Peripheral nerve damage in patients with leprosy;Neuropathies au cours de la lèpre

Revue Neurologique

Volumn 168, Issue 12, 2012, Pages 967-974

  Grimaud, J ^a  

^a Hopital Louis Pasteur   (France)

Author keywords

Leprosy; Mycobacterium leprae; Nerve

Indexed keywords

ARTICLE; DIFFERENTIAL DIAGNOSIS; ENDEMIC DISEASE; HUMAN; IMMUNE RESPONSE; LEPROSY; NEUROLOGIST; PERIPHERAL NERVE INJURY; SKIN DEFECT; STIGMA;

EID: 84870721835     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2012.05.017     Document Type: Review

References (133)

1. N.H. Antia, and N. Kamala Persistence of M. leprae in peripheral nerve Indian J Med Res 77 1983 420 422
2. N.H. Antia, and N.J. Pandya Qualitative histology and quantitative bacteriology in various tissues of 50 leprosy patients Lepr Rev 47 1976 175 183
3. S.L. Antunes, M.F. Medeiros, S. Corte-Real, M.R. Jardim, J.A. Nery, and M.A. Hacker Microfasciculation: a morphological pattern in leprosy nerve damage Histopathology 58 2011 304 311
4. M.V. Balagon, R.H. Gelber, R.M. Abalos, and R.V. Cellona Reactions following completion of 1 and 2 year multidrug therapy (MDT) Am J Trop Med Hyg 83 2010 637 644
5. M.D. Batista, A.M. Porro, S.M. Maeda, E.E. Gomes, M.C. Yoshioka, and M.M. Enokihara Leprosy reversal reaction as immune reconstitution inflammatory syndrome in patients with AIDS Clin Infect Dis 46 2008 e56 e60
6. E.H. Bernink, and J.E. Voskens Study on the detection of leprosy reactions and the effect of prednisone on various nerves, Indonesia Lepr Rev 68 1997 225 232
7. M. Becx-Bleumink Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia: practical difficulties with diagnosis relapses; operational procedures and criteria for diagnosing relapses Int J Lepr Other Mycobact Dis 60 1992 421 435
8. N. Boku, D.N. Lockwood, M.V. Balagon, F.E. Pardillo, A.A. Maghanoy, and I.B. Mallari Impacts of the diagnosis of leprosy and of visible impairments amongst people affected by leprosy in Cebu, the Philippines Lepr Rev 81 2010 111 120
9. P. Boucher, J. Millan, M. Parent, and J.P. Moulia-Pela Essai comparé randomisé du traitement médical et médico-chirurgical des névrites hanséniennes Acta Leprol 11 1999 171 177
10. J.R.C. Bowen, A.C. McDougall, J.H. Morris, S.B. Lucas, and M. Donaghy Vasculitic neuropathy in a patient with inactive treated lepromatous leprosy J Neurol Neurosurg Psychiatry 68 2000 496 500
11. W.J. Britton The management of leprosy reversal reactions Leprosy Rev 69 1998 225 234
12. R. Bwire, and H.J. Kawuma Type 1 reactions in leprosy, neuritis and steroid therapy: the impact of the human immunodeficiency virus Trans R Soc Trop Med Hyg 88 1994 315 316
13. G.D. Capadia, V.P. Shetty, F.A. Khambati, and S.D. Ghate Effect of corticosteroid usage combined with multidrug therapy on nerve damage assessed using nerve conduction studies: a prospective cohort study of 365 untreated multibacillary leprosy patients J Clin Neurophysiol 27 2010 38 47
14. G.T. Chae, M.J. Kim, T.J. Kang, S.B. Lee, H.K. Shin, and J.P. Kim DNA-PCR and RT-PCR for the 18-kDa gene of Mycobacterium leprae to assess the efficacy of multi-drug therapy for leprosy J Med Microbiol 51 2002 417 422
15. F. Chaise La prise en charge actuelle des mains lépreuses Chir Main 23 2004 1 16
16. K. Chamoto, T. Takeshima, A. Kosaka, T. Tsuji, J. Matsuzaki, and Y. Togashi NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by alpha-galactosylceramide in vivo Immunol Lett 95 2004 5 11
