메뉴 건너뛰기




Volumn 8, Issue 12, 2012, Pages 1811-1821

Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- And RIPK1/RIP1-mediated MAPK8/JNK activation

Author keywords

Apoptosis; Autophagy; MAPK8 JNK; RIPK1 RIP1; TNFSF10 TRAIL; TRAF2

Indexed keywords

BECLIN 1; CARRIER PROTEIN; CELL PROTEIN; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN ATG7; PROTEIN BCL XL; PROTEIN RIPK1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84870909002     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.22145     Document Type: Article
Times cited : (120)

References (40)
  • 1
    • 77957045066 scopus 로고    scopus 로고
    • TRAIL receptor signaling and therapeutics
    • PMID:20819019
    • Abdulghani J, El-Deiry WS. TRAIL receptor signaling and therapeutics. Expert Opin Ther Targets 2010; 14:1091-108; PMID:20819019; http://dx.doi.org/10. 1517/14728222.2010.519701
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 1091-1108
    • Abdulghani, J.1    El-Deiry, W.S.2
  • 2
    • 77950862659 scopus 로고    scopus 로고
    • TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives
    • PMID:20036602
    • Stegehuis JH, de Wilt LH, de Vries EG, Groen HJ, de Jong S, Kruyt FA. TRAIL receptor targeting therapies for non-small cell lung cancer: current status and perspectives. Drug Resist Updat 2010; 13:2-15; PMID:20036602; http://dx.doi.org/10.1016/j.drup.2009.11.001
    • (2010) Drug Resist Updat , vol.13 , pp. 2-15
    • Stegehuis, J.H.1    De Wilt, L.H.2    De Vries, E.G.3    Groen, H.J.4    De Jong, S.5    Kruyt, F.A.6
  • 3
    • 70349318434 scopus 로고    scopus 로고
    • Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a phase I and pharmacokinetic study
    • PMID:19652058
    • Leong S, Cohen RB, Gustafson DL, Langer CJ, Camidge DR, Padavic K, et al. Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J Clin Oncol 2009; 27:4413-21; PMID:19652058; http://dx.doi.org/10.1200/JCO.2008.21.7422
    • (2009) J Clin Oncol , vol.27 , pp. 4413-4421
    • Leong, S.1    Cohen, R.B.2    Gustafson, D.L.3    Langer, C.J.4    Camidge, D.R.5    Padavic, K.6
  • 4
    • 84855643244 scopus 로고    scopus 로고
    • TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies
    • PMID:22234808
    • Hellwig CT, Rehm M. TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies. Mol Cancer Ther 2012; 11:3-13; PMID:22234808; http://dx.doi.org/10.1158/1535-7163.MCT-11-0434
    • (2012) Mol Cancer Ther , vol.11 , pp. 3-13
    • Hellwig, C.T.1    Rehm, M.2
  • 5
    • 33645467484 scopus 로고    scopus 로고
    • Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3
    • PMID:16546965
    • Lane D, Côté M, Grondin R, Couture MC, PichéA. Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3. Mol Cancer Ther 2006; 5:509-21; PMID:16546965; http://dx.doi.org/10.1158/1535-7163.MCT-05-0362
    • (2006) Mol Cancer Ther , vol.5 , pp. 509-521
    • Lane, D.1    Côté, M.2    Grondin, R.3    Couture, M.C.4    Piché, A.5
  • 6
    • 33846969909 scopus 로고    scopus 로고
    • Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL
    • PMID:17110373
    • Song JJ, An JY, Kwon YT, Lee YJ. Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. J Biol Chem 2007; 282:319-28; PMID:17110373; http://dx.doi.org/10.1074/jbc.M608065200
    • (2007) J Biol Chem , vol.282 , pp. 319-328
    • Song, J.J.1    An, J.Y.2    Kwon, Y.T.3    Lee, Y.J.4
  • 7
    • 33748706160 scopus 로고    scopus 로고
    • Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors
    • PMID:16470224
    • Wenger T, Mattern J, Penzel R, Gassler N, Haas TL, Sprick MR, et al. Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors. Cell Death Differ 2006; 13:1740-51; PMID:16470224; http://dx.doi.org/10.1038/sj.cdd.4401867
    • (2006) Cell Death Differ , vol.13 , pp. 1740-1751
    • Wenger, T.1    Mattern, J.2    Penzel, R.3    Gassler, N.4    Haas, T.L.5    Sprick, M.R.6
  • 8
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • PMID:11711427
    • Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15:2922-33; PMID:11711427.
    • (2001) Genes Dev , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 9
    • 0033821215 scopus 로고    scopus 로고
