Resveratrol inhibits mucin gene expression, production and secretion from airway epithelial cells

Phytotherapy Research

Volumn 26, Issue 7, 2012, Pages 1082-1087

  Lee, Su Yel ^a   Lee, Hyun Jae ^a   Sikder, Md Asaduzzaman ^a   Shin, Hyun Dae ^b   Kim, Jang Hyun ^c   Chang, Gyu Tae ^d   Seok, Jeong Ho ^a   Lee, Choong Jae ^a  

^a Chungnam National University   (South Korea)

^b Chungnam National University College of Medicine   (South Korea)

^c Dongguk University   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

airway; mucin; resveratrol

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN P65; MUCIN; MUCIN 5AC; PHORBOL 13 ACETATE 12 MYRISTATE; RESVERATROL; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; MUC5AC GENE; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TRACHEAL SURFACE EPITHELIAL CELL; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; MALE; MUCIN 5AC; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; STILBENES; TETRADECANOYLPHORBOL ACETATE; TRACHEA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84863722126     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3701     Document Type: Review

References (32)

1. Birrell MA, McCluskie K, Wong S, Donnelly LE, Barnes PJ, Belvisi MG,. 2005. Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent mechanism. FASEB J 19: 840-841.
2. Cohn L, Whittaker L, Niu N, Homer RJ,. 2002. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp 248: 201-213.
3. Deng YH, Alex D, Huang HQ, et al,. 2011. Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4'- trimethoxystilbene. Phytother Res 25: 451-457.
4. Donnelly LE, Newton R, Kennedy GE, et al,. 2004. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 287: L774-L783.
5. Fischer BM, Rochelle LG, Voynow JA, Akley NJ, Adler KB,. 1999. TNF-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. Am J Respir Cell Mol Biol 20: 413-422.
6. Gordon JL,. 1986. Extracellular ATP: effects, sources and fate. Biochem J 233: 309-319.
7. Heo HJ, Kim C, Lee HJ, et al,. 2007a. Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. Phytother Res 21: 462-465.
8. Heo HJ, Lee HJ, Kim YS, et al,. 2007b. Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. Phytother Res 21: 1130-1134.
9. Heo HJ, Lee SY, Lee MN, Lee HJ, Seok JH, Lee CJ,. 2009. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother Res 23: 1458-1461.
10. Hewson CA, Edbrooke MR, Johnston SL,. 2004. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells via PKC, EGF/TGF-alpha, Ras/Raf, MEK, REK and Sp1-dependent mechanisms. J Mol Biol 344: 683-695.
11. Hong DH, Petrovics G, Anderson WB, Forstner J, Forstner G,. 1999. Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon. Am J Physiol 277: G1041-G1047.
12. 2-exposed rats. Eur J Pharmacol 487: 7-15.
13. Kim KC, McCracken K, Lee BC, et al,. 1997. Airway goblet cell mucin: its structure and regulation of secretion. Eur Respir J 10: 2644-2649.
14. Ko KH, Lee CJ, Shin CY, Jo M, Kim KC,. 1999. Inhibition of mucin release from airway goblet cells by polycationic peptides. Am J Physiol 277: L811-L815.
15. Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I,. 2008. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 294: L478-L488.
16. Kohri K, Ueki IF, Shim JJ, et al,. 2002. Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J 20: 1263-1270.
17. Kumar A, Sharma SS,. 2010. NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem Biophys Res Commun 394: 360-365.
18. Lee CJ, Lee JH, Seok JH, et al,. 2003. Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. Planta Med 69: 523-526.
19. Lee CJ, Lee JH, Seok JH, et al,. 2004a. Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells. Phytother Res 18: 301-305.
20. Lee CJ, Seok JH, Hur GM, et al,. 2004b. Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. Planta Med 70: 1119-1122.
21. Lee M, Kim S, Kwon OK, Oh SR, Lee HK, Ahn K,. 2009. Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma. Int Immunopharmacol 9: 418-424.
22. Li JD, Dohrman AF, Gallup M, et al,. 1997. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA 94: 967-972.
23. Liu PL, Tsai JR, Charles AL, et al,. 2010. Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases. Mol Nutr Food Res 54 (Suppl 2): S196-S204.
24. Park SJ, Kang SY, Kim NS, Kim HM,. 2002. Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells. Immunopharmacol Immunotoxicol 24: 211-226.
25. Rogers DF, Barnes PJ,. 2006. Treatment of airway mucus hypersecretion. Ann Med 38: 116-125.
26. Shao MX, Ueki IF, Nadel JA,. 2003. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci USA 100: 11618-11623.
27. Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y,. 2003. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am J Respir Crit Care Med 168: 581-587.
28. Song KS, Lee WJ, Chung KC, et al,. 2003. IL-1beta and TNF-alpha induced MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinase-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 278: 23243-23250.
29. Takeyama K, Dabbagh K, Lee HM, et al,. 1999. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 96: 3081-3086.
30. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA,. 2000. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol 164: 1546-1552.
31. Voynow JA, Rubin BK,. 2009. Mucins, mucus and sputum. Chest 135: 505-512.
32. Wasano K, Kim KC, Niles RM, Brody JS,. 1988. Membrane differentiation markers of airway epithelial secretory cells. J Histochem Cytochem 36: 167-178.