17. P. Chemouilli, S. Woods, G. Said, and S.T. Cole Detection of Mycobacterium leprae in nerve lesions by the polymerase chain reaction Int J Lepr Other Mycobact Dis 64 1996 1 5
18. S.N. Cho, B.J. Gormus, K. Xu, R.P. Bohm Jr., G.P. Walsh, and W.M. Meyers Serologic responses to nerve antigens in sooty mangabey monkeys with experimental leprosy Int J Lepr Other Mycobact Dis 61 1993 236 244
19. P. Couppié, S. Abel, H. Voinchet, M. Roussel, R. Hélénon, and M. Huerre Immune reconstitution inflammatory syndrome associated with HIV and leprosy Arch Dermatol 140 2004 997 1000
20. R.P. Croft, P.G. Nicholls, J.H. Richardus, and W.C. Smith Incidence rates of acute nerve function impairment in leprosy: a prospective cohort analysis after 24 months (The Bangladesh Acute Nerve Damage Study) Lepr Rev 71 2000 18 33
21. R.P. Croft, P.G. Nicholls, E.W. Steyerberg, J.H. Richardus, W. Cairns, and S. Smith A clinical prediction rule for nerve-function impairment in leprosy patients Lancet 355 2000 1603 1606 [Lettre aux auteurs et réponse: Lancet 2000;356;1767]
22. R.P. Croft, J.H. Richardus, P.G. Nicholls, and W.C. Smith Nerve function impairment in leprosy: design, methodology, and intake status of a prospective cohort study of 2664 new leprosy cases in Bangladesh (The Bangladesh Acute Nerve Damage Study) Lepr Rev 70 1999 140 159
23. R. Croft, J.H. Richardus, and W.C. Smith The effectiveness of corticosteroids in the treatment of long-term nerve function impairment Lepr Rev 67 1996 342 343
24. P. Deps, and D.N. Lockwood Leprosy presenting as immune reconstitution inflammatory syndrome: proposed definitions and classification Lepr Rev 81 2010 59 68
25. A.J. de Rijk, S. Gabre, P. Byass, and T. Berhanu Field evaluation of WHO-MDT of fixed duration at ALERT, Ethiopia: the AMFES project - II. Reaction and neuritis during and after MDT in PB and MB leprosy patients Lepr Rev 65 1994 320 332
26. K.V. Desikan Comment on "A high incidence of viable Mycobacterium leprae in post-MDT recurrent lesions in tuberculoid leprosy patients" by Shetty et al Lepr Rev 73 2002 282
27. G. Discamps, A. Chevallard, P. Bobin, J. Grimaud, L. Blum, and J. Millan Analyse histologique comparative des biopsies cutanées et du nerf périphérique dans la maladie de Hansen Acta Leprol 8 1992 43 45
28. M. Ebenezer, P. Andrews, and S. Solomon Comparative trial of steroids and surgical intervention in the management of ulnar neuritis Int J Lepr Other Mycobacter Dis 64 1996 282 286
29. J.A. Garbino, C. Virmond Mda, S. Ura, M.H. Salgado, and B. Naafs A randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactions Arq Neuropsiquiatr 66 2008 861 867
30. S. Gebre, P. Saunderson, and P. Byass Relapses after fixed duration multiple drug therapy: the AMFES cohort Lepr Rev 71 2000 325 331
31. E. Gibbels, F. Behse, G. Klingmüller, U. Henke-Lübke, W.F. Haupt, and E. Gollmer Sural nerve biopsy findings in leprosy: a qualitative and quantitative light and electron microscope study in 4 treated cases of the lepromatous spectrum Clin Neuropathol 7 1988 120 130
32. J. Grimaud, F. Chapuis, B. Verchot, and J. Millan Comment dépister la neuropathie hansénienne Rev Neurol 150 1994 785 790
33. G. Groenen, L. Janssens, T. Kayembe, E. Nollet, L. Coussens, and S.R. Pattyn Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions Int J Lepr Other Mycobacter Dis 54 1986 236 244
34. K. Hashimoto, Y. Maeda, H. Kimura, K. Suzuki, A. Masuda, and M. Matsuoka Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function Infect Immun 70 2002 5167 5176
