Effects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic rats

Turkish Journal of Medical Sciences

Volumn 42, Issue SUPPL.2, 2012, Pages 1406-1413

  Aydin, Muhsin ^a   Çelik, Sefa ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Diabetes; Lycopene; mRNA; Oxidative stress

Indexed keywords

CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INSULIN; LYCOPENE; MALONALDEHYDE; MESSENGER RNA; NITRIC OXIDE; STREPTOZOCIN; SUNFLOWER OIL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; BRAIN LEVEL; BRAIN TISSUE; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; HEMOLYSATE; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; TRANSCRIPTION REGULATION; TREATMENT DURATION; WEIGHT REDUCTION;

EID: 84870756887     PISSN: 13000144     EISSN: None     Source Type: Journal    
DOI: 10.3906/sag-1202-44     Document Type: Article

References (33)

1. Maritim AC, Sanders RA, Watkins JB 3rd. Effect of alpha lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J Nutr Biochem 2003; 14: 288-94.
2. Celik S, Erdogan S, Tuzcu M. Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats. Pharmacol Res 2009; 60: 270-6.
3. Mohammadi J, Saadipour K, Delaviz H, Mohammadi B. Antidiabetic effects of an alcoholic extract of Juglans regia in an animal model. Turk J Med Sci 2011; 41: 685-91.
4. Usha Nandhini R, Muthiah PL, Stalin C. Evaluation of antioxidant activity of flowers and leaves of Cassia auriculata Linn. Int J Phytophar Res 2011; 2: 1-4.
5. Aǧar G, Aslan A, Kotan Sarioǧlu E, Alpsoy L, Çeker S. Protective activity of the methanol extract of Usnea longissima against oxidative damage and genotoxicity caused by aflatoxin Bj in vitro. Turk J Med Sci 2011; 41: 1044-9.
6. Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR. Type 2 diabetes mellitus as a conformation disease. J Pancreas 2005; 6: 287-302.
7. Memişoǧullari R, Bakan E. Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with type 2 diabetes mellitus. J Diabetes Complications 2004; 18: 193-7.
8. Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 2000; 26: 163-76.
9. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takanashi H. Glucose toxicity in beta-cell: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003; 52: 581-7.
10. Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 2005; 57: 90-6.
11. Duzguner V, Kucukgul A, Erdogan S, Celik S, Sahin K. Effect of lycopene administration on plasma glucose, oxidative stress and body weight in streptozotocin diabetic rats. J Appl Anim Res 2008; 33: 17-20.
12. Rao AV, Agarwal S. Role of antioxidant lycopene in cancer and heart disease. J Am Coll Nutr 2000; 19: 563-9.
13. Latha M, Pari L. Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes. Braz J Med Biol Res 2004; 37: 577-86.
14. Jonker D, Kuper CF, Frail N, Estrella A, Rodriguez O.C. Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regul Toxicol Pharmacol 2003; 37: 396-406.
15. Drabkin DL. The crystallographic and optical properties of the hemoglobin of man in comparison with those of other species. J Biol Chem 1946; 146: 703-23.
16. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
17. Yoshoiko T, Kawada K, Shimada T, Mori M. Lipid peroxidation in maternal and cord blood and protective mechanism against active-oxygen toxicity in the blood. Am J Obstet Gynecol 1979; 135: 372-6.
18. Luck H. Catalase. In: Bergmeyer HU, editor. Methods in enzyme analysis. Weinheim, Germany: Verlag Chemie; 1965.
19. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
20. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968; 25: 192-205.
21. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990; 36: 440-3.
22. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte GSH-Px. J Lab Clin Med 1967; 70: 158-69.
23. Bhor VM, Raghuram N, Sivakami S. Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats. Int J Biochem Cell Biol 2004; 36: 89-97.
24. Zangen SW, Ryu S, Ornoy A. Alterations in the expression of antioxidant genes and the levels of transcriptions factor NF-kappa B in relation to diabetic embryopathy in the Cohen diabetic rat model. Birth Defects Res A Clin Mol Teratol 2006; 76: 107-14.
25. Kostic MM, Erdogan S, Rena G, Borchert G, Hoch B, Bartel S et al. Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart. J Mol Cell Cardiol 1997; 29: 3135-46.
26. Mellert W, Deckardt K, Gembardt C, Schulte S, Van Ravenzwaay B, Slesinski R. Thirteen-week oral toxicity study of synthetic lycopene products in rats. Food Chem Toxicol 2002; 40: 1581-8.
27. Sindhu RK, Koo R, Roberts CK, Vaziri ND. Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes: response to insulin and antioxidant therapy. Clin Exp Hypertension 2004; 26: 43-53.
28. Quinn L. Mechanism in the development of type 2 diabetes mellitus. J Cardiovas Nursing 2002; 16: 1-16.
29. Dixon ZR, Shie FS, Warden BA, Burri BJ, Neidlinger TR. The effect of a low carotenoid diet on malondialdehyde-thiobarbituric acid (MDA-TBA) concentrations in women: a placebo-controlled double-blind study. J Am Coll Nutr 1998; 17: 54-8.
30. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and P-cell dysfunction? Diabetes 2003; 52: 1-8.
31. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004; 24: 816-23.
32. Welsh N, Eizirik DL, Sandler S. Nitric oxide and pancreatic beta-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer. Autoimmunity 1994; 18: 285-90.
33. Seven A, Güzel S, Seymen O, Civelek S, Bolayirli M, Uncu M et al. Effects of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: investigation of liver and plasma. Yonsei Med J 2004; 45: 703-10.