Expression of toll-like receptor 2 on human schwann cells: A mechanism of nerve damage in leprosy

Infection and Immunity

Volumn 71, Issue 3, 2003, Pages 1427-1433

  Oliveira, Rosane B ^a,b   Ochoa, Maria T ^a   Sieling, Peter A ^a   Rea, Thomas H ^c   Rambukkana, Anura ^d   Sarno, Euzenir N ^b   Modlin, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPEPTIDE; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR 2;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEPROSY; MORBIDITY; MYCOBACTERIUM LEPRAE; NERVE INJURY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL;

APOPTOSIS; CELLS, CULTURED; DNA DAMAGE; DROSOPHILA PROTEINS; HUMANS; IMMUNITY, NATURAL; LEPROSY; LIPOPROTEINS; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; SCHWANN CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

EID: