Irbesartan promotes erection recovery after nerve-sparing radical retropubic prostatectomy: A retrospective long-term analysis

BJU International

Volumn 110, Issue 11, 2012, Pages 1782-1786

  Segal, Robert L ^a   Bivalacqua, Trinity J ^a   Burnett, Arthur L ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

erectile dysfunction; irbesartan; penile rehabilitation; radical prostatectomy

Indexed keywords

IRBESARTAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPISTAXIS; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MALE; MALE GENITAL TRACT PARAMETERS; MUSCLE CRAMP; NERVE SPARING RADICAL RETROPUBIC PROSTATECTOMY; PENIS; PENIS ERECTION; PRIORITY JOURNAL; PROSTATECTOMY; RETROSPECTIVE STUDY; STRETCHED PENILE LENGTH;

EID: 84870880806     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2012.11098.x     Document Type: Article

References (29)

1. Jemal A, Siegel R, Xu J, Ward E,. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277-300
2. Litwin MS, Flanders SC, Pasta DJ, Stoddard ML, Lubeck DP, Henning JM,. Sexual function and bother after radical prostatectomy or radiation for prostate cancer: multivariate quality-of-life analysis from CaPSURE. Endeavor Urol 1999; 54: 503-8
3. Walz J, Burnett AL, Costello AJ, et al,. A critical analysis of the current knowledge of surgical anatomy related to optimization of cancer control and preservation of continence and erection in candidates for radical prostatectomy. Eur Urol 2010; 57: 179-92
4. Walsh PC, Donker PJ,. Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 1982; 128: 492-7
5. Xylinas E, Durand X, Ploussard G, et al,. Evaluation of combined oncologic and functional outcomes after robotic-assisted laparoscopic extraperitoneal radical prostatectomy: trifecta rate of achieving continence, potency and cancer control. Urol Oncol 2011; [Epub ahead of print]
6. User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT,. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003; 169: 1175-9
7. Mooreland RB,. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 1998; 10: 113-20
8. Iacono F, Gianella R, Somma P, Manno G, Fusco F, Mirone V,. Histological alterations in cavernous tissue after radical prostatectomy. J Urol 2005; 173: 1673-6
9. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW,. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74: 1141-8
10. Rajagopalan S, Kurz S, Munzel T, et al,. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 1996; 97: 1916-23
11. Wassmann S, Czech T, van Eickels M, Fleming I, Bohm M, Nickenig G,. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 2004; 110: 3062-7
12. Canguven O, Lagoda G, Sezen SF, Burnett AL,. Losartan preserves erectile function after bilateral cavernous nerve injury via antifibrotic mechanisms in male rats. J Urol 2009; 181: 2816-22
13. Ruiz-Ortega M, Ruperez M, Esteban V, Egido J,. Molecular mechanisms of angiotensin II-induced vascular injury. Curr Hypertens Rep 2003; 5: 73-9
14. Belmadani S, Bernal J, Wei CC, et al,. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol 2007; 171: 777-89
15. Massagua J, Blain SW, Lo RS,. TGF beta signalling in growth control, cancer and heritable disorders. Cell 2000; 103: 295-309
16. Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M,. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005; 111: 2509-17
17. Segal R, Burnett AL,. Erectile preservation following radical prostatectomy. Ther Adv Urol 2011; 3: 35-46
18. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM,. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319-26
19. Munding M, Wessells H, Dalkin B,. Pilot study of changes in stretched penile length 3 months after radical retropubic prostatectomy. Urol 2001; 58: 567-9
20. Savoie M, Sandy S, Soloway M,. A prospective study measuring penile length in men treated with radical prostatectomy for prostate cancer. J Urol 2003; 169: 1462-4
21. Fraiman M, McCullough A, Lepor H,. Changes in penile morphometrics in men with erectile dysfunction after nerve sparing radical retropubic prostatectomy. Mol Urol 1999; 3: 109-15
22. Gontero P, Galzerano M, Bartoletti R, et al,. New insights into the pathogenesis of penile shortening after radical prostatectomy and the role of postoperative sexual function. J Urol 2007; 178: 602-7
23. Tobili JE, Stella I, Mazza ON, Ferder L, Inserra F,. Candesartan cilexil protects cavernous tissue in spontaneously hypertensive rats. Int J Impot Res 2004; 16: 305-12
24. Baumhäkel M, Custodis F, Schlimmer N, Laufs U, Böhm M,. Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan. J Pharmacol Exp Ther 2008; 327: 692-8
25. Yang R, Yang B, Wen Y, et al,. Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-angiotensin system in streptozocin-induced diabetic rats. J Sex Med 2009; 6: 696-707
26. Schlimmer N, Kratz M, Böhm M, Baumhäkel M,. Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis. Br J Pharm 2011; 163: 804-14
27. Baumhäkel M, Schlimmer N,. Böhm M on behalf of the DO-IT investigators. Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome. Int J Impot Res 2008; 20: 493-500
28. Sola S, Mir MQ, Cheema FA, et al,. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 2005; 111: 343-8
29. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B, Dietz HC III,. Angiotensin II blockade and aortic-root dilation in Marfan's syndrome. NEJM 2008; 358: 2787-95