Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood-brain barrier

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 8, 2011, Pages 1246-1251

  Iwanaga, Kazunori ^a   Yoneda, Shinji ^a   Hamahata, Yukimi ^a   Miyazaki, Makoto ^a   Shibano, Makio ^a   Taniguchi, Masahiko ^a   Baba, Kimiye ^a   Kakemi, Masawo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Blood brain barrier; Furanocoumarin; Inhibition; Kampo medicine; P glycoprotein

Indexed keywords

ANGELICOL; CALCEIN; CALCEIN ACETOXYMETHYL ESTER; CARBAMAZEPINE; FUROCOUMARIN DERIVATIVE; GLYCOPROTEIN P; HERBACEOUS AGENT; KAMPO; RIVULOBIRIN A; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTINUOUS INFUSION; CONTROLLED STUDY; COW; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; MICROVASCULAR ENDOTHELIAL CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SYSTEMIC CIRCULATION;

ANIMALS; APIACEAE; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CACO-2 CELLS; CATTLE; CITRUS PARADISI; COUMARINS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FLUORESCEINS; FURANS; HERB-DRUG INTERACTIONS; HUMANS; INTESTINAL ABSORPTION; MALE; MEDICINE, KAMPO; P-GLYCOPROTEIN; PERMEABILITY; PLANT EXTRACTS; PSORALENS; RATS; RATS, WISTAR; RUTACEAE; VERAPAMIL;

EID: 80051519200     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1246     Document Type: Article

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