35. S. Husain, B. Mishra, V. Prakash, and G.N. Malaviya Evaluation of results of surgical decompression of median nerve in leprosy in relation to sensory - motor functions Acta Leprol 10 1997 199 201
36. M. Jacob, and R. Mathai Diagnostic efficacy of cutaneous nerve biopsy in primary neuritic leprosy Int J Lepr Other Mycobact Dis 56 1988 56 60
37. J.M. Jacobs, V.P. Shetty, and N.H. Antia A morphological study of nerve biopsies from cases of multibacillary leprosy given multidrug therapy Acta Neuropathol (Berl) 85 1993 533 541
38. R.S. Jadhav, M. MacDonald, G. Bjune, and L. Oskam Simplified PCR detection method for nasal Mycobacterium leprae Int J Lepr Other Mycobact Dis 69 2001 299 307
39. R. Jadhav, L. Suneetha, R. Kamble, V. Shinde, K. Devi, and M.V. Chaduvula Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India PLoS Negl Trop Dis 5 2011 e977
40. M.R. Jardim, S.L. Antunes, A.R. Santos, O.J. Nascimento, J.A. Nery, and A.M. Sales Criteria for diagnosis of pure neural leprosy J Neurol 250 2003 806 809
41. E. Jayaseelan, S. Shariff, and P. Rout Cytodiagnosis of primary neuritic leprosy Int J Lepr Other Mycobact Dis 77 1999 429 434
42. H. Kajihara, I.A. Paturusi, R.M. Saleh, C. Rasyad, and Y. Ikuta Light and electron microscopic study of peripheral nerve damage in patients with lepromatous lerposy (LL) and borderline lepromatous leprosy (BL) Hiroshima J Med Sci 49 2000 83 92
43. S. Kaur, V.K. Sharma, P. Basak, I. Kaur, and B.D. Radotra Concurrent skin and nerve histology in leprosy and its role in the classification of leprosy Lepr Rev 64 1993 110 116
44. H.J. Kawuma, R. Bwire, and F. Adatu-Engwau Leprosy and infection with the human immunodeficiency virus in Uganda: a case-control study Int J Lepr Other Mycobact Dis 62 1994 521 526
45. R. Kazen Role of surgery of nerves in leprosy in the restoration of sensibility in hands and feet of leprosy patients Indian J Lepr 68 1996 55 65
46. V. Kharkar, U.H. Bhor, S. Mahajan, and U. Khopkar Type I lepra reaction presenting as immune reconstitution inflammatory syndrome Indian J Dermatol Venereol Leprol 73 2007 253 256 [Comment in: Indian J Dermatol Venereol Leprol 2008;74:265-6]
47. J.D. Kim, S.N. Cho, S. Park, and G.P. Walsh Detection of antibodies to nerve antigens in a sera from leprosy patients and relevance to the nerve damage Korean J Immunol 19 1997 463 470
48. K. Kumar Surgical management of leprous ulnar neuritis Clin Orthop Relat Res 163 1982 235 242
49. S. Kumar, M.K. Ghosh, S. Sarkar, S. Mallik, P.N. Biswas, and B. Saha Tuberculoid leprosy and cytomegalovirus retinitis as immune restoration disease in a patient with AIDS Int J Infect Dis 16 2 2012 e146 e148
50. B. Kumar, and A. Pradhan Fine needle aspiration cytology in diagnosis of pure neuritic leprosy Patholog Res Int 2011 2011 158712
51. S.K.A. Kumar, B.S.N. Reddy, and C. Ratnakar Correlation of skin and nerve histopathology in leprosy Lepr Rev 67 1996 119 125
52. M. Kurabachew, A. Wondimu, and J.J. Ryon Reverse transcription-PCR detection of Mycobacterium leprae in clinical specimens J Clin Microbiol 36 1998 1352 1356
53. S.D. Lawn, and D.N. Lockwood Leprosy after starting antiretroviral treatment BMJ 334 2007 217 218
54. D.N. Lockwood, S. Vinayakumar, J.N. Stanley, K.P. McAdam, and M.J. Colston Clinical features and outcome of reversal (type 1) reactions in Hyderabad, India Int J Lepr Other Mycobact Dis 61 1993 8 15
55. D.N.J. Lockwood The management of erythema nodosum leprosum: current and future options Lepr Rev 67 1996 253 259
56. P.M. Mahajan, D.G. Jogaikar, and J.M. Mehta A study of pure neuritic leprtosy: clinical experience Indian J Lepr 68 1996 137 141
57. G.N. Malaviya, and G. Ramu Role of surgical decompression in ulnar neuritis of leprosy Lepr India 54 1982 287 302
58. K.A. Mattos, F.A. Lara, V.G. Oliveira, L.S. Rodrigues, H. D'Avila, and R.C. Melo Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes Cell Microbiol 13 2011 259 273
59. A. Meima, P.R. Saunderson, S. Gebre, K. Desta, and J.D. Habbema Dynamics of impairment during and after treatment: the AMFES cohort Lepr Rev 72 2001 158 170
60. L.A. Menicucci, A. Miranda, S.L. Antunes, M.R. Jardim, J.A. da Costa Nery, and A.M. Sales Microscopic leprosy skin lesions in primary neuritic leprosy J Am Acad Dermatol 52 2005 648 652
61. N.F. Mistry, and N.H. Antia Incomplete killing of intracellular mycobacteria - speculations on the creation of persisters Indian J Lepr 71 1999 69 74
62. C. Moschioni, C.M. Antunes, M.A. Grossi, and J.R. Lambertucci Risk factors for physical disability at diagnosis of 19,283 new cases of leprosy Rev Soc Bras Med Trop 43 2010 19 22
63. B. Naafs Treatment duration of reversal reaction: a reappraisal. Back to the past Lepr Rev 74 2003 328 336
64. V. Ng, G. Zanazzi, R. Timpl, J.F. Talts, J.L. Salzer, and P.J. Brennan Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae Cell 103 2000 511 524
65. R. Nielsen, G. Mengistu, and B.B. Reddy The role of nerve biopsies in the diagnosis and management of leprosy Lepr Rev 60 1989 28 32
66. R.B. Oliveira, M.T. Ochoa, P.A. Sieling, T.H. Rea, A. Rambukkana, and E.N. Sarno Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy Infect Immun 71 2003 1427 1433
67. D.D. Palande The promise of surgery, its scope and limitations in leprosy Lepr Rev 69 1998 168 172
68. J. Pavie, N. De Castro, J.M. Molina, and B. Flageul Severe peripheral neuropathy following HAART initiation in an HIV-infected patient with leprosy J Int Assoc Physicians AIDS Care (Chic Ill) 9 2010 232 235
69. L. Pocaterra, S. Jain, R. Reddy, S. Muzaffarullah, O. Torres, and S. Suneetha Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India Am J Trop Med Hyg 74 2006 868 879
70. J.M. Ponnighaus, C. Lienhardt, S. Lucas, P.E.M. Fine, and J.A.C. Sterne Comparison of bacillary indexes in slit-skin smears, skin and nerve biopsies. A study from Malawi Int J Lepr Other Mycobact Dis 65 1997 211 216
71. A. Rambukkana Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteria Prog Neurobiol 91 2010 102 107
72. A. Rambukkana, J.L. Saltzer, P.D. Yurchenco, and E.I. Tuomanen Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha 2 chain Cell 88 1997 811 821
73. A. Rambukkana, H. Yamada, G. Zanazzi, T. Mathus, J.L. Salzer, and P.D. Yurchenco Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae Science 282 1998 2076 2079
74. A. Rambukkana, G. Zanazzi, N. Tapinos, and J.L. Salzer Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells Science 296 2002 927 931
75. P.S. Rao, D.S. Sugamaran, J. Richard, and W.C. Smith Multi-centre, double blind, randomized trial of three steroid regimens in the treatment of type-1 reactions in leprosy Lepr Rev 77 2006 25 33
76. V.T. Ribeiro-Resende, M.L. Ribeiro-Guimarães, R.M. Lemes, I.C. Nascimento, L. Alves, and R. Mendez-Otero Involvement of 9-O-Acetyl GD3 ganglioside in Mycobacterium leprae infection of Schwann cells J Biol Chem 285 2010 34086 34096
77. J.H. Richardus, K.M. Finlay, R.P. Croft, and W.C.S. Smith Nerve function impairment in leprosy at diagnosis and at completion of MDT: a retrospective cohort study of 786 patients in Bangladesh Lepr Rev 67 1996 297 305
