Transient deficiency of dendritic cells results in lack of a merozoite surface protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection

Infection and Immunity

Volumn 80, Issue 12, 2012, Pages 4248-4256

  Sponaas, Anne Marit ^a   Belyaev, Nikolai ^a   Falck Hansen, Mika ^a   Potocnik, Alexandre ^a   Langhorne, Jean ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEROZOITE; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM CHABAUDI; PLASMODIUM CHABAUDI INFECTION; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; ERYTHROCYTES; LYMPHOCYTE ACTIVATION; MALARIA; MEROZOITE SURFACE PROTEIN 1; MICE; MICE, INBRED BALB C; PARASITEMIA; PLASMODIUM CHABAUDI;

EID: 84870796243     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00820-12     Document Type: Article

References (48)

1. Adler G, et al. 2011. B and T lymphocyte attenuator restricts the protective immune response against experimental malaria. J. Immunol. 187: 5310-5319.
2. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245-252.
3. Bruna-Romero O, Rodriguez A. 2001. Dendritic cells can intitate protective immune responses against malaria. Infect. Immun. 69:5173-5176.
4. Brunet JF, et al. 1987. A new member of the immunoglobulin superfam-ily CTLA-4. Nature 328:267-270.
5. Chambers CA, et al. 1996. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 153:27-46.
6. Freeman GJ, et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027-1034.
7. Freitas do Rosario AP, et al. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J. Immunol. 188:1178-1190.
8. Green DR, Droin N, Pinkoski M. 2003. Activation-induced cell death in T cells. Immunol. Rev. 193:70-81.
9. Gribben JG, et al. 1995. CTLA4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. U. S. A. 92:811-815.
10. Guntermann C, Alexander DR. 2002. CTLA-4 suppresses proximal TCR signaling in resting human CD4( +) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J. Immunol. 168:4420-4429.
11. Ing R, Segura M, Thawani N, Tarn M, Stevenson MM. 2006. Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation. J. Immunol. 176:441-450.
12. Janeway CA, Jr, Bottomly K. 1994. Signals and signs for lymphocyte responses. Cell 76:275-285.
13. Jankovic D, Kullberg MC, Caspar P, Sher A. 2004. Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J. Immunol. 173:2419-2427.
14. Krieg C, Han P, Stone R, Goularte OD, Kaye J. 2005. Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells. J. Immunol. 175:6420-6427.
15. Lundie RJ. 2011. Antigen presentation in immunity to murine malaria. Curr. Opin. Immunol. 23:119-123.
16. Lundie RJ, et al. 2008. Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 105:14509-14514.
17. Lundie RJ, et al. 2010. Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells. Eur. J. Immunol. 40:1674-1681.
18. Macatonia SE, et al. 1995. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154: 5071-5079.
19. Meding SJ, Cheng SC, Simon-Haarhaus B, Langhorne J. 1990. Role of gamma interferon during infection with Plasmodium chabaudi chabaudi. Infect. Immun. 58:3671-3678.
20. Millington OR, Di Lorenzo C, Phillips RS, Garside P, Brewer JM. 2006. Suppression of adaptive immunity to heterologous antigens during Plas- modium infection through hemozoin-induced failure of dendritic cell function. J. Biol. 5:5.
21. Millington OR, et al. 2007. Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. PLoS Pathol. 3:1380-1387.
22. Murphy TL, Murphy KM. 2010. Slow down and survive: enigmatic immunoregulation by BTLA and HVEM. Annu. Rev. Immunol. 28:389-411.
23. Ocana-Morgner C, Mota M, Rodriguez A. 2003. Malaria blood stage suppression of liver stage immunity by dendritic cells. J. Exp. Med. 197: 143-151.
24. Ocana-Morgner C, et al. 2007. Role of TGF-beta and PGE2 in T cell responses during Plasmodium yoelii infection. Eur. J. Immunol. 37:1562-1574.
25. Orengo JM, et al. 2008. Plasmodium-induced inflammation by uric acid. PLoS Pathol. 4:e1000013. doi:10.1371/journal.ppat.1000013.
26. Perry J, Rush A, Wilson R, Olver C, Avery A. 2004. Dendritic cells from malaria-infected mice are fully functional APC. J. Immunol. 172:475-482.
27. Perry JA, Olver CS, Burnett RC, Avery AC. 2005. The acquisition of TLR tolerance during malaria infection impacts T cell activation. J. Immunol. 174:5921-5925.
28. Quin SJ, et al. 2001. Low CD4(+) T cell responses to the C-terminal region of the malaria merozoite surface protein-1 may be attributed to processing within distinct MHC class II pathways. Eur. J. Immunol. 31:72-81.
29. Rock KL, Shen L. 2005. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol. Rev. 207:166-183.
30. Salomon B, Bluestone JA. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19:225-252.
31. Seixas E, Cross C, Quin S, Langhorne J. 2001. Direct activation of dendritic cells by the malaria parasite, Plasmodium chabaudi chabaudi. Eur. J. Immunol. 31:2970-2978.
32. Slade SJ, Langhorne J. 1989. Production of interferon-gamma during infection of mice with Plasmodium chabaudi chabaudi. Immunobiology 179:353-365.
33. Smith KA. 1988. Interleukin-2: inception, impact, and implications. Science 240:1169-1176.
34. Spence PJ, Langhorne J. 2012. T cell control of malaria pathogenesis. Curr. Opin. Immunol. 24:444-448.
35. Sponaas AM, et al. 2006. Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. J. Exp. Med. 203:1427-1433.
36. Steinman RM, Hemmi H. 2006. Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311:17-58.
37. Stephens R, et al. 2005. Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance. Blood 106:1676-1684
38. Trinchieri G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133-146.
39. Unkeless JC. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580-596.
40. Urban B, et al. 1999. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature 400:73-77.
41. Urban BC, et al. 2001. Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria. Blood 98:2859-2861.
42. Walunas TL, Bakker CY, Bluestone JA. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541-2550.
43. Watanabe N, et al. 2003. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4:670-679.
44. Watts C. 2001. Antigen processing in the endocytic compartment. Curr. Opin. Immunol. 13:26-31.
45. West MA, et al. 2004. Enhanced dendritic cell antigen capture via Tolllike receptor-induced actin remodeling. Science 305:1153-1157.
46. Wilson NS, et al. 2006. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat. Immunol. 7:165-172.
47. Wing K, et al. 2008. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271-275.
48. Wykes MN, Liu XQ, Jiang S, Hirunpetcharat C, Good MF. 2007. Systemic tumor necrosis factor generated during lethal Plasmodium infections impairs dendritic cell function. J. Immunol. 179:3982-3987.