Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 7, 2008, Pages 1028-1039

  Luo, Xingguang ^a,b   Zuo, Lingjun ^a,b   Kranzler, Henry ^c   Zhang, Huiping ^a,b   Wang, Shuang ^d   Gelernter, Joel ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^d Columbia University ^*  (United States)

Author keywords

OPR genes; Personality; Substance dependence

Indexed keywords

DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE RECEPTOR;

ADULT; AFRICAN AMERICAN; ARTICLE; EUROPEAN AMERICAN; FEMALE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERSONALITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MALE; MIDDLE AGED; PERSONALITY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SUBSTANCE-RELATED DISORDERS; UNITED STATES;

EID: 47749103859     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30701     Document Type: Article

References (44)

1. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders 4th edition. Washington, DC: American Psychiatric Press.
2. Barrett J, Fry B, Maller J, Daly M. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
3. Blouin AG, Perez EL, Blouin JH. 1988. Computerized administration of the diagnostic interview schedule. Psychiatry Res 23:335-344.
4. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L. 1998. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc Natl Acad Sci USA 95:9608-9613.
5. Charness ME. 1989. Ethanol and opioid receptor signaling. Experientia 45:418-428 (Review).
6. Cloninger CR. 1987. Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416.
7. Costa PT, McCrae RR. 1997. Stability and change in personality assessment: The revised NEO Personality Inventory in the year 2000. J Pers Assess 68:86-94.
8. Costa PT, McCrae RR, Dye DA. 1991. Facet scales for agreeableness and conscientiousness: A revision of the NEO Personality inventory. Pers Indiv Differ 12:887-898.
9. Depue RA, Collins PF. 1999. Neurobiology of the structure of personality: Dopamine, facilitation of incentivemotivation, and extraversion. Behav Brain Sci 22:491-517.
10. Di Chiara G, Imperato A. 1988. Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244:1067-1080.
11. Digman JM. 1990. Personality structure: Emergence of the five-factor model. Annu Rev Psychol 41:417-440.
12. Gelernter J, Kranzler HR. 2000. Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Hum Genet 107:86-88.
13. Gianoulakis C, Barcomb A. 1987. Effect of acute ethanol in vivo and in vitro on the beta-endorphin system in the rat. Life Sci 40:19-28.
14. Gray JA. 1970. The psychophysiological basis of introversion- extraversion. Behav Res Ther 8:249-266.
15. Hernandez-Avila CA, Covault J, Gelernter J, Kranzler HR. 2004. Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1). Psychiatr Genet 14:89-92.
16. Herz A. 1997. Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129:99-111 (Review).
17. Kenna GA, McGeary JE, Swift RM. 2004. Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, part 1. Am J Health Syst Pharm 61:2272-2279 (Review).
18. Kreek MJ. 2000. Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recentmolecular and neurochemical research and future in mainstream medicine. Ann NY Acad Sci 909:186-216 (Review).
19. Luo X, Kranzler HR, Zhao H, Gelernter J. 2003. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Am J Med Genet Part B 120B:97-108.
20. Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. 2004. NOTCH4 gene haplotype is associated with schizophrenia in African-Americans. Biol Psychiatry 55:112-117.
21. Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J. 2005a. CHRM2 gene predisposes to alcohol dependence, drug dependence, and affective disorders: Results from an extended case-control structured association study. Hum Mol Genet 14:2421-2434.
22. Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. 2005b. ADH4 gene variation is associated with alcohol and drug dependence in European Americans: Results from family-controlled and population-structured association studies. Pharmacogenetics Genomics 15:755-768.
23. Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. 2007a. CHRM2 variation predisposes to personality traits of Agreeableness and Conscientiousness. Hum Mol Genet 16:1557-1568.
24. Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J. 2007b. Personality traits of agreeableness and extraversion are associated with ADH4 variation. Biol Psychiatry 61:599-608.
25. Mayer P, Rochlitz H, Rauch E, Rommelspacher H, Hasse HE, Schmidt S, Höllt V. 1997. Association between a delta opioid receptor gene polymorphism and heroin dependence in man. Neuroreport 8:2547-2550.
26. McCrae RR, Costa PT. 1997. Personality trait structure as a human universal. Am Psychol 52:509-516.
27. Nyholt DR. 2004. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769.
28. Prisinzano TE, Tidgewell K, Harding WW. 2005. Kappa opioids as potential treatments for stimulant dependence. AAPS J 7:E592-E599 (Review).
29. Przewłocka B, Lason W, Przewlocki R. 1992. Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus. Neurosci Lett 134:195-198.
30. Rapaka RS, Renugopalakrishnan V, Goehl TJ, Collins BJ. 1986a. Ethanol induced conformational changes of the peptide ligands for the opioid receptors and their relevance to receptor interaction. Life Sci 39:837-842.
31. Rapaka RS, Bhargava HN, Renugopalakrishnan V, Collins BJ. 1986b. Molecular mechanisms of ligand binding to opioid receptors: Selective inhibition by ethanol? NIDA Res Monogr 75:355-358.
32. Spanagel R, Herz A, Shippenberg TS. 1992. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89:2046-2050.
33. Spitzer RL, Williams JBW, Gibbon M, First MB. 1992. The structured clinical interview for DSM-III-R (SCID), I: History, rationale, and description. Arch Gen Psychiatry 49:624-629.
34. Srisurapanont M, Jarusuraisin N. 2005. Opioid antagonists for alcohol dependence. Cochrane Database Sys Rev 1:CD001867.
35. Stein MB, Schork NJ, Gelernter J. 2004. A polymorphism of the β1-adrenergic receptor is associated with shyness and low extraversion. Biol Psychiatry 56:217-224.
36. Stein MB, Fallin MD, Schork NJ, Gelernter J. 2005. COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology 30:2092-2102.
37. Tabachnick BG, Fidell LS. 1996. Using multivariate statistics 3rd edition. New York, USA: HarperCollins College Publishers, New York.
38. Trachtenberg MC, Blum K. 1987. Alcohol and opioid peptides: Neuropharmacological rationale for physical craving of alcohol. Am J Drug Alcohol Abuse 13:365-372 (Review).
39. Turchan J, Przewlocka B, Toth G, Lason W, Borsodi A, Przewlocki R. 1999. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience 91:971-977.
40. Wand GS, McCaul M, Yang X, Reynolds J, Gotjen D, Lee S, Ali A. 2002. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 26:106-114.
41. Yang BZ, Zhao H, Kranzler HR, Gelernter J. 2005. Population group assignment: Effects of markers and methods. Genet Epidemiol 28:302-312.
42. Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. 2004. Redefinition of thehuman kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics 14:793-804.
43. Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. 2006. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet 15:807-819.
44. Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. (in press). The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol Psychiatry DOI: 10.1038/sj.mp.4002035.