78. J.H. Richardus, P.G. Nicholls, R.P. Croft, S.G. Withington, and W.C. Smith Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow-up Int J Epidemiol 33 2004 337 343
79. J.H. Richardus, S.G. Withington, A.M. Anderson, R.P. Croft, P.G. Nicholls, and W.H. Van Brakel Treatment with corticosteroids of long-standing nerve function impairment in leprosy: a randomized controlled trial (TRIPOD 3) Lepr Rev 74 2003 311 318
80. D.S. Ridley, and M.J. Ridley Classification of nerves is modified by the delayed recognition of Mycobacterium leprae Int J Lepr Other Mycobact Dis 54 1986 596 606
81. P.W. Roche, W.J. Theuvenet, J.W. Le Master, and C.R. Butlin Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone Int J Lepr Other Mycobact Dis 66 1998 340 347
82. P. Rose, and M.F. Waters Reversal reactions in leprosy and their management (Editorial) Lepr Rev 62 1991 113 121
83. P. Saunderson The epidemiology of reactions and nerve damage Lepr Rev 71 SUPPL 2000 S106 S110
84. P. Saunderson, S. Gebre, K. Desta, P. Byass, and D.N. Lockwood The pattern of leprosy-related neuropathy in the AMFES patients in Ethiopia: definitions, incidence, risk factors and outcome Lepr Rev 71 2000 285 308
85. P.R. Saunderson, S. Gebre, K. Desta, and P. Byass The ALERT MDT Field Evaluation Study (AMFS): a descriptive study of leprosy in Ethiopia. Patients, methods and baseline caracteristics Lepr Rev 71 2000 273 284
86. L.S. Schlesinger, and M.A. Horwitz Phenolic glycolipid-1 of Mycobacterium leprae binds complement component C3 in serum and mediates phagocytosis by human monocytes J Exp Med 174 1991 1031 1038
87. P.A. Schreuder The occurrence of reactions and impairments in leprosy: experience in the leprosy control program of three provinces in northeastern Thailand, 1987-1995 [correction of 1978-1995]. I. Overview of the study Int J Lepr Other Mycobact Dis 66 1998 149 158
88. P.A. Schreuder The occurrence of reactions and impairments in leprosy: experience in the leprosy control program of three provinces in northeastern Thailand, 1987-1995 [correction of 1978-1995]. II. Reactions Int J Lepr Other Mycobact Dis 66 1998 159 169
89. P.A. Schreuder The occurrence of reactions and impairments in leprosy: experience in the leprosy control program of three provinces in northeastern Thailand, 1987-1995 [correction of 1978-1995]. III. Neural and other impairments Int J Lepr Other Mycobact Dis 66 1998 170 181
90. A. Sharma, V.K. Sharma, A. Rajwanshi, A. Das, I. Kaur, and B. Kumar Presence of M. leprae in tissues in slit skin smear negative multibacillary (MB) patients after WHO-MBR Lepr Rev 70 1999 281 286
91. V.P. Shetty, F.A. Khambati, S.D. Ghate, G.D. Capadia, V.V. Pai, and R. Ganapati The effect of corticosteroids usage on bacterial killing, clearance and nerve damage in leprosy. Part 3 - Study of two comparable groups of 100 multibacillary (MB) patients each, treated with MDT + steroids vs. MDT alone, assessed at 6 months post-release from 12 months MDT Lepr Rev 81 2010 41 58
92. V.P. Shetty, L.N. Mehta, P.F. Irani, and N.H. Antia Study of the evolution of nerve damage in leprosy: part I - Lesions of the index branch of the radial cutaneous nerve in early leprosy Lepr Ind 52 1980 5 18
93. V.P. Shetty, L.N. Mehta, P.F. Irani, and N.H. Antia Study of the evolution of nerve damage in leprosy: part II - Observation on the index branch of the radial cutaneous nerve in contacts of leprosy Lepr Ind 52 1980 19 25
