Magnetic resonance detection of kidney iron deposition in sickle cell disease: A marker of chronic hemolysis

Journal of Magnetic Resonance Imaging

Volumn 28, Issue 3, 2008, Pages 698-704

  Schein, Aaron ^a,b   Enriquez, Cathleen ^b   Coates, Thomas D ^b   Wood, John C ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Hemolysis; Iron; Kidney; Relaxometry; Sickle cell disease; Thalassemia

Indexed keywords

BIOLOGICAL MARKER; IRON; LACTATE DEHYDROGENASE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HEMOSIDEROSIS; HUMAN; INTRAVASCULAR HEMOLYSIS; IRON BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SICKLE CELL ANEMIA; THALASSEMIA MAJOR; UNIVARIATE ANALYSIS;

ADOLESCENT; ALGORITHMS; ANEMIA, HEMOLYTIC; ANEMIA, SICKLE CELL; BIOLOGICAL MARKERS; CHRONIC DISEASE; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IRON; IRON OVERLOAD; KIDNEY; MAGNETIC RESONANCE IMAGING; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 51449096407     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.21490     Document Type: Article

References (44)

1. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann N Y Acad Sci 1998;850:251-269.
2. Gordeuk VR, Bacon BR, Brittenham GM. Iron overload: causes and consequences. Annu Rev Nutr 1987;7:485-508.
3. Brittenham GM, Badman DG. Noninvasive measurement of iron: report of an NIDDK workshop. Blood 2003;101:15-19.
4. Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005;106:1460-1465.
5. Ghugre NR, Enriquez CM, Gonzalez I, Nelson MD Jr, Coates TD, Wood JC. MRI detects myocardial iron in the human heart. Magn Reson Med 2006;56:681-686.
6. Ghugre N, Enriquez C, Wood JC. Myocardial R2 and R2* vary linearly with cardiac iron in human heart. In: Proc 13th Annual Meeting ISMRM, Miami Beach, FL; 2005.
7. Wood JC, Otto-Duessel M, Aguilar M, et al. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 2005;112:535-543.
8. Buckalew VM Jr, Someren A. Renal manifestations of sickle cell disease. Arch Intern Med 1974;133:660-669.
9. Lande IM, Glazer GM, Sarnaik S, Aisen A, Rucknagel D, Martel W. Sickle-cell nephropathy: MR imaging. Radiology 1986;158:379-383.
10. Solecki R, von Zglinicki T, Muller HM, Clausing P. Iron overload of spleen, liver and kidney as a consequence of hemolytic anaemia. Exp Pathol 1983;23:227-235.
11. Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J Am Soc Nephrol 2007;18:414-420.
12. Gburek J, Verroust PJ, Willnow TE, et al. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol 2002;13:423-430.
13. Jeong JY, Kim SH, Lee HJ, Sim JS. Atypical low-signal-intensity renal parenchyma: causes and patterns. Radiographics 2002;22:833-846.
14. Zhou XJ, Laszik Z, Wang XQ, Silva FG, Vaziri ND. Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis. Lab Invest 2000;80:1905-1914.
15. Bayazit AK, Noyan A, Aldudak B, et al. Renal function in children with sickle cell anemia. Clin Nephrol 2002;57:127-130.
16. Buhl L, Muirhead DE, Prentis PF. Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. Ultrastruct Pathol 1993;17:169-183.
17. Koliakos G, Papachristou F, Koussi A, et al. Urine biochemical markers of early renal dysfunction are associated with iron overload in beta-thalassaemia. Clin Lab Haematol 2003;25:105-109.
18. Michelakakis H, Dimitriou E, Georgakis H, et al. Iron overload and urinary lysosomal enzyme levels in beta-thalassaemia major. Eur J Pediatr 1997;156:602-604.
19. Ong-ajyooth L, Malasit P, Ong-ajyooth S, et al. Renal function in adult beta-thalassemia/Hb E disease. Nephron 1998;78:156-161.
