메뉴 건너뛰기




Volumn 7, Issue 12, 2012, Pages

Folate Metabolism Gene 5,10-Methylenetetrahydrofolate Reductase (MTHFR) Is Associated with ADHD in Myelomeningocele Patients

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 84870789678     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051330     Document Type: Article
Times cited : (18)

References (47)
  • 3
    • 78650206677 scopus 로고    scopus 로고
    • Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006
    • Parker S, Mai C, Canfield M, Rickard R, Wang Y, et al. (2010) Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A: Clin Mol Teratol 88(12): 1008-1016.
    • (2010) Birth Defects Res A: Clin Mol Teratol , vol.88 , Issue.12 , pp. 1008-1016
    • Parker, S.1    Mai, C.2    Canfield, M.3    Rickard, R.4    Wang, Y.5
  • 4
    • 84870833164 scopus 로고    scopus 로고
    • Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study
    • Agiopian A, Canfield M, Olney R, Lupo P, Ramadhani T, et al. (2011) Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study. Am J Med Genet Part A. 9999: 1-7.
    • (2011) Am J Med Genet Part A , vol.9999 , pp. 1-7
    • Agiopian, A.1    Canfield, M.2    Olney, R.3    Lupo, P.4    Ramadhani, T.5
  • 5
    • 58149246410 scopus 로고    scopus 로고
    • NINDS NIH, Retrieved November 29, 2011, from
    • NINDS NIH (2007) "Spina bifida fact sheet." Retrieved November 29, 2011, from http://www.ninds.nih.gov/disorders/spina_bifida/detail_spina_bifida.htm.
    • (2007) Spina bifida fact sheet
  • 6
    • 0028814620 scopus 로고
    • Adults with spina bifida and/or hydrocephalus
    • Morgan D, Blackburn M, Bax M, (1995) Adults with spina bifida and/or hydrocephalus. Postgrad Med J 71: 17-21.
    • (1995) Postgrad Med J , vol.71 , pp. 17-21
    • Morgan, D.1    Blackburn, M.2    Bax, M.3
  • 7
    • 21344437736 scopus 로고    scopus 로고
    • Attention problems and executive functions in children with spina bifida and hydrocephalus
    • Burmeister R, Hannay H, Copeland K, Fletcher JM, Boudousquie A, et al. (2005) Attention problems and executive functions in children with spina bifida and hydrocephalus. Child Neuropsych 11: 265-283.
    • (2005) Child Neuropsych , vol.11 , pp. 265-283
    • Burmeister, R.1    Hannay, H.2    Copeland, K.3    Fletcher, J.M.4    Boudousquie, A.5
  • 8
    • 0000091792 scopus 로고    scopus 로고
    • Psychiatric symptomatology and family functioning in children and adolescents with spina bifida
    • Ammerman R, Kane V, Slomka G, Reigel D, Franzen M, et al. (1998) Psychiatric symptomatology and family functioning in children and adolescents with spina bifida. J Clin Psych Med Settings 5: 449-465.
    • (1998) J Clin Psych Med Settings , vol.5 , pp. 449-465
    • Ammerman, R.1    Kane, V.2    Slomka, G.3    Reigel, D.4    Franzen, M.5
  • 9
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: results of the Medical Research Council Vitamin Study
    • MRC Vitamin Study Research Group
    • MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338: 131.
    • (1991) Lancet , vol.338 , pp. 131
  • 11
    • 42549159927 scopus 로고    scopus 로고
    • A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation
    • Kuznetsova AY, Deth RC, (2008) A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. J Comput Neurosci 24: 314-329.
    • (2008) J Comput Neurosci , vol.24 , pp. 314-329
    • Kuznetsova, A.Y.1    Deth, R.C.2
  • 12
    • 0034884178 scopus 로고    scopus 로고
    • Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway
    • Zhao R, Chen Y, Tan W, Waly M, Sharma A, et al. (2001) Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway. J Neurochem 78: 788-796.
    • (2001) J Neurochem , vol.78 , pp. 788-796
    • Zhao, R.1    Chen, Y.2    Tan, W.3    Waly, M.4    Sharma, A.5
  • 13
    • 33748646825 scopus 로고    scopus 로고
    • The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
    • Brookes KJ, Xu X, Chen W, Zhou K, Neale B, et al. (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11: 934-953.
    • (2006) Mol Psychiatry , vol.11 , pp. 934-953
    • Brookes, K.J.1    Xu, X.2    Chen, W.3    Zhou, K.4    Neale, B.5
  • 14
    • 33744455451 scopus 로고    scopus 로고
    • Genetic variation in genes of folate metabolism and neural-tube defect risk
    • van der Linden I, Afman L, Heil S, Blom H, (2006) Genetic variation in genes of folate metabolism and neural-tube defect risk. ProcNutr Soc 65(2): 204-215.