94. V.P. Shetty, K. Suchitra, M.W. Uplekar, and N.H. Antia Higher incidence of viable Mycobacterium leprae within the nerve as compared to skin among multibacillary leprosy patients released from multidrug therapy Lepr Rev 68 1997 131 138
95. V.P. Shetty, A. Wakade, and N.H. Antia A high incidence of viable Mycobacterium leprae in post-MDT recurrent lesions in tuberculoid leprosy patients Lepr Rev 72 2001 337 344
96. V.P. Shetty, A.V. Wakade, N.H. Antia, V.V. Pai, C.R. Revenker, and R. Ganapati Clinical, histopathological and bacteriological investigations in two cases of relapse following ROM treatment Lepr Rev 72 2001 83 87
97. Y. Shimoji, V. Ng, K. Matsumura, V.A. Fischetti, and A. Rambukkana A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve laminin-2 mediates Schwann cell invasion Proc Natl Acad Sci U S A 96 1999 9857 9862
98. N. Siddaraju, S.C. Sistla, N. Singh, F. Muniraj, Q. Chahwala, and D. Basu Pure neuritic leprosy with nerve abscess presenting as a cystic, soft tissue mass: report of a case diagnosed by fine needle aspiration cytology Diagn Cytopathol 37 2009 355 358
99. C.L. Silva, L.H. Faccioli, and N.T. Foss Suppression of human monocyte cytokine release by phenolic glycolipid-I of Mycobacterium leprae Int J Lepr Other Mycobact Dis 61 1993 107 108
100. A. Singal, S. Mehta, and D. Pandhi Immune reconstitution inflammatory syndrome in an HIV seropositive leprosy patient Lepr Rev 77 2006 76 80
101. K. Singh, B. Singh, and P.C. Ray Anti-ceramide antibodies in leprosy: marker for nerve damage? J Infect Dev Ctries 4 2010 378 381
102. N. Singh, A. Malik, V.K. Arora, and A. Bhatia Fine needle aspiration cytology of leprous neuritis Acta Cytol 47 2003 368 372
103. W.C. Smith, P.G. Nicholls, L. Das, P. Barkataki, S. Suneetha, and L. Suneetha Predicting neuropathy and reactions in leprosy at diagnosis and before incident events-results from the INFIR cohort study PLoS Negl Trop Dis 2003 e500
104. W.C.S. Smith, A.M. Anderson, S.G. Withington, W.H. van Brakel, R.P. Croft, and P.G. Nicholls Steroid prophylaxis for prevention of nerve function impairment in leprosy: randomised placebo controlled trial (TRIPOD 1) BMJ 238 2004 1459
105. H. Srinivasan, K.S. Rao, and C.G.S. Iyer Discrepancy in histopathological features of leprosy lesions in the skin and peripheral nerve. Report of a preliminary study Lepr India 54 1982 275 282
106. H. Srinivasan, K.S. Rao, and N. Shanmugam Steroid therapy in recent "quiet nerve paralysis" in leprosy. Report of a study of twenty-five patients Lepr India 54 1982 412 419
107. D.S. Sugumaran Steroid therapy for paralytic deformities in leprosy Int J Lepr Other Mycobact Dis 65 1997 337 344
108. S. Suneetha, S. Arunthathi, S. Chandi, N. Kurian, and C.J.G. Chacko Histological studies in primary neuritic leprosy: changes in the apparently normal skin Lepr Rev 69 1998 351 357
109. S. Suneetha, S. Arunthathi, A. Job, A. Date, N. Kurian, and C.J.G. Chacko Histological studies in primary neuritic leprosy: changes in the nasal mucosa Lepr Rev 69 1998 358 366
110. L.M. Suneetha, P.R. Satish, R.J. Korula, S.K. Suneetha, C.K. Job, and A.S. Balasubramanian Mycobacterium leprae binds to a 25-kDa phosphorylated glycoprotein of human peripheral nerve Neurochem Res 23 1998 907 911
111. S. Suneetha, S. Arunthathi, N. Kurian, and C.J.G. Chacko Histological changes in the nerve, skin and nasal mucosa of patients with primary neuritic leprosy Acta Leprol 12 2000/2001 11 18
112. S. Suneetha, A. Sigamoni, N. Kurian, and C.J. Chacko The development of cutaneous lesions during follow-up of patients with primary neuritic leprosy Int J Dermatol 44 2005 224 229
