Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations

Drug and Alcohol Dependence

Volumn 127, Issue 1-3, 2013, Pages 122-128

  Crist, R C ^a   Ambrose Lanci, L M ^a   Vaswani, M ^a,b   Clarke, T K ^a   Zeng, A ^a   Yuan, C ^a   Ferraro, T N ^a   Hakonarson, H ^d,e   Kampman, K M ^a   Dackis, C A ^a   Pettinati, H M ^a   O'Brien, C P ^a   Oslin, D W ^a,c   Doyle, G A ^a   Lohoff, F W ^a   Berrettini, W H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Addiction; Association study; Delta opioid receptor; Genetics; OPRD1

Indexed keywords

COCAINE; DELTA OPIATE RECEPTOR; OPIATE;

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; CASE CONTROL STUDY; COCAINE DEPENDENCE; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; GENE; GENE FUNCTION; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPIATE ADDICTION; OPRD1 GENE; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; CASE-CONTROL STUDIES; COCAINE-RELATED DISORDERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MALE; OPIOID-RELATED DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION SURVEILLANCE; RECEPTORS, OPIOID, DELTA;

EID: 84870907206     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2012.06.023     Document Type: Article

References (52)

1. Ambrose-Lanci L.M. Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment. J. Neurosci. Res. 2009, 88:816-824.
2. Arvidsson U., Riedl M., Chakrabarti S., Lee J.H., Nakano A.H., Dado R.J., Loh H.H., Law P.Y., Wessendorf M.W., Elde R. Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 1995, 15:3328-3341.
3. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
4. Bart G., Heilig M., LaForge K.S., Pollak L., Leal S.M., Ott J., Kreek M.J. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol. Psychiatry 2004, 9:547-549.
5. Becker A., Grecksch G., Kraus J., Loh H.H., Schroeder H., Hollt V. Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn Schmiedebergs Arch. Pharmacol. 2002, 365:296-302.
6. Benjamini Y., Drai D., Elmer G., Kafkafi N., Golani I. Controlling the false discovery rate in behavior genetics research. Behav. Brain Res. 2001, 125:279-284.
7. Childers S.R. Opioid receptor-coupled second messenger systems. Life Sci. 1991, 48:1991-2003.
8. Crowley J.J., Oslin D.W., Patkar A.A., Gottheil E., DeMaria P.A., O'Brien C.P., Berrettini W.H., Grice D.E. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr. Genet. 2003, 13:169-173.
9. Di Chiara G., Imperato A. Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J. Pharmacol. Exp. Ther. 1988, 244:1067-1080.
10. Ducci F., Roy A., Shen P.H., Yuan Q., Yuan N.P., Hodgkinson C.A., Goldman L.R., Goldman D. Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am. J. Psychiatry 2009, 166:1031-1040.
11. Filliol D., Ghozland S., Chluba J., Martin M., Matthes H.W., Simonin F., Befort K., Gaveriaux-Ruff C., Dierich A., LeMeur M., Valverde O., Maldonado R., Kieffer B.L. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat. Genet. 2000, 25:195-200.
12. Franke P., Nothen M.M., Wang T., Neidt H., Knapp M., Lichtermann D., Weiffenbach O., Mayer P., Hollt V., Propping P., Maier W. Human delta-opioid receptor gene and susceptibility to heroin and alcohol dependence. Am. J. Med. Genet. 1999, 88:462-464.
13. Gelernter J., Gueorguieva R., Kranzler H.R., Zhang H., Cramer J., Rosenheck R., Krystal J.H. Opioid receptor gene (OPRM1 OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol. Clin. Exp. Res. 2007, 31:555-563.
14. Hall F.S., Goeb M., Li X.F., Sora I., Uhl G.R. mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion. Brain Res. 2004, 121:123-130.
15. Herz A. Opioid reward mechanisms: a key role in drug abuse?. Can. J. Physiol. Pharmacol. 1998, 76:252-258.
16. Hoehe M.R., Kopke K., Wendel B., Rohde K., Flachmeier C., Kidd K.K., Berrettini W.H., Church G.M. Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum. Mol. Genet. 2000, 9:2895-2908.
17. Hummel M., Schroeder J., Liu-Chen L.Y., Cowan A., Unterwald E.M. An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience 2006, 142:481-491.
18. Jutkiewicz E.M. The antidepressant-like effects of delta-opioid receptor agonists. Mol. Interv. 2006, 6:162-169.
19. Karkowski L.M., Prescott C.A., Kendler K.S. Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. Am. J. Med. Genet. 2000, 96:665-670.
20. Kendler K.S., Jacobson K.C., Prescott C.A., Neale M.C. Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am. J. Psychiatry 2003, 160:687-695.
21. Kendler K.S., Karkowski L.M., Neale M.C., Prescott C.A. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch. Gen. Psychiatry 2000, 57:261-269.
22. Kendler K.S., Prescott C.A. Cocaine use, abuse and dependence in a population-based sample of female twins. Br. J. Psychiatry 1998, 173:345-350.
23. Konig M., Zimmer A.M., Steiner H., Holmes P.V., Crawley J.N., Brownstein M.J., Zimmer A. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 1996, 383:535-538.
24. Kreek M.J., Bart G., Lilly C., LaForge K.S., Nielsen D.A. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 2005, 57:1-26.