    • (2006) ProcNutr Soc , vol.65 , Issue.2 , pp. 204-215
    • van der Linden, I.1    Afman, L.2    Heil, S.3    Blom, H.4
  • 15
    • 73949160160 scopus 로고    scopus 로고
    • Genetics of human neural tube defects
    • Greene N, Stanier P, Copp A, (2009) Genetics of human neural tube defects. Hum Mol Genet 18(R2): R113-129.
    • (2009) Hum Mol Genet , vol.18 , Issue.R2
    • Greene, N.1    Stanier, P.2    Copp, A.3
  • 16
    • 65349175626 scopus 로고    scopus 로고
    • Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants
    • Harris M (2009). Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants. Birth Defects Research Annals of Clinical Molecular Teratology, 85(4), 331-339.
    • (2009) Birth Defects Research Annals of Clinical Molecular Teratology , vol.85 , Issue.4 , pp. 331-339
    • Harris, M.1
  • 17
    • 0031066138 scopus 로고    scopus 로고
    • Is the common 677C->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis
    • van der Put N, Eskes T, Blom H, (1997) Is the common 677C->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. Quarterly J Med 90(2): 111-115.
    • (1997) Quarterly J Med , vol.90 , Issue.2 , pp. 111-115
    • van der Put, N.1    Eskes, T.2    Blom, H.3
  • 18
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R, (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64(3): 169-172.
    • (1998) Mol Genet Metab , vol.64 , Issue.3 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 19
    • 0032893230 scopus 로고    scopus 로고
    • Analysis of select folate pathway genes, PAX3 and Human T in a midwestern neural tube defect population
    • Trembath D, Sherbondy A, VanDyke D, Shaw G, Todoroff K, et al. (1999) Analysis of select folate pathway genes, PAX3 and Human T in a midwestern neural tube defect population. Teratol 59: 331-341.
    • (1999) Teratol , vol.59 , pp. 331-341
    • Trembath, D.1    Sherbondy, A.2    VanDyke, D.3    Shaw, G.4    Todoroff, K.5
  • 20
    • 49949152394 scopus 로고    scopus 로고
    • Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and diskinesias in CNS folate deficiency
    • Moretti P, Peters S, Del Gaudio D, Sahoo T, Hyland K, et al. (2008) Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and diskinesias in CNS folate deficiency. J Autism Develop Disord, 38(6), 1170-1177.
    • (2008) J Autism Develop Disord , vol.38 , Issue.6 , pp. 1170-1177
    • Moretti, P.1    Peters, S.2    Del Gaudio, D.3    Sahoo, T.4    Hyland, K.5
  • 21
    • 0035050096 scopus 로고    scopus 로고
    • Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    • Morris M, Jacques P, Rosenberg I, Selhub J, (2001) Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 73(5): 927-933.
    • (2001) Am J Clin Nutr , vol.73 , Issue.5 , pp. 927-933
    • Morris, M.1    Jacques, P.2    Rosenberg, I.3    Selhub, J.4
  • 22
    • 34548740769 scopus 로고    scopus 로고
    • Plasma folate concentration and cognitive performance: Rotterdam Scan Study
    • de Lau L, Refsum H, Smith A, Johnson C, Breteler M, (2007) Plasma folate concentration and cognitive performance: Rotterdam Scan Study. Am J Clin Nutrit 86(3): 728-734.
    • (2007) Am J Clin Nutrit , vol.86 , Issue.3 , pp. 728-734
    • de Lau, L.1    Refsum, H.2    Smith, A.3    Johnson, C.4    Breteler, M.5
  • 23
    • 55049095215 scopus 로고    scopus 로고
    • Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people
    • Malouf R, Grimley Evans J, (2008) Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Rev 8(4): CD004514.
    • (2008) Cochrane Rev , vol.8 , Issue.4
    • Malouf, R.1    Grimley Evans, J.2
  • 25
    • 70350452169 scopus 로고    scopus 로고
    • Impact of iron-folic acid supplementation on cognitive abilities of school girls in Vadodara
    • Sen A, Kanani S, (2009) Impact of iron-folic acid supplementation on cognitive abilities of school girls in Vadodara. Indian Pediatr 46(2): 849-854.
