Membrane-bound iron contributes to oxidative damage of β-thalassaemia intermedia erythrocytes

British Journal of Haematology

Volumn 112, Issue 1, 2001, Pages 48-50

  Tavazzi, Dario ^a   Duca, Lorena ^a   Graziadei, Giovanna ^a   Comino, Alessia ^a   Fiorelli, Gemino ^a   Cappellini, Maria Domenica ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Erythrocyte membrane; Iron; Oxidative stress; Thalassaemia

Indexed keywords

IRON;

ADULT; ARTICLE; BETA THALASSEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE MEMBRANE; FEMALE; HUMAN; IRON BLOOD LEVEL; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; SPLENECTOMY;

ADULT; BETA-THALASSEMIA; CASE-CONTROL STUDIES; CELL DEATH; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; HUMANS; IRON; MALE; OXIDATIVE STRESS; SPLENECTOMY; STATISTICS, NONPARAMETRIC;

EID: 0035134808     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02482.x     Document Type: Article

References (12)

1. The molecular pathobiology of cell membrane iron: The sickle red cell as a model
2. Metabolic indicators of oxidative stress correlate with haemichrome attachment to membrane, band 3 aggregation and erythrophagocytosis in β-thalassaemia intermedia erythrocytes
3. Deferiprone therapy in homozygous human β-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity
4. Nonheme iron in sickle erythrocyte membranes: Association with phospholipids and potential role in lipid peroxidation
5. Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-ortophtalaldehyde adduct
6. Kinetics of removal and reappearance of non-transferrin - Bound plasma iron with deferoxamine therapy
7. Hydroxyl radical formation by sickle erythrocyte membranes: Role of pathologic iron deposits and cytoplasmic reducing agents
8. Nonrandom association of free iron with membranes of sickle and β-thalassemic erythrocytes
9. Thalassaemic erythrocytes: Cellular suicide arising from iron and glutathione-dependent oxidation reactions?
10. Effects of excess α-hemoglobin chains on cellular and membrane oxidation in model β-thalassemic erythrocytes
11. Catalysis of soluble hemoglobin oxidation by free iron on sickle red cell membranes
12. Indices of membrane alterations in β-thalassemic erythrocytes