Identification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) as a Novel Target of Bisphenol A

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Ito, Yuki ^a   Ito, Takumi ^a   Karasawa, Satoki ^a   Enomoto, Teruya ^a   Nashimoto, Akihiro ^a   Hase, Yasuyoshi ^a   Sakamoto, Satoshi ^a   Mimori, Tsuneyo ^b   Matsumoto, Yoshihisa ^a   Yamaguchi, Yuki ^a   Handa, Hiroshi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IONIZING RADIATION; MOLECULAR MECHANICS; PROTEIN INTERACTION; PROTEIN TARGETING; RADIOSENSITIVITY;

ANIMALS; BENZHYDRYL COMPOUNDS; CATALYTIC DOMAIN; DNA-ACTIVATED PROTEIN KINASE; MICE; MUTATION; PHENOLS; RADIATION-SENSITIZING AGENTS;

MAMMALIA;

EID: 84870769674     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050481     Document Type: Article

References (42)

1. Rubin BS, (2011) Biphenol A: An endocrine disruptor with widespread exposure and multiple effects. J. Steroid Biochem. Mol. Biol. 127: 27-34.
2. Le HH, Carlson EM, Chua JP, Belcher SM, (2007) Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol. Lett. 176: 149-156.
3. Milligan SR, Balasubramanian AV, Kalita JC, (1998) Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay. Environ. Health Perspect. 106: 23-26.
4. Maffini MV, Rubin BS, Sonnenschein C, Soto AM, (2006) Endocrine disruptors and reproductive health: the case of bisphenol-A. Mol. Cell. Endocrinol. 25: 179-186.
5. Welshon WV, Thayer KA, Judy BM, Taylor JA, Curran EM, et al. (2003) Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ. Health Perspect. 111: 994-1006.
6. Alonso-Magdalena P, Larbi O, Ropero AB, Fuentes E, Ripoll C, et al. (2005) Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. Environ. Health Perspect. 113: 969-977.
7. Hiroi T, Okada K, Imaoka S, Funae Y, (2006) Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities. Endocrinology 147: 2773-2780.
8. FDA (Food and Drug Administration) (2010) Update on Bisphenol A for use in food contact applications: January 2010. Available: http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm197739.htm [accessed 27 October 2010].
9. Government of Canada (2010) Order adding a toxic substance to schedule 1 to the Canadian Environmental Protection Act, 1999.
10. Stahlhut RW, Welshons WV, Swan SH, (2009) Bisphenol A date in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ. Health Perspect. 117: 784-789.
11. Li D, Zhou Z, Qing D, He Y, Wu T, et al. (2010) Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum. Reprod. 25: 519-527.
12. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, et al. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82: 849-856.
13. Gottlieb TM, Jackson SP, (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72: 131-142.
14. Mahaney BL, Meek K, Lees-Miller SP, (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 417: 639-650.
15. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeor J, et al. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80: 813-823.
16. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, et al. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267: 1178-1183.
17. Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS III, et al. (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267: 1183-1185.
18. Sakamoto S, Kabe Y, Hatakeyama M, Yamaguchi Y, Handa H, (2009) Development and application of high-performance affinity beads: Toward chemical biology and drug discovery. Chem. Rec. 9: 66-85.
19. Dignam JD, Lebovitz RM, Roeder RG, (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acids Res. 11: 1475-1489.
20. Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW, (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly (ADP-ribose) polymerase-1. Cancer Res. 63: 6008-6015.
21. Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, et al. (2005) Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J. Biol. Chem. 280: 14709-14715.
22. Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, et al. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64: 2390-2396.
23. Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, et al. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64: 9152-9159.
24. Kienker LJ, Shin EK, Meek K, (2000) Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res. 28: 2752-2761.
25. Yu Y, Okayasu R, Weil MM, Silver A, McCarthy M, et al. (2001) Elevated breast cancer risk in irradiated BALB/c mice associations with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) Gene. Cancer Res. 61: 1820-1824.
26. Mori N, Matsumoto Y, Okumoto M, Suzuki N, Yamate J, (2001) Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene 2: 3609-3619.
27. Auckley DH, Crowell RE, Heaphy ER, Stidley CA, Lechner JF, et al. (2001) Reduced DNA-dependent protein kinase activity is associated with lung cancer. Carcinogenesis 22: 723-727.
28. Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, et al. (2006) The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. Carcinogenesis 27: 117-122.
29. Zhu H, Xiao X, Zheng J, Zheng S, Dong K, et al. (2009) Growth-promoting effect of bisphenol a on neuroblastoma in vitro and in vivo. J. Pediatr. Surg. 44: 672-680.
30. Prins GS, Tang WY, Belmonte J, Ho SM, (2008) Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated. Fertil Steril 89: e41.
31. Betancourt A, Mobley J, Russo J, Lamartiniere C, (2010) Proteomic analysis in mammary glands of rat offspring exposed in utero to Bisphenol A. J. Proteomics. 73: 1241-1253.
32. Allard P, Colaiácovo MP, (2010) Biphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc. Natl. Acad. Sci. U S A 23: 20405-20410.
33. Zhao Y, Thomas HD, Batey MA, Cowell IG, Richardson CJ, et al. (2006) Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 66: 5354-5362.
34. Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG, (1997) Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eiF2alpha kinase GCN2. Mol. Cell. Biol. 17: 4474-4489.
35. Kundakovic M, Champaqne FA, (2011) Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav. Immun. 25: 1084-1093.
36. Ito T, Ando H, Suzuki T, Ogura T, Hotta K, et al. (2010) Identification of a primary target of thalidomide teratogenicity. Science 327: 1345-1350.
37. Nishio K, Masaike Y, Ikeda M, Narimatsu H, Gokon N, et al. (2008) Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids Surf. B: Biointerfaces 64: 162-169.
38. Matsumoto Y, Suzuki N, Sakai K, Morimatsu A, Hirano K, et al. (1997) A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase. Biophys. Res. Commun. 234: 568-572.
39. Alcaraz C, De Diego M, Pastor MJ, Escribano JM, (1990) Comparison of a radioimmunoprecipitation assay to immunoblotting and ELISA for detection of antibody to African swine fever virus. J. Vet. Diagn. Invest. 2: 191-196.
40. Inomata Y, Kawaguchi H, Hiramoto M, Wada T, Handa H, (1992) Direct purification of multiple ATF/E4TF3 polypeptides from HeLa cell crude nuclear extracts using DNA affinity latex particles. Anal. Biochem. 206: 109-114.
41. Hammarsten O, Chu G, (1998) DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl Acad. Sci. USA. 95: 525-530.
42. Mimori T, Hardin JA, Steitz JA, (1986) Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem. 261: 2274-2278.