    • (2009) Indian Pediatr , vol.46 , Issue.2 , pp. 849-854
    • Sen, A.1    Kanani, S.2
  • 26
    • 60549117481 scopus 로고    scopus 로고
    • Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline
    • Tangney C, Tang Y, Evans D, Morris M, (2009) Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurol 72(4): 361-367.
    • (2009) Neurol , vol.72 , Issue.4 , pp. 361-367
    • Tangney, C.1    Tang, Y.2    Evans, D.3    Morris, M.4
  • 27
    • 48849105546 scopus 로고    scopus 로고
    • Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample
    • Bussing R, Fernandez M, Harwood M, Hou W, Garvan C, et al. (2008) Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample. Assessment 15(3): 317-328.
    • (2008) Assessment , vol.15 , Issue.3 , pp. 317-328
    • Bussing, R.1    Fernandez, M.2    Harwood, M.3    Hou, W.4    Garvan, C.5
  • 28
    • 0032753828 scopus 로고    scopus 로고
    • A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Multimodal treatment study of children with ADHD
    • The MTA Cooperative Group
    • The MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56: 1073-1086.
    • (1999) Arch Gen Psychiatry , vol.56 , pp. 1073-1086
  • 29
    • 38949096877 scopus 로고    scopus 로고
    • Genes in glucose metabolism and association with spina bifida
    • Davidson C, Northrup H, King T, Fletcher JM, Townsend I, et al. (2008) Genes in glucose metabolism and association with spina bifida. Reprod Sci 15(1): 51-58.
    • (2008) Reprod Sci , vol.15 , Issue.1 , pp. 51-58
    • Davidson, C.1    Northrup, H.2    King, T.3    Fletcher, J.M.4    Townsend, I.5
  • 30
    • 70349322403 scopus 로고    scopus 로고
    • Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida
    • Martinez D, Northrup H, Jone-Ing L, Morrison A, Fletcher JM, Tyerman M, et al. (2009) Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. Am J Obstet Gynecol 201(394): e1-11.
    • (2009) Am J Obstet Gynecol , vol.201 , Issue.394
    • Martinez, D.1    Northrup, H.2    Jone-Ing, L.3    Morrison, A.4    Fletcher, J.M.5    Tyerman, M.6
  • 31
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a toolset for whole-genome association and population-based linkage analysis
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, et al. (2007) PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 81: 559-575.
    • (2007) Am J Hum Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.R.5
  • 32
    • 79953718498 scopus 로고    scopus 로고
    • Folic acid food fortification - Its history, effect, concerns, and future directions
    • Crider KS, Bailey LB, Berry RJ, (2011) Folic acid food fortification - Its history, effect, concerns, and future directions. Nutrients 3: 370-384.
    • (2011) Nutrients , vol.3 , pp. 370-384
    • Crider, K.S.1    Bailey, L.B.2    Berry, R.J.3
  • 33
    • 39649095363 scopus 로고    scopus 로고
    • Nutritional therapies for mental disorders
    • Lakhan SE, Vieira KF, (2008) Nutritional therapies for mental disorders. Nutr J 7: 2.
    • (2008) Nutr J , vol.7 , pp. 2
    • Lakhan, S.E.1    Vieira, K.F.2
  • 34
    • 33645085559 scopus 로고    scopus 로고
    • A model of neurocognitive function in spina bifida over the life span
    • Dennis M, Landry S, Barnes M, Fletcher JM, (2006) A model of neurocognitive function in spina bifida over the life span. J Intl Neuropsychol Soc 12: 285-296.
    • (2006) J Intl Neuropsychol Soc , vol.12 , pp. 285-296
    • Dennis, M.1    Landry, S.2    Barnes, M.3    Fletcher, J.M.4
  • 35
    • 77951660701 scopus 로고    scopus 로고
    • The cognitive phenotype of spina bifida myelomeningocele
    • Dennis M, Barnes M, (2010) The cognitive phenotype of spina bifida myelomeningocele. Dev Dis Res Rev 16(1): 31-39.
    • (2010) Dev Dis Res Rev , vol.16 , Issue.1 , pp. 31-39
    • Dennis, M.1    Barnes, M.2
  • 36
    • 51349136783 scopus 로고    scopus 로고
    • Puppets, robots, critics, and actors within a taxonomy of attention for developmental disorders
    • Dennis M, Sinopoli K, Fletcher JM, Schachar R, (2008) Puppets, robots, critics, and actors within a taxonomy of attention for developmental disorders. J Intl Neuropsychol Soc 14: 673-690.
