The rhoptry neck protein RON4 relocalizes at the moving junction during Toxoplasma gondii invasion

Cellular Microbiology

Volumn 7, Issue 12, 2005, Pages 1823-1833

  Lebrun, Maryse ^a   Michelin, Adeline ^a   El Hajj, Hiba ^a   Poncet, Jöel ^b   Bradley, Peter J ^c   Vial, Henri ^a   Dubremetz, Jean François ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b CNRS   (France)

^c Department of Microbiology Immunology and Molecular Genetics ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN RON4; PROTOZOAL PROTEIN; RHOPTRY NECK PROTEIN; UNCLASSIFIED DRUG;

APICOMPLEXA; ARTICLE; CELL JUNCTION; CELL MEMBRANE; CELL VACUOLE; GENETIC CONSERVATION; HOST CELL; HOST PATHOGEN INTERACTION; MASS SPECTROMETRY; MICROBIAL COLONIZATION; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; APICOMPLEXA; CELL LINE; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; ORGANELLES; PROTOZOAN PROTEINS; TOXOPLASMA; TOXOPLASMOSIS;

APICOMPLEXA; TOXOPLASMA GONDII;

EID: 28044454537     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2005.00646.x     Document Type: Article

References (33)

1. Aikawa, M., Miller, L.H., Johnson, J., and Rabbege, J. (1978) Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J Cell Biol 77: 72-82.
2. Aikawa, M., Miller, L.H., Rabbege, J.R., and Epstein, N. (1981) Freeze-fracture study on the erythrocyte membrane during malarial parasite invasion. J Cell Biol 91: 55-62.
3. Bradley, P.J., Ward, C., Cheng, S.J., Alexander, D.L., Coller, S., Coombs, G.H., et al. (2005) Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii. J Biol Chem 280: 34245-34258.
4. Carey, K.L., Jongco, A.M., Kim, K., and Ward, G.E. (2004) The Toxoplasma gondii rhoptry protein ROP4 is secreted into the parasitophorous vacuole and becomes phosphorylated in infected cells. Eukaryot Cell 3: 1320-1330.
5. Carruthers, V.B., and Sibley, L.D. (1997) Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur J Cell Biol 73: 114-123.
6. Carruthers, V.B., and Sibley, L.D. (1999) Mobilization of intra-cellular calcium stimulates microneme discharge in Toxoplasma gondii. Mol Microbiol 31: 421-428.
7. Cossart, P., and Sansonetti, P.J. (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304: 242-248.
8. Dobrowolski, J.M., and Sibley, L.D. (1996) Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 84: 933-939.
9. Dubremetz, J.F., Garcia-Reguet, N., Conseil, V., and Fourmaux, M.N. (1998) Apical organelles and host-cell invasion by Apicomplexa. Int J Parasitol 28: 1007-1013.
10. Garcia-Reguet, N., Lebrun, M., Fourmaux, M.N., Mercereau-Puijalon, O., Mann, T., Beckers, C.J., et al. (2000) The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite. Cell Microbiol 2: 353-364.
11. Hakansson, S., Charron, A.J., and Sibley, L.D. (2001) Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole. EMBO J 20: 3132-3144.
12. Hudson-Taylor, D.E., Dolan, S.A., Klotz, F.W., Fujioka, H., Aikawa, M., Koonin, E.V., and Miller, L.H. (1995) Plasmodium falciparum protein associated with the invasion junction contains a conserved oxidoreductase domain. Mol Microbiol 15: 463-471.
13. Kenny, B., DeVinney, R., Stein, M., Reinscheid, D.J., Frey, E.A., and Finlay, B.B. (1997) Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91: 511-520.
14. Kissinger, J.C., Gajria, B., Li, L., Paulsen, I.T., and Roos, D.S. (2003) ToxoDB: accessing the Toxoplasma gondii genome. Nucleic Acids Res 31: 234-236.
15. Klotz, F.W., Hadley, T.J., Aikawa, M., Leech, J., Howard, R.J., and Miller, L.H. (1989) A 60-kDa Plasmodium falciparum protein at the moving junction formed between merozoite and erythrocyte during invasion. Mol Biochem Parasitol 36: 177-185.
16. Leriche, M.A., and Dubremetz, J.F. (1991) Characterization of the protein contents of rhoptries and dense granules of Toxoplasma gondii tachyzoites by subcellular fractionation and monoclonal antibodies. Mol Biochem Parasitol 45: 249-259.
17. Mann, T., Gaskins, E., and Beckers, C. (2002) Proteolytic processing of TglMC1 during maturation of the membrane skeleton of Toxoplasma gondii. J Biol Chem 277: 41240-41246.
18. Meissner, M., Reiss, M., Viebig, N., Carruthers, V.B., Toursel, C., Tomavo, S., et al. (2002) A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters. J Cell Sci 115: 563-574.
19. Miller, L.H., Aikawa, M., Johnson, J.G., and Shiroishi, T. (1979) Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation. J Exp Med 149: 172-184.
20. Mital, J., Meissner, M., Soldati, D., and Ward, G.E. (2005) Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol Biol Cell 16: 4341-4349.
21. Mitchell, G.H., Thomas, A.W., Margos, G., Dluzewski, A.R., and Bannister, L.H. (2004) Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells. Infect Immun 72: 154-158.
22. Mordue, D.G., and Sibley, L.D. (1997) Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry. J Immunol 159: 4452-4459.
23. Mordue, D.G., Desai, N., Dustin, M., and Sibley, L.D. (1999) Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J Exp Med 190: 1783-1792.
24. Opitz, C., and Soldati, D. (2002) 'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii. Mol Microbiol 45: 597-604.
25. Porchet-Hennere, E., and Torpier, G. (1983) Relations entre Toxoplasma et sa cellule-hote. Protistologica 19, 357-370.
26. Rabenau, K.E., Sohrabi, A., Tripathy, A., Reitter, C., Ajioka, J.W., Tomley, F.M., and Carruthers, V.B. (2001) TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2. Mol Microbiol 41: 537-547.
27. Reiss, M., Viebig, N., Brecht, S., Fourmaux, M.N., Soete, M., Di Cristina, M., et al. (2001) Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii. J Cell Biol 152: 563-578.
28. Roger, N., Dubremetz, J.F., Delplace, P., Fortier, B., Tronchin, G., and Vernes, A. (1988) Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum. Mol Biochem Parasitol 27: 135-141.
29. Saffer, L.D., Mercereau-Puijalon, O., Dubremetz, J.F., and Schwartzman, J.D. (1992) Localization of a Toxoplasma gondii rhoptry protein by immunoelectron microscopy during and after host cell penetration. J Protozool 39: 526-530.
30. Shevchenko, A., Wilm, M., Vorm, O., and Mann, M. (1996) Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858.
31. Soldati, D., Dubremetz, J.F., and Lebrun, M. (2001) Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii. Int J Parasitol 31: 1293-1302.
32. Sultan, A.A., Thathy, V., Frevert, U., Robson, K.J., Crisanti, A., Nussenzweig, V., et al. (1997) TRAP is necessary for gliding motility and infectivity of Plasmodium sporozoites. Cell 90: 511-522.
33. Zhou, X.W., Kafsack, B.F., Cole, R.N., Beckett, P., Shen, R.F., and Carruthers, V.B. (2005) The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins. J Biol Chem 280: 3423-3444.