Predicting neuropathy and reactions in leprosy at diagnosis and before incident events - Results from the INFIR cohort study

PLoS Neglected Tropical Diseases

Volumn 3, Issue 8, 2009, Pages

  Smith, W Cairns S ^a   Nicholls, Peter G ^b   Das, Loretta ^c   Barkataki, Pramila ^d   Suneetha, Sujai ^e   Suneetha, Lavanya ^e   Jadhav, Rupendra ^f   Sundar Rao, P S S ^g   Wilder Smith, Einar P ^h   Lockwood, Diana N J ⁱ   Van Brakel, Wim H ^j  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c Naini Community Hospital   (India)

^d Leprosy Mission Hospital Faizabad   (India)

^e LEPRA Society   (India)

^f Stanley Browne Laboratory   (India)

^g India   (India)

^h NATIONAL UNIVERSITY HOSPITAL   (Singapore)

ⁱ LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^j ROYAL TROPICAL INSTITUTE   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL ASSESSMENT; COHORT ANALYSIS; DISABILITY; FEMALE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR NERVE CONDUCTION; MULTIBACILLARY LEPROSY; NERVE FUNCTION; NERVE INJURY; NEUROLOGIC EXAMINATION; NEUROPATHY; PREDICTION; SENSORY NERVE CONDUCTION; SEROLOGY; TEMPERATURE SENSITIVITY;

EID: 70449511212     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000500     Document Type: Article

References (19)

1. Saunderson PR, Gebre S, Dsta K, Byass P, Lockwood DN (2000) The pattern of leprosy related neuropathy in the AMFES patients in Ethiopia: definitions, incidence, risk factors and outcome. Lepr Rev 71: 285-308. (Pubitemid 30845913)
2. Schreuder PA (1998) The occurrence of reactions and impairments in leprosy: experience in he leprosy control program of three provinces in north eastern Thailand, 1978-1995. Int J Lepr 66: 170-181. (Pubitemid 28520359)
3. Richardus JH, Nicholls PG, Croft RP, Withington SG, Smith WCS (2004) Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow up. Int J Epidemiol 33: 337-343.
4. Croft RP, Nicholls PG, Steyerberg EW, Richardus JH, Smith WCS (2000) A clinical prediction rule for nerve function impairment in leprosy patients. Lancet 355: 1603-1606 (Pubitemid 30240505)
5. Suneetha LM, Vardhini D, Suneetha S, Balasubramanian AS, Job CK, et al. (2001) Biochemical aspects of Mycobacterium leprae binding proteins: a review of their role in pathogenesis. Int J Lepr 69: 341-348 (Pubitemid 34492502)
6. Rambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer JL, Yurchenco PD, Campbell KP, Fischetti VA (1998) Role of a-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae. Science 282: 2076-2079.
7. Shetty VP, Antia NH, Jacobs M (1988) The pathology of early leprous neuropathy. J Neurol Sci 88: 115-131.
8. Smith WCS, Anderson AM, Withington SG, van Brakel WH, Croft RP, et al. (2004) Steroid prophylaxis for prevention of nerve function impairment in leprosy: randomised placebo controlled trial (TRIPOD1). Br Med J 328: 1459.
9. SundarRao, Sugamaran DST, Richard J, Smith WCS (2006) Multicentre, double blind, randomised trial of three steroid regimens in the treatment of type 1 reactions in leprosy. Lepr Rev 77: 25-33.
10. Richardus JH, Finlay KM, Croft RP, Smith WCS (1996) Nerve function impairment in leprosy at diagnosis and at completion of MDT: a retrospective cohort study of 786 patients in Bangladesh. Lepr Rev 67: 297-305.
11. van Brakel WH, Nicholls PG, Das L, Barkataki P, Suneetha S, et al. (2005) The INFIR Cohort Study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary patients in North India. Lepr Rev 76: 14-34.
12. Little D, Khanolkar-Young S, Coulthart A, Suneetha S, Lockwood DNJ (2001) Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12 and inducible nitric oxide synthase expression in leprosy Type 1 reactions before and during prednisolone treatment. Infection and Immunity 69: 3413-3417. (Pubitemid 32332240)
13. Dufour A, Candas V (2007) Ageing and thermal responses during passive heat exposure: sweating and sensory aspects. Eur J Appl Physiol 100: 19-26. (Pubitemid 46805258)
14. Jayapal V, Selvibai G, Mahalakshmi K, Pushkala, Regunath K, et al. (2001) Comparative study of anti--PGL-1, anti-35 kDa and anti-lipoarabinomannam assays for serodiagnosis of leprosy. Indian J Lepr 73: 229-237. (Pubitemid 33138214)
15. Narayan R, Maheshwari PK, Desikan KV, Harinath BC (1997) Detection of S-100 protein and anticeramide antibodies in leprosy patients by ELISA. Lepr Rev 68: 117-124. (Pubitemid 27289413)
16. Barnes PF, Chatterjee D, Brennan PJ, Rea TH, Modlin RL (1992) Tumor necrosis factor production in patients with leprosy. Infect Immun 60: 1441-1446
17. van Brakel WH, Nicholls PG, Wilder-Smith EP, Das L, Barkataki P, et al. (2008) Early diagnosis of neuropathy in leprosy - comparing diagnostic tests in a large prospective study (the INFIR Cohort Study). PLoS Negl Trop Dis 2: e212. (Pubitemid 352002929)
18. Sarno EN, Grau GE, Vieira LM, Nery JA (1991) Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states. Clin Exp Immunol 84: 103-108
19. Sehgal VN, Bhattacharya SN, Chattopadhaya D, Saha K (1993) Tumor necrosis factor: status in reactions in leprosy before and after treatment. Int J Dermatol 32: 46-49 (Pubitemid 23189892)