Urine biochemical markers of early renal dysfunction are associated with iron overload in β-thalassaemia

Clinical and Laboratory Haematology

Volumn 25, Issue 2, 2003, Pages 105-109

  Koliakos, George ^a   Papachristou, F ^b   Koussi, A ^b   Perifanis, V ^b   Tsatra, I ^b   Souliou, E ^c   Athanasiou, M ^b  

^a Department of Biological Chemistry ^*  (Greece)

^b 1st Department of Paediatrics   (Greece)

^c ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

Author keywords

thalassemia; Desferioxamine; Iron overload; Tubular dysfunction; Urine makers

Indexed keywords

ALBUMIN; BETA 2 MICROGLOBULIN; BIOCHEMICAL MARKER; DEFEROXAMINE; FERRITIN; IRON; N ACETYL BETA GLUCOSAMINIDASE;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BETA THALASSEMIA; CHEMICAL ANALYSIS; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FERRITIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IRON OVERLOAD; KIDNEY DYSFUNCTION; LIVER BIOPSY; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT OUTCOME; URINALYSIS; URINE LEVEL;

ACETYLGLUCOSAMINIDASE; ADOLESCENT; ADULT; AGED; ALBUMINURIA; BETA 2-MICROGLOBULIN; BETA-THALASSEMIA; BIOLOGICAL MARKERS; BIOPSY; BLOOD TRANSFUSION; CHELATION THERAPY; CHILD; CHILD, PRESCHOOL; DEFEROXAMINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FERRITINS; GREECE; HEMOGLOBINS; HOMOZYGOTE; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G; IRON CHELATING AGENTS; IRON OVERLOAD; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; LIVER; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY;

EID: 0037394673     PISSN: 01419854     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2257.2003.00507.x     Document Type: Article

References (24)

1. Aldudak B., Karabay Bayazit A., Noyan A., Ozel A., Anarat A., Sasmaz I., Kiline Y., Gali E., Anarat R. & Dikmen N. (2000) Renal function in pediatric patients with beta-thalassemia major. Pediatric Nephrology 15, 109-112.
2. Bianchi-Bosisio A., D'Agrosa F., Gaboardi F., Gianazza E. & Righetti P.G. (1991) Sodium dodecyl sulphate electrophoresis of urinary proteins. J Chromatography 569, 243-260.
3. Cassimos Chr., Aivazis V., Karamperis G. & Katsouyannopoulos V. (1982) Arterial blood pressure, serum lipids and cardiovascular complications in families of hypertensive children. Acta Paediatricia Scandinavica 71, 235-238.
4. Cianciulli P., Sollecito D., Sorrentino F., Forte L., Gilardi E., Massa A., Papa G. & Carta S. (1994) Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy. Kidney International. 46, 467-470.
5. Dimitriou E., Kairis M., Sarafidou J. & Michelakis H. (2000) Iron overload and kidney lysosomes. Biochim Biophysica Acta 1501, 138-148.
6. Heukeshoven J. & Dernic R. (1985) Simplified method for silver staining of proteins in polyacrylamide gels and the mechanism of silver staining. Electrophoresis 6, 103-112.
7. Kattamis C., Karambula K., Metaxotou-Maauromati A., Ladis V. & Constantopoulos A. (1978) Prevalence of β 0 and β+ thalassemia genes in Greek children with homozygous β thalassemia. Hemoglobin 2, 29-32.
8. Koliakos G., Papachristou F., Papadopoulou M., Trachana V., Gaitatzi M. & Sotiriou I. (2001) Electrophoretic analysis of urinary proteins in diabetic adolescents. Jounal of Clinical and Laboratory Analysis 2, 178-183.
9. Koren G., Bentur Y., Strong D., Harvey E., Klein J., Baumal R., Spielberg SP. & Freedman M.H. (1989) Acute changes in renal function associated with deferoxamine therapy. American Journal of Diseases of Children 143, 1077-1080.
10. Koren G., Kochavi-Atiya Y., Bentur Y. & Olivieri N.F. (1991) The effects of subcutaneous deferoxamine administration on renal function in thalassemia major. International Journal of Hematology 54, 371-375.
11. Landing B.H., Gonick H.C., Nadorra R.L., Hyman C.B., Wells T.R., Villarreal-Engelhardt G., Mersch J. & Agness C.L. (1989) Renal lesions and clinical findings in thalassemia major and other chronic anemias with hemosiderosis. Pediatrics and Pathology 9, 479-500.
12. Lau Y.K. & Woo K.T. (2002) SDS-PAGE is underutilized as a tool for investigating renal patients. Nephron 90, 227-229.
13. Loebstein R., Lehotay D.C., Luo X., Bartfay W., Tyler B. & Sher G.D. (1998) Diabetic nephropathy in hypertransfused patients with beta-thalassemia. The role of oxidative stress. Diabetes Care 21, 1306-1309.
14. Mastrangelo F., Lopez T., Rizzelli S., Manisco G., Corliano C. & Alfonso L. (1975) Function of the kidney in adult patients with Cooley's disease. A preliminary report. Nephron 143, 229-236.
15. Mediterranean Committee for Thalassemia (1985) A short guide to the management of thalassemia. In: Thalassemia Today. eds. C. Sirchia & A. Zanella 2nd Mediteranean Meeting on Thalassemia. Centro Transfusionale Ospetale Maggiore Polyclinico di Milano, Milano, Italy, pp. 635-663.
16. Michelakakis H., Dimitriou E., Georakis H., Karabatsos F., Fragodimitri C., Saraphidou J., Premetis E. & Karagiorga-Lagana M. (1997) Iron overload and urinary lysosomal enzyme levels in beta-thalassaemia major. European Journal of Pediatrics 156, 602-604.
17. Modell B., Khan M. & Darlison M. (2000) Survival in β thalassemia major in the UK: data from the UK Thalassemia Register. Lancet 355, 2051-2052.
18. Ong-ajyooth L., Malasit P., Ong-ajyooth S., Fucharoen S., Pootrakul P., Vasuattakul S., Siritanaratkul N. & Nilwarangkur S. (1998) Renal function in adult beta-thalassemia/Hb E disease. Nephron 78, 156-161.
19. Papakonstantinou O., Kostaridou S., Maris T., Gouliamos A., Premetis E., Kouloulias V., Nakopoulou L. & Kattamis C. (1999) Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. Journal of Pediatric Hematology/Oncology 21, 142-148.
20. Schiwara H.W., Hebell T., Kirchherr H., Postel W., Weser J. & Gorg A. (1986) Ultrathin-layer sodium dodecyl sulfate-polyacrylamide gradient gel electrophoresis and silver staining of urinary proteins. Electrophoresis 7, 496-505.
21. Schwartz G.J., Haycock G.B., Edelmann C.M. & Spitzer A. (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58, 259-263.
22. Skrha J. & Hilgertova J. (1999) Relationship of serum N-acetyl-beta-glucosaminidase activity to oxidative stress in diabetic mellitus. Clinical Chimica 282, 167-174.
23. Sumboonnanonda A., Malasit P., Tanphaichitr V.S., Ong-ajyooth S., Sunthornchart S., Pattanakitsakul S., Petrarat S., Assateerawatt A. & Vongjirad A. (1998) Renal tubular function in β-thalassemia. Pediatric Nephrology 12, 280-283.
24. Tucker S.M., Boyd P.J.R., Thompson A.E. & Price R.G. (1975) Automated assay of N Acetyl-β-Glycosaminidase in normal and pathological human urine. Clinica Chimica Acta 62, 333-339.