M.; Loffreda-Wren, J. L.; Kalikin, L. M.; Petty, E. M. High SEPT9-v1 expression in human breast cancer cells is associated with oncogenic phenotypes Cancer Res. 2007, 67 (18) 8554-64
43. Shaffer, S. A.; Prior, D. C.; Anderson, G. A.; Udseth, H. R.; Smith, R. D. An ion funnel interface for improved ion focusing and sensitivity using electrospray ionization mass spectrometry Anal. Chem. 1998, 70 (19) 4111-9 (Pubitemid 128484755)
44. Shaffer, S. A.; Tolmachev, A.; Prior, D. C.; Anderson, G. A.; Udseth, H. R.; Smith, R. D. Characterization of an improved electrodynamic ion funnel interface for electrospray ionization mass spectrometry Anal. Chem. 1999, 71 (15) 2957-64 (Pubitemid 29372706)
45. Olsen, J. V.; Schwartz, J. C.; Griep-Raming, J.; Nielsen, M. L.; Damoc, E.; Denisov, E.; Lange, O.; Remes, P.; Taylor, D.; Splendore, M.; Wouters, E. R.; Senko, M.; Makarov, A.; Mann, M.; Horning, S. A dual pressure linear ion trap orbitrap instrument with very high sequencing speed Mol. Cell. Proteomics 2009, 8 (12) 2759-69
46. Second, T. P.; Blethrow, J. D.; Schwartz, J. C.; Merrihew, G. E.; MacCoss, M. J.; Swaney, D. L.; Russell, J. D.; Coon, J. J.; Zabrouskov, V. Dual-pressure linear ion trap mass spectrometer improving the analysis of complex protein mixtures Anal. Chem. 2009, 81 (18) 7757-65
47. Picotti, P.; Rinner, O.; Stallmach, R.; Dautel, F.; Farrah, T.; Domon, B.; Wenschuh, H.; Aebersold, R. High-throughput generation of selected reaction-monitoring assays for proteins and proteomes Nat. Methods 2010, 7 (1) 43-6