Glomerular hyperfiltration and proteinuria in transfusion-independent patients with β-thalassemia intermedia

Nephron - Clinical Practice

Volumn 121, Issue 3-4, 2013, Pages

  Ziyadeh, Fuad N ^a   Musallam, Khaled M ^c   Mallat, Naji S ^a   Mallat, Samir ^a   Jaber, Fadel ^a   Mohamed, Ali Abdulnabi ^a   Koussa, Suzanne ^b   Taher, Ali T ^a,b  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b Chronic Care Center Hazmieh   (Lebanon)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Anemia; Glomerular filtration rate; Iron overload; Proteinuria; Thalassemia; Tubule cells

Indexed keywords

CREATININE; IRON; PROTEIN;

ADOLESCENT; ADULT; ANEMIA; ARTICLE; BETA THALASSEMIA; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; ERYTHROCYTE COUNT; FEMALE; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HEMOLYSIS; HUMAN; IRON OVERLOAD; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEINURIA; SCHOOL CHILD;

ADOLESCENT; ADULT; BETA-THALASSEMIA; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; IRON OVERLOAD; KIDNEY DISEASES; LEBANON; MALE; MIDDLE AGED; PREVALENCE; PROTEINURIA; RISK ASSESSMENT; YOUNG ADULT;

EID: 84870729584     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000339787     Document Type: Article

References (43)

1. Weatherall DJ: The inherited diseases of hemoglobin are an emerging global health burden. Blood 2010; 115: 4331-4336.
2. Steinberg MH, Forget BG, Higgs DR, Weatherall DJ: Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, ed 2. Cambridge, Cambridge University Press, 2009.
3. Taher AT, Musallam KM, Cappellini MD, Weatherall DJ: Optimal management of beta thalassaemia intermedia. Br J Haematol 2011; 152: 512-523.
4. Ponticelli C, Musallam KM, Cianciulli P, Cappellini MD: Renal complications in transfusion-dependent beta thalassaemia. Blood Rev 2010; 24: 239-244.
5. Quinn CT, Johnson VL, Kim HY, Trachtenberg F, Vogiatzi MG, Kwiatkowski JL, Neufeld EJ, Fung E, Oliveri N, Kirby M, Giardina PJ: Renal dysfunction in patients with thalassaemia. Br J Haematol 2011; 153: 111-117.
6. Smolkin V, Halevy R, Levin C, Mines M, Sakran W, Ilia K, Koren A: Renal function in children with beta-thalassemia major and thalassemia intermedia. Pediatr Nephrol 2008; 23: 1847-1851.
7. Ali D, Mehran K, Moghaddam AG: Comparative evaluation of renal findings in betathalassemia major and intermedia. Saudi J Kidney Dis Transpl 2008; 19: 206-209.
8. Camaschella C, Cappellini MD: Thalassemia intermedia. Haematologica 1995; 80: 58-68.
9. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R: Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005; 105: 855-861. (Pubitemid 40070775)
10. Taher A, Musallam KM, El Rassi F, Duca L, Inati A, Koussa S, Cappellini MD: Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia. Br J Haematol 2009; 146: 569-572.
11. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.
12. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL: New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009; 20: 629-637.
13. Schwartz GJ, Work DF: Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 2009; 4: 1832-1843.
14. Ficociello LH, Perkins BA, Roshan B, Weinberg JM, Aschengrau A, Warram JH, Krolewski AS: Renal hyperfiltration and the development of microalbuminuria in type 1 diabetes. Diabetes Care 2009; 32: 889-893.
15. Rees DC, Williams TN, Gladwin MT: Sicklecell disease. Lancet 2010; 376: 2018-2031.
16. Guasch A, Navarrete J, Nass K, Zayas CF: Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol 2006; 17: 2228-2235. (Pubitemid 44141913)
17. Koliakos G, Papachristou F, Koussi A, Perifanis V, Tsatra I, Souliou E, Athanasiou M: Urine biochemical markers of early renal dysfunction are associated with iron overload in beta-thalassaemia. Clin Lab Haematol 2003; 25: 105-109. (Pubitemid 36458159)
18. Michelakakis H, Dimitriou E, Georgakis H, Karabatsos F, Fragodimitri C, Saraphidou J, Premetis E, Karagiorga-Lagana M: Iron overload and urinary lysosomal enzyme levels in beta-thalassaemia major. Eur J Pediatr 1997; 156: 602-604. (Pubitemid 27351845)
19. Sadeghi-Bojd S, Hashemi M, Karimi M: Renal tubular function in patients with betathalassaemia major in Zahedan, southeast Iran. Singapore Med J 2008; 49: 410-412. (Pubitemid 351716712)
20. Zhou XJ, Laszik Z, Wang XQ, Silva FG, Vaziri ND: Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis. Lab Invest 2000; 80: 1905-1914. (Pubitemid 32012758)
21. Landing BH, Gonick HC, Nadorra RL, Hyman CB, Wells TR, Villarreal-Engelhardt G, Mersch J, Agness CL: Renal lesions and clinical findings in thalassemia major and other chronic anemias with hemosiderosis. Pediatr Pathol 1989; 9: 479-500. (Pubitemid 19262124)
22. Kassab-Chekir A, Laradi S, Ferchichi S, Haj Khelil A, Feki M, Amri F, Selmi H, Bejaoui M, Miled A: Oxidant, antioxidant status and metabolic data in patients with beta-thalassemia. Clin Chim Acta 2003; 338: 79-86. (Pubitemid 37456693)
23. King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King JC: Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp Biol Med (Maywood) 2008; 233: 701-707.
24. Kokoszko A, Dabrowski J, Lewinski A, Karbownik-Lewinska M: Protective effects of GH and IGF-I against iron-induced lipid peroxidation in vivo. Exp Toxicol Pathol 2008; 60: 453-458.
25. Zager RA, Johnson AC, Hanson SY: Parenteral iron nephrotoxicity: potential mechanisms and consequences. Kidney Int 2004; 66: 144-156. (Pubitemid 38870090)
26. Zager RA, Johnson AC, Hanson SY: Proximal tubular cytochrome c efflux: determinant, and potential marker, of mitochondrial injury. Kidney Int 2004; 65: 2123-2134. (Pubitemid 38669998)
27. Shah SV: Oxidants and iron in chronic kidney disease. Kidney Int Suppl 2004:S50-S55. (Pubitemid 39281715)
28. Sumboonnanonda A, Malasit P, Tanphaichitr VS, Ong-ajyooth S, Sunthornchart S, Pattanakitsakul S, Petrarat S, Assateerawatt A, Vongjirad A: Renal tubular function in beta-thalassemia. Pediatr Nephrol 1998; 12: 280-283.
29. Fibach E, Rachmilewitz E: The role of oxidative stress in hemolytic anemia. Curr Mol Med 2008; 8: 609-619.
30. Nagababu E, Gulyani S, Earley CJ, Cutler RG, Mattson MP, Rifkind JM: Iron-deficiency anaemia enhances red blood cell oxidative stress. Free Radic Res 2008; 42: 824-829.
31. Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW: The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol 1976; 31: 155-163.
32. Lindeman RD, Tobin J, Shock NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985; 33: 278-285. (Pubitemid 15087125)
33. Davis LE, Hohimer AR: Hemodynamics and organ blood flow in fetal sheep subjected to chronic anemia. Am J Physiol 1991; 261:R1542-R1548.
34. Lafferty HM, Anderson S, Brenner BM: Anemia: A potent modulator of renal hemodynamics in models of progressive renal disease. Am J Kidney Dis 1991; 17: 2-7.
35. Nangaku M: Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006; 17: 17-25.
36. Alfrey AC: Role of iron and oxygen radicals in the progression of chronic renal failure. Am J Kidney Dis 1994; 23: 183-187. (Pubitemid 24075308)
37. Taher AT, Musallam KM, Karimi M, El-Beshlawy A, Belhoul K, Daar S, Saned MS, El-Chafic AH, Fasulo MR, Cappellini MD: Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the optimal care study. Blood 2010; 115: 1886-1892.
38. Taher AT, Musallam KM, Karimi M, El-Beshlawy A, Belhoul K, Daar S, Saned M, Cesaretti C, Cappellini MD: Splenectomy and thrombosis: the case of thalassemia intermedia. J Thromb Haemost 2010; 8: 2152-2158.
39. Cappellini MD, Motta I, Musallam KM, Taher AT: Redefining thalassemia as a hypercoagulable state. Ann NY Acad Sci 2010; 1202: 231-236.
40. Haymann JP, Stankovic K, Levy P, Avellino V, Tharaux PL, Letavernier E, Grateau G, Baud L, Girot R, Lionnet F: Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature. Clin J Am Soc Nephrol 2010; 5: 756-761.
41. Schein A, Enriquez C, Coates TD, Wood JC: Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging 2008; 28: 698-704.
42. Tavazzi D, Duca L, Graziadei G, Comino A, Fiorelli G, Cappellini MD: Membranebound iron contributes to oxidative damage of beta-thalassaemia intermedia erythrocytes. Br J Haematol 2001; 112: 48-50. (Pubitemid 32151148)
43. Inoue T, Kozawa E, Okada H, Inukai K, Watanabe S, Kikuta T, Watanabe Y, Takenaka T, Katayama S, Tanaka J, Suzuki H: Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J Am Soc Nephrol 2011; 22: 1429-1434.