    • The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase
    • PMID:10958661
    • Lin Y, Devin A, Cook A, Keane MM, Kelliher M, Lipkowitz S, et al. The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase. Mol Cell Biol 2000; 20:6638-45; PMID:10958661; http://dx.doi.org/10.1128/MCB.20.18.6638-6645.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 6638-6645
    • Lin, Y.1    Devin, A.2    Cook, A.3    Keane, M.M.4    Kelliher, M.5    Lipkowitz, S.6
  • 10
    • 3042704181 scopus 로고    scopus 로고
    • TRAIL and NFkappaB signaling - A complex relationship
    • PMID:15110174
    • Wajant H. TRAIL and NFkappaB signaling - a complex relationship. Vitam Horm 2004; 67:101-32; PMID:15110174; http://dx.doi.org/10.1016/S0083-6729(04) 67007-5
    • (2004) Vitam Horm , vol.67 , pp. 101-132
    • Wajant, H.1
  • 11
    • 14044278635 scopus 로고    scopus 로고
    • Tumor therapeutics by design: Targeting and activation of death receptors
    • PMID:15733832
    • Wajant H, Gerspach J, Pfizenmaier K. Tumor therapeutics by design: targeting and activation of death receptors. Cytokine Growth Factor Rev 2005; 16:55-76; PMID:15733832; http://dx.doi.org/10.1016/j.cytogfr.2004.12.001
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 55-76
    • Wajant, H.1    Gerspach, J.2    Pfizenmaier, K.3
  • 12
    • 49849097056 scopus 로고    scopus 로고
    • Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells
    • PMID:18483303
    • Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, et al. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol Cancer Ther 2008; 7:1156-63; PMID:18483303; http://dx.doi.org/10.1158/1535-7163.MCT-07-2183
    • (2008) Mol Cancer Ther , vol.7 , pp. 1156-1163
    • Wang, X.1    Chen, W.2    Zeng, W.3    Bai, L.4    Tesfaigzi, Y.5    Belinsky, S.A.6
  • 13
    • 77149128046 scopus 로고    scopus 로고
    • Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis
    • PMID:19933775
    • Chen W, Bai L, Wang X, Xu S, Belinsky SA, Lin Y. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol Pharmacol 2010; 77:416-23; PMID:19933775; http://dx.doi.org/10. 1124/mol.109.061226
    • (2010) Mol Pharmacol , vol.77 , pp. 416-423
    • Chen, W.1    Bai, L.2    Wang, X.3    Xu, S.4    Belinsky, S.A.5    Lin, Y.6
  • 14
    • 79958764460 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells
    • PMID:21525012
    • Li Z, Xu X, Bai L, Chen W, Lin Y. Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells. J Biol Chem 2011; 286:21164-72; PMID:21525012; http://dx.doi.org/10.1074/jbc.M110.207571
    • (2011) J Biol Chem , vol.286 , pp. 21164-21172
    • Li, Z.1    Xu, X.2    Bai, L.3    Chen, W.4    Lin, Y.5
  • 15
    • 57849136841 scopus 로고    scopus 로고
    • Autophagy: Principles and significance in health and disease
    • PMID:19022377
    • Todde V, Veenhuis M, van der Klei IJ. Autophagy: principles and significance in health and disease. Biochim Biophys Acta 2009; 1792:3-13; PMID:19022377; http://dx.doi.org/10.1016/j.bbadis.2008.10.016
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 3-13
    • Todde, V.1    Veenhuis, M.2    Van Der Klei, I.J.3
  • 16
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • PMID:22078875
    • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728-41; PMID:22078875; http://dx.doi.org/10.1016/j.cell.2011.10.026
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 17
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • PMID:16179260
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39; PMID:16179260; http://dx.doi.org/10.1016/j.cell.2005.07.002
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 18
    • 79960917666 scopus 로고    scopus 로고
    • Autophagy as a mediator of chemotherapy-induced cell death in cancer
    • PMID:21704023
    • Notte A, Leclere L, Michiels C. Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol 2011; 82:427-34; PMID:21704023; http://dx.doi.org/10.1016/j.bcp.2011.06.015
    • (2011) Biochem Pharmacol , vol.82 , pp. 427-434
    • Notte, A.1    Leclere, L.2    Michiels, C.3
  • 19
    • 77951171023 scopus 로고    scopus 로고
    • Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
    • PMID:20200450
    • Bonapace L, Bornhauser BC, Schmitz M, Cario G, Ziegler U, Niggli FK, et al. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest 2010; 120:1310-23; PMID:20200450; http://dx.doi.org/10.1172/JCI39987
    • (2010) J Clin Invest , vol.120 , pp. 1310-1323
    • Bonapace, L.1    Bornhauser, B.C.2    Schmitz, M.3    Cario, G.4    Ziegler, U.5    Niggli, F.K.6
  • 20
    • 84857366779 scopus 로고    scopus 로고
    • The autophagic paradox in cancer therapy
    • PMID:21765470
    • Wu WK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FK, et al. The autophagic paradox in cancer therapy. Oncogene 2012; 31:939-53; PMID:21765470; http://dx.doi.org/10.1038/onc.2011.295
    • (2012) Oncogene , vol.31 , pp. 939-953
    • Wu, W.K.1    Coffelt, S.B.2    Cho, C.H.3    Wang, X.J.4    Lee, C.W.5    Chan, F.K.6
  • 21
    • 1542513774 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    • PMID:14993595
    • Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A 2004; 101:3438-43; PMID:14993595; http://dx.doi.org/10.1073/pnas.0400443101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3438-3443
    • Mills, K.R.1    Reginato, M.2    Debnath, J.3    Queenan, B.4    Brugge, J.S.5
  • 22
    • 50349098812 scopus 로고    scopus 로고
    • Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
    • PMID:18375389
    • Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, et al. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 2008; 283:19665-77; PMID:18375389; http://dx.doi.org/10.1074/jbc. M710169200
    • (2008) J Biol Chem , vol.283 , pp. 19665-19677
    • Han, J.1    Hou, W.2    Goldstein, L.A.3    Lu, C.4    Stolz, D.B.5    Yin, X.M.6
  • 23
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • PMID:20144757
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140:313-26; PMID:20144757; http://dx.doi.org/10.1016/j. cell.2010.01.028
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 24
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • PMID:18188003
    • Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151-75; PMID:18188003
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3    Agrawal, D.K.4    Aliev, G.5    Askew, D.S.6
  • 25
    • 77957654940 scopus 로고    scopus 로고
    • Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis
    • PMID:20724831
    • Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy 2010; 6:891-900; PMID:20724831; http://dx.doi.org/10.4161/auto.6.7. 13038
    • (2010) Autophagy , vol.6 , pp. 891-900
    • Hou, W.1    Han, J.2    Lu, C.3    Goldstein, L.A.4    Rabinowich, H.5
  • 26
    • 53549092494 scopus 로고    scopus 로고
    • Enhancement of tumor-TRAIL susceptibility by modulation of autophagy
    • PMID:18769107
    • Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Enhancement of tumor-TRAIL susceptibility by modulation of autophagy. Autophagy 2008; 4:940-3; PMID:18769107
    • (2008) Autophagy , vol.4 , pp. 940-943
    • Hou, W.1    Han, J.2    Lu, C.3    Goldstein, L.A.4    Rabinowich, H.5
  • 27
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • PMID:18570871
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30:678-88; PMID:18570871; http://dx.doi.org/10.1016/j.molcel.2008.06.001
    • (2008) Mol Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 29
    • 78751655392 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis
    • PMID:21182587
    • Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 2011; 278:403-13; PMID:21182587; http://dx.doi.org/10.1111/j.1742-4658.2010.07965.x
    • (2011) FEBS J , vol.278 , pp. 403-413
    • Zhou, F.1    Yang, Y.2    Xing, D.3
  • 30
    • 80051525732 scopus 로고    scopus 로고
    • Oxaliplatin uses JNK to restore TRAIL sensitivity in cancer cells through Bcl-xL inactivation
    • PMID:21699898
    • Allen JE, El-Deiry WS. Oxaliplatin uses JNK to restore TRAIL sensitivity in cancer cells through Bcl-xL inactivation. Gastroenterology 2011; 141:430-4; PMID:21699898; http://dx.doi.org/10.1053/j.gastro.2011.06.026
    • (2011) Gastroenterology , vol.141 , pp. 430-434
    • Allen, J.E.1    El-Deiry, W.S.2
