메뉴 건너뛰기




Volumn 181, Issue 6, 2009, Pages 2816-2822

Losartan Preserves Erectile Function After Bilateral Cavernous Nerve Injury via Antifibrotic Mechanisms in Male Rats

Author keywords

angiotensin II; erectile dysfunction; fibrosis; losartan; penis

Indexed keywords

ALPHA ACTIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; FIBRONECTIN; LOSARTAN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 67349099471     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.01.097     Document Type: Article
Times cited : (48)

References (20)
  • 2
    • 0037362915 scopus 로고    scopus 로고
    • Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction
    • User H.M., Hairston J.H., Zelner D.J., McKenna K.E., and McVary K.T. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 169 (2003) 1175
    • (2003) J Urol , vol.169 , pp. 1175
    • User, H.M.1    Hairston, J.H.2    Zelner, D.J.3    McKenna, K.E.4    McVary, K.T.5
  • 3
    • 0034958068 scopus 로고    scopus 로고
    • Traumatic arteriogenic erectile dysfunction: a rat model
    • El-Sakka A., Yen T.S., Lin C.S., and Lue T.F. Traumatic arteriogenic erectile dysfunction: a rat model. Int J Impot Res 13 (2001) 162
    • (2001) Int J Impot Res , vol.13 , pp. 162
    • El-Sakka, A.1    Yen, T.S.2    Lin, C.S.3    Lue, T.F.4
  • 4
    • 17144364721 scopus 로고    scopus 로고
    • Histological alterations in cavernous tissue after radical prostatectomy
    • Iacono F., Giannella R., Somma P., Manno G., Fusco F., and Mirone V. Histological alterations in cavernous tissue after radical prostatectomy. J Urol 173 (2005) 1673
    • (2005) J Urol , vol.173 , pp. 1673
    • Iacono, F.1    Giannella, R.2    Somma, P.3    Manno, G.4    Fusco, F.5    Mirone, V.6
  • 5
    • 0028010788 scopus 로고
    • Tissue angiotensin system in cardiovascular medicine. A paradigm shift?
    • Dzau V.J., and Re R. Tissue angiotensin system in cardiovascular medicine. A paradigm shift?. Circulation 89 (1994) 493
    • (1994) Circulation , vol.89 , pp. 493
    • Dzau, V.J.1    Re, R.2
  • 6
    • 0036763319 scopus 로고    scopus 로고
    • The angiotensin II receptor blockers: opportunities across the spectrum of cardiovascular disease
    • Weber M.A. The angiotensin II receptor blockers: opportunities across the spectrum of cardiovascular disease. Rev Cardiovasc Med 3 (2002) 183
    • (2002) Rev Cardiovasc Med , vol.3 , pp. 183
    • Weber, M.A.1
  • 9
    • 34548827039 scopus 로고    scopus 로고
    • A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II
    • Belmadani S., Bernal J., Wei C.C., Pallero M.A., Dell'italia L., Murphy-Ullrich J.E., et al. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol 171 (2007) 777
    • (2007) Am J Pathol , vol.171 , pp. 777
    • Belmadani, S.1    Bernal, J.2    Wei, C.C.3    Pallero, M.A.4    Dell'italia, L.5    Murphy-Ullrich, J.E.6
  • 10
    • 0034644472 scopus 로고    scopus 로고
    • TGF beta signaling in growth control, cancer, and heritable disorders
    • Massague J., Blain S.W., and Lo R.S. TGF beta signaling in growth control, cancer, and heritable disorders. Cell 103 (2000) 295
    • (2000) Cell , vol.103 , pp. 295
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 11
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism
    • Rodriguez-Vita J., Sanchez-Lopez E., Esteban V., Ruperez M., Egido J., and Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 111 (2005) 2509
    • (2005) Circulation , vol.111 , pp. 2509
    • Rodriguez-Vita, J.1    Sanchez-Lopez, E.2    Esteban, V.3    Ruperez, M.4    Egido, J.5    Ruiz-Ortega, M.6
  • 12
    • 0346848798 scopus 로고    scopus 로고
    • Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury
    • Burnett A.L., and Becker R.E. Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury. J Urol 171 (2004) 495
    • (2004) J Urol , vol.171 , pp. 495
    • Burnett, A.L.1    Becker, R.E.2
  • 13
    • 34447498964 scopus 로고    scopus 로고
    • FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms
    • Lagoda G., Jin L., Lehrfeld T.J., Liu T., and Burnett A.L. FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms. J Sex Med 4 (2007) 908
    • (2007) J Sex Med , vol.4 , pp. 908
    • Lagoda, G.1    Jin, L.2    Lehrfeld, T.J.3    Liu, T.4    Burnett, A.L.5
  • 14
    • 33748939751 scopus 로고    scopus 로고
    • IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
    • Moon J.A., Kim H.T., Cho I.S., Sheen Y.Y., and Kim D.K. IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int 70 (2006) 1234
    • (2006) Kidney Int , vol.70 , pp. 1234
    • Moon, J.A.1    Kim, H.T.2    Cho, I.S.3    Sheen, Y.Y.4    Kim, D.K.5
  • 15
    • 0030893387 scopus 로고    scopus 로고
    • Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum
    • Kifor I., Williams G.H., Vickers M.A., Sullivan M.P., Jodbert P., and Dluhy R.G. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J Urol 157 (1997) 1920
    • (1997) J Urol , vol.157 , pp. 1920
    • Kifor, I.1    Williams, G.H.2    Vickers, M.A.3    Sullivan, M.P.4    Jodbert, P.5    Dluhy, R.G.6
  • 16
    • 34548312391 scopus 로고    scopus 로고
    • Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan
    • Toblli J.E., Cao G., Lombrana A., and Rivero M. Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan. J Sex Med 4 (2007) 1291
    • (2007) J Sex Med , vol.4 , pp. 1291
    • Toblli, J.E.1    Cao, G.2    Lombrana, A.3    Rivero, M.4
  • 17
    • 33645672459 scopus 로고    scopus 로고
    • Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    • Habashi J.P., Judge D.P., Holm T.M., Cohn R.D., Loeys B.L., Cooper T.K., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312 (2006) 117
    • (2006) Science , vol.312 , pp. 117
    • Habashi, J.P.1    Judge, D.P.2    Holm, T.M.3    Cohn, R.D.4    Loeys, B.L.5    Cooper, T.K.6
  • 19
    • 4344571999 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta1 in penile tissue from rats with bilateral cavernosal nerve ablation
    • Hu W.L., Hu L.Q., Li S.W., Zheng X.M., and Tian B.C. Expression of transforming growth factor-beta1 in penile tissue from rats with bilateral cavernosal nerve ablation. BJU Int 94 (2004) 424
    • (2004) BJU Int , vol.94 , pp. 424
    • Hu, W.L.1    Hu, L.Q.2    Li, S.W.3    Zheng, X.M.4    Tian, B.C.5
  • 20
    • 34247539528 scopus 로고    scopus 로고
    • A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
    • Brown K.A., Pietenpol J.A., and Moses H.L. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 101 (2007) 9
    • (2007) J Cell Biochem , vol.101 , pp. 9
    • Brown, K.A.1    Pietenpol, J.A.2    Moses, H.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.