20. Saborio P, Scheinman JI. Sickle cell nephropathy. J Am Soc Nephrol 1999;10:187-192.
21. Ghugre NR, Enriquez CM, Coates TD, Nelson MD Jr, Wood JC. Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging 2006;23:9-16.
22. Dinkel E, Ertel M, Dittrich M, Peters H, Berres M, Schulte-Wissermann H. Kidney size in childhood. Sonographical growth charts for kidney length and volume. Pediatr Radiol 1985;15:38-43.
23. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-761.
24. Angelucci E, Brittenham GM, McLaren CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 2000;343:327-331.
25. Kato GJ, McGowan V, Machado RF, et al. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 2006;107:2279-2285.
26. Morris CR, Kato GJ, Poljakovic M, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA 2005;294:81-90.
27. Nasr SH, Markowitz GS, Sentman RL, D'Agati VD. Sickle cell disease, nephrotic syndrome, and renal failure. Kidney Int 2006;69:1276-1280.
28. Lee JW, Kim SH, Yoon CJ. Hemosiderin deposition on the renal cortex by mechanical hemolysis due to malfunctioning prosthetic cardiac valve: report of MR findings in two cases. J Comput Assist Tomogr 1999;23:445-447.
29. Suzukawa K, Ninomiya H, Mitsuhashi S, Anno I, Nagasawa T, Abe T. Demonstration of the deposition of hemosiderin in the kidneys of patients with paroxysmal nocturnal hemoglobinuria by magnetic resonance imaging. Intern Med 1993;32:686-690.
30. Kumpers P, Herrmann A, Lotz J, Mengel M, Schwarz A. A blue kidney - chronic renal failure as a consequence of siderosis in paroxysmal nocturnal hemoglobinuria? Clin Nephrol 2006;66:210-213.
31. Mathieu D, Rahmouni A, Villeneuve P, Anglade MC, Rochant H, Vasile N. Impact of magnetic resonance imaging on the diagnosis of abdominal complications of paroxysmal nocturnal hemoglobinuria. Blood 1995;85:3283-3288.
32. Roubidoux MA. MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria. Abdom Imaging 1994;19:168-173.
33. Siegelman ES, Mitchell DG, Semelka RC. Abdominal iron deposition: metabolism, MR findings, and clinical importance. Radiology 1996;199:13-22.
34. Siegelman ES, Outwater E, Hanau CA, et al. Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr 1994;18:63-67.
35. Lezcano NE, Odo N, Kutlar A, Brambilla D, Adams RJ. Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke. Stroke 2006;37:1424-1426.
36. Chalevelakis G, Clegg JB, Weatherall DJ. Imbalanced globin chain synthesis in heterozygous beta-thalassemic bone marrow. Proc Natl Acad Sci U S A 1975;72:3853-3857.
37. Aldudak B, Karabay Bayazit A, Noyan A, et al. Renal function in pediatric patients with beta-thalassemia major. Pediatr Nephrol 2000;15:109-112.
38. Voskaridou E, Terpos E, Michail S, et al. Early markers of renal dysfunction in patients with sickle cell/beta-thalassemia. Kidney Int 2006;69:2037-2042.
39. Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004;350:886-895.
40. Powars DR, Chan LS, Hiti A, Ramicone E, Johnson C. Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients. Medicine (Baltimore) 2005;84:363-376.
41. Clark DA, Butler SA, Braren V, Hartmann RC, Jenkins DE Jr. The kidneys in paroxysmal nocturnal hemoglobinuria. Blood 1981;57:83-89.
42. Sadowski EA, Fain SB, Alford SK, et al. Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience. Radiology 2005;236:911-919.
43. Prasad PV, Edelman RR, Epstein FH. Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 1996;94:3271-3275.
44. Ghugre N, Enriquez C, Coates TD, Nelson MD, Wood JC. Improved R2* measurements in myocardial iron overload. J Cardiovasc Magn Reson 2005;7:32-33.