  • 31
    • 77950487987 scopus 로고    scopus 로고
    • Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
    • PMID:20040365
    • Korolchuk VI, Menzies FM, Rubinsztein DC. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett 2010; 584:1393-8; PMID:20040365; http://dx.doi.org/10.1016/j.febslet.2009.12.047
    • (2010) FEBS Lett , vol.584 , pp. 1393-1398
    • Korolchuk, V.I.1    Menzies, F.M.2    Rubinsztein, D.C.3
  • 32
    • 60549093730 scopus 로고    scopus 로고
    • Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
    • PMID:19250912
    • Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 2009; 33:517-27; PMID:19250912; http://dx.doi.org/10.1016/j.molcel. 2009.01.021
    • (2009) Mol Cell , vol.33 , pp. 517-527
    • Korolchuk, V.I.1    Mansilla, A.2    Menzies, F.M.3    Rubinsztein, D.C.4
  • 33
    • 0042734434 scopus 로고    scopus 로고
    • The true face of JNK activation in apoptosis
    • PMID:12882340
    • Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell 2002; 1:112-6; PMID:12882340; http://dx.doi.org/10.1046/j.1474-9728.2002. 00014.x
    • (2002) Aging Cell , vol.1 , pp. 112-116
    • Lin, A.1    Dibling, B.2
  • 34
    • 10044265209 scopus 로고    scopus 로고
    • JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
    • PMID:15545623
    • Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr., Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 2004; 18:2905-15; PMID:15545623; http://dx.doi.org/10.1101/gad.1223004
    • (2004) Genes Dev , vol.18 , pp. 2905-2915
    • Ventura, J.J.1    Cogswell, P.2    Flavell, R.A.3    Baldwin Jr., A.S.4    Davis, R.J.5
  • 35
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • PMID:14967141
    • Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004; 13:329-40; PMID:14967141; http://dx.doi.org/10.1016/S1097-2765(04) 00028-0
    • (2004) Mol Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3    Liu, J.4    Tang, F.5    Bui, T.N.6
  • 36
    • 65549105835 scopus 로고    scopus 로고
    • Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines
    • PMID:19352384
    • Mahalingam D, Keane M, Pirianov G, Mehmet H, Samali A, Szegezdi E. Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. Br J Cancer 2009; 100:1415-24; PMID:19352384; http://dx.doi.org/10.1038/sj.bjc.6605021
    • (2009) Br J Cancer , vol.100 , pp. 1415-1424
    • Mahalingam, D.1    Keane, M.2    Pirianov, G.3    Mehmet, H.4    Samali, A.5    Szegezdi, E.6
  • 37
    • 79951720176 scopus 로고    scopus 로고
    • JNK regulates FoxO-dependent autophagy in neurons
    • PMID:21325132
    • Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 2011; 25:310-22; PMID:21325132; http://dx.doi.org/10.1101/ gad.1984311
    • (2011) Genes Dev , vol.25 , pp. 310-322
    • Xu, P.1    Das, M.2    Reilly, J.3    Davis, R.J.4
  • 38
    • 31544470589 scopus 로고    scopus 로고
    • 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway
    • PMID:16424045
    • Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 2006; 66:1089-95; PMID:16424045; http://dx.doi.org/10.1158/0008-5472.CAN-05-2698
    • (2006) Cancer Res , vol.66 , pp. 1089-1095
    • Wang, X.1    Ju, W.2    Renouard, J.3    Aden, J.4    Belinsky, S.A.5    Lin, Y.6
  • 39
    • 67649371458 scopus 로고    scopus 로고
    • IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells
    • PMID:19509265
    • Bai L, Chen W, Chen W, Wang X, Tang H, Lin Y. IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells. Mol Cancer Ther 2009; 8:1636-45; PMID:19509265; http://dx.doi.org/10. 1158/1535-7163.MCT-09-0068
    • (2009) Mol Cancer Ther , vol.8 , pp. 1636-1645
    • Bai, L.1    Chen, W.2    Chen, W.3    Wang, X.4    Tang, H.5    Lin, Y.6
  • 40
    • 0033725155 scopus 로고    scopus 로고
    • The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
    • PMID:10795740
    • Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 2000; 12:419-29; PMID:10795740; http://dx.doi.org/10.1016/S1074-7613(00)80194-6
    • (2000) Immunity , vol.12 , pp. 419-429
    • Devin, A.1    Cook, A.2    Lin, Y.3    Rodriguez, Y.4    Kelliher, M.5    Liu, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.