    • (2008) J Intl Neuropsychol Soc , vol.14 , pp. 673-690
    • Dennis, M.1    Sinopoli, K.2    Fletcher, J.M.3    Schachar, R.4
  • 37
    • 13844281457 scopus 로고    scopus 로고
    • Covert orienting to exogenous and endogenous cues in children with spina bifida
    • Dennis M, Edelstein K, Copeland K, Frederick J, Francis D, et al. (2005) Covert orienting to exogenous and endogenous cues in children with spina bifida. Neuropsychologia 43(6): 976-987.
    • (2005) Neuropsychologia , vol.43 , Issue.6 , pp. 976-987
    • Dennis, M.1    Edelstein, K.2    Copeland, K.3    Frederick, J.4    Francis, D.5
  • 38
    • 56349142677 scopus 로고    scopus 로고
    • Sustained attention in children with two etiologies of early hydrocephalus
    • Swartwout M, Cirino P, Hampson A, Fletcher JM, Brandt M, et al. (2008) Sustained attention in children with two etiologies of early hydrocephalus. Neuropsych 22(6): 765-775.
    • (2008) Neuropsych , vol.22 , Issue.6 , pp. 765-775
    • Swartwout, M.1    Cirino, P.2    Hampson, A.3    Fletcher, J.M.4    Brandt, M.5
  • 40
    • 0026482332 scopus 로고
    • Long-term neuropsychologic sequelae of childhood leukemia: comparison of two CNS prophylactic regimens
    • Giralt J, Ortega J, Olive T, Verges R, Forio I, et al. (1992) Long-term neuropsychologic sequelae of childhood leukemia: comparison of two CNS prophylactic regimens. Intl J Rad Oncol Biol Phys 24(1): 49-53.
    • (1992) Intl J Rad Oncol Biol Phys , vol.24 , Issue.1 , pp. 49-53
    • Giralt, J.1    Ortega, J.2    Olive, T.3    Verges, R.4    Forio, I.5
  • 41
    • 0027216729 scopus 로고
    • Severe permanent encephalopathy in acute lymphoblastic leukemia
    • Maria B, Dennis M, Obonsawain M, (1993) Severe permanent encephalopathy in acute lymphoblastic leukemia. Can J Neurol Sci 20(3): 199-205.
    • (1993) Can J Neurol Sci , vol.20 , Issue.3 , pp. 199-205
    • Maria, B.1    Dennis, M.2    Obonsawain, M.3
  • 42
    • 37249044154 scopus 로고    scopus 로고
    • Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors
    • Krull K, Brouwers M, Jain N, Zhang L, Bomgaars L, et al. (2008) Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr 152: 101-105.
    • (2008) J Pediatr , vol.152 , pp. 101-105
    • Krull, K.1    Brouwers, M.2    Jain, N.3    Zhang, L.4    Bomgaars, L.5
  • 43
    • 80054726051 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder
    • Gokcen C, Kocak N, Pekgor A, (2011) Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder. Intl J Med Sci 8(7): 523-528.
    • (2011) Intl J Med Sci , vol.8 , Issue.7 , pp. 523-528
    • Gokcen, C.1    Kocak, N.2    Pekgor, A.3
  • 44
    • 84856242112 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder
    • Ergul E, Sazci A, Kara I, (2012) Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder. Genet Test Mol Biomarkers 16(1): 67-69.
    • (2012) Genet Test Mol Biomarkers , vol.16 , Issue.1 , pp. 67-69
    • Ergul, E.1    Sazci, A.2    Kara, I.3
  • 45
    • 84655176643 scopus 로고    scopus 로고
    • Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
    • Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, et al. (2012) Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet 44(1): 78-86.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 78-86
    • Elia, J.1    Glessner, J.T.2    Wang, K.3    Takahashi, N.4    Shtir, C.J.5
  • 46
    • 84884700247 scopus 로고    scopus 로고
    • The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding
    • May 28 [Epub ahead of print]. PMID 22647417
    • Wu C, Gong Y, Sun A, Zhang Y, Zhang C, et al. (2012) The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding. Nutr Metab Cardiovasc Dis May 28 [Epub ahead of print]. PMID 22647417.
    • (2012) Nutr Metab Cardiovasc Dis
    • Wu, C.1    Gong, Y.2    Sun, A.3    Zhang, Y.4    Zhang, C.5
  • 47
    • 84877291541 scopus 로고    scopus 로고
    • Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene
    • 2011 Dec 27. doi: 10.1002/mc.21861. [Epub ahead of print]
    • Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP (2011) Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Mol Carcinog, 2011 Dec 27. doi: 10.1002/mc.21861. [Epub ahead of print].
    • (2011) Mol Carcinog
    • Koturbash, I.1    Melnyk, S.2    James, S.J.3    Beland, F.A.4    Pogribny, I.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.