25. Law P.Y., Wong Y.H., Loh H.H. Molecular mechanisms and regulation of opioid receptor signaling. Annu. Rev. Pharmacol. Toxicol. 2000, 40:389-430.
26. Levran O., Londono D., O'Hara K., Nielsen D.A., Peles E., Rotrosen J., Casadonte P., Linzy S., Randesi M., Ott J., Adelson M., Kreek M.J. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008, 7:720-729.
27. Loh el W., Fann C.S., Chang Y.T., Chang C.J., Cheng A.T. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol. Clin. Exp. Res. 2004, 28:15-19.
28. Luo X., Zuo L., Kranzler H., Zhang H., Wang S., Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2008, 147B:1028-1039.
29. Marin S., Marco E., Biscaia M., Fernandez B., Rubio M., Guaza C., Schmidhammer H., Viveros M.P. Involvement of the kappa-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats. Pharmacol. Biochem. Behav. 2003, 74:649-656.
30. Matthes H.W., Maldonado R., Simonin F., Valverde O., Slowe S., Kitchen I., Befort K., Dierich A., Le Meur M., Dolle P., Tzavara E., Hanoune J., Roques B.P., Kieffer B.L. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996, 383:819-823.
31. Mayer P., Rochlitz H., Rauch E., Rommelspacher H., Hasse H.E., Schmidt S., Hollt V. Association between a delta opioid receptor gene polymorphism and heroin dependence in man. Neuroreport 1997, 8:2547-2550.
32. Merikangas K.R., Stolar M., Stevens D.E., Goulet J., Preisig M.A., Fenton B., Zhang H., O'Malley S.S., Rounsaville B.J. Familial transmission of substance use disorders. Arch. Gen. Psychiatry 1998, 55:973-979.
33. Milligan G. Opioid receptors and their interacting proteins. Neuromolecular Med. 2005, 7:51-59.
34. Nelson E.C., Lynskey M.T., Heath A.C., Wray N., Agrawal A., Shand F.L., Henders A.K., Wallace L., Todorov A.A., Schrage A.J., Madden P.A., Degenhardt L., Martin N.G., Montgomery G.W. Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. Addict. Biol. 2012, (Epub ahead of print).
35. Perrine S.A., Hoshaw B.A., Unterwald E.M. Delta opioid receptor ligands modulate anxiety-like behaviors in the rat. Br. J. Pharmacol. 2006, 147:864-872.
36. Perrine S.A., Sheikh I.S., Nwaneshiudu C.A., Schroeder J.A., Unterwald E.M. Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat. Neuropharmacology 2008, 54:355-364.
37. Pradhan A.A., Befort K., Nozaki C., Gaveriaux-Ruff C., Kieffer B.L. The delta opioid receptor: an evolving target for the treatment of brain disorders. Trends Pharmacol. Sci. 2011, 32:581-590.
38. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., Maller J., Sklar P., de Bakker P.I., Daly M.J., Sham P.C. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81:559-575.
39. Ragnauth A., Schuller A., Morgan M., Chan J., Ogawa S., Pintar J., Bodnar R.J., Pfaff D.W. Female preproenkephalin-knockout mice display altered emotional responses. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:1958-1963.
40. Saxon A.J., Oreskovich M.R., Brkanac Z. Genetic determinants of addiction to opioids and cocaine. Harvard Rev. Psychiatry 2005, 13:218-232.
41. Smith R.J., Doyle G.A., Han A.M., Crowley J.J., Oslin D.W., Patkar A.A., Mannelli P., Demaria P.A., O'Brien C., Berrettini P.W.H. Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2005, 133B:105-109.
42. Sora I., Takahashi N., Funada M., Ujike H., Revay R.S., Donovan D.M., Miner L.L., Uhl G.R. Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:1544-1549.
43. Szeto C.Y., Tang N.L., Lee D.T., Stadlin A. Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. Neuroreport 2001, 12:1103-1106.
44. Tan E.C., Tan C.H., Karupathivan U., Yap E.P. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 2003, 14:569-572.
45. Tsuang M.T., Lyons M.J., Meyer J.M., Doyle T., Eisen S.A., Goldberg J., True W., Lin N., Toomey R., Eaves L. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch. Gen. Psychiatry 1998, 55:967-972.
46. Xu K., Liu X.H., Nagarajan S., Gu X.Y., Goldman D. Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. Am. J. Med. Genet. 2002, 110:45-50.
47. Xuei X., Flury-Wetherill L., Bierut L., Dick D., Nurnberger J., Foroud T., Edenberg H.J. The opioid system in alcohol and drug dependence: family-based association study. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2007, 144B:877-884.
48. Yuferov V., Levran O., Proudnikov D., Nielsen D.A., Kreek M.J. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann. N. Y. Acad. Sci. 2010, 1187:184-207.
49. Zaki P.A., Bilsky E.J., Vanderah T.W., Lai J., Evans C.J., Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annu. Rev. Pharmacol. Toxicol. 1996, 36:379-401.
50. Zhang H., Kranzler H.R., Yang B.Z., Luo X., Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol. Psychiatry 2008, 13:531-543.
51. Zhang H., Luo X., Kranzler H.R., Lappalainen J., Yang B.Z., Krupitsky E., Zvartau E., Gelernter J. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum. Mol. Genet. 2006, 15:807-819.
52. Zhu Y., King M.A., Schuller A.G., Nitsche J.F., Reidl M., Elde R.P., Unterwald E., Pasternak G.W., Pintar J.E. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 1999, 24:243-252.