113. C. Talhari, P.R. Machado, L.C. Ferreira, and S. Talhari Shifting of the clinical spectrum of leprosy in an HIV-positive patient: a manifestation of immune reconstitution inflammatory syndrome? Lepr Rev 78 2007 151 154
114. N. Tapinos, M. Ohnishi, and A. Rambukkana ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli Nat Med 12 2006 961 966
115. R.M. Teles, S.R. Krutzik, M.T. Ochoa, R.B. Oliveira, E.N. Sarno, and R.L. Modlin Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy Infect Immun 78 2010 4634 4643
116. A.K. Thacker, S. Chandra, R.D. Mukhija, and N.B.S. Sarkari Electro-physiological evaluation of nerves during reactions in leprosy J Neurol 243 1996 530 535
117. M.A. Trindade, M.I. Manini, J.H. Masetti, M.A. Leite, M.D. Takahashi, and B. Naafs Leprosy and HIV co-infection in five patients Lepr Rev 76 2005 162 166
118. M.W. Uplekar, and N.H. Antia Clinical and histopathological observations on pure neuritic leprosy Indian J Lepr 58 1986 513 521
119. A.P. Ustianowski, S.D. Lawn, and D.N. Lockwood Interactions between HIV infection and leprosy: a paradox Lancet Infect Dis 6 2006 350 360
120. J.M. Vallat, M.J. Leboutet, P. Henry, J. Millan, and M. Dumas Endoneurial proliferation of perineurial cells in leprosy Acta Neuropathol 81 1991 336 338
121. W.H. van Brakel, A.M. Anderson, S.G. Withington, R.P. Croft, P.G. Nicholls, and J.H. Richardus The prognostic importance of detecting mild sensory impairment in leprosy: a randomized controlled trial (TRIPOD 2) Lepr Rev 74 2003 300 310
122. W.H. van Brakel, I.B. Khawas, and S.B. Lucas Reactions in leprosy: an epidemiological study of 386 patients in west Nepal Lepr Rev 65 1994 190 203
123. W.H. van Brakel, and I.B. Khawas Silent neuropathy in leprosy: an epidemiological description Int J Lepr Other Mycobact Dis 65 1994 350 360
124. W.H. van Brakel, P.G. Nicholls, L. Das, P. Barkataki, P. Maddali, and D.N. Lockwood The INFIR Cohort Study: assessment of sensory and motor neuropathy in leprosy at baseline Lepr Rev 76 2005 277 295
125. N.H. van Veen, D.N. Lockwood, W.H. Van Brakel, J. Ramirez Jr., and J.H. Richardus Interventions for erythema nodosum leprosum. A Cochrane review Lepr Rev 80 2009 355 372
126. N.H. van Veen, T.A. Schreuders, W.J. Theuvenet, A. Agrawal, and J.H. Richardus Decompressive surgery for treating nerve damage in leprosy. A Cochrane review Lepr Rev 80 2009 3 12
127. N.H. van Veen, P.G. Nicholls, W.C. Smith, and J.H. Richardus Corticosteroids for treating nerve damage in leprosy. A Cochrane review Lepr Rev 79 2008 361 371
128. M. Vijaikumar, M. D'Souza, S. Kumar, and B. Badhe Fine needle aspiration cytology (FNAC) of nerves in leprosy Lepr Rev 72 2001 171 178
129. P. Vijayakumaran, N. Manimozhi, and K. Jesudasan Incidence of late lepra reaction among multibacillary leprosy patients after MDT Int J Lepr Other Mycobact Dis 63 1995 18 22
130. S.L. Walker, and D.N. Lockwood Leprosy type 1 (reversal) reactions and their management Lepr Rev 79 2008 372 386
131. S.L. Walker, P.G. Nicholls, S. Dhakal, R.A. Hawksworth, M. Macdonald, and K. Mahat A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment PLoS Negl Trop Dis 5 2011 e1041
132. A. Wilder-Smith, and E. Wilder-Smith Effect of steroid therapy on parameters of peripheral autonomic dysfunction in leprosy patients with acute neuritis Int J Lepr Other Mycobact Dis 65 1997 20 27
133. D.L. Williams, T.L. Pittman, T.P. Gillis, M. Matsuoka, and Y. Kashiwabara Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis J Clin Microbiol 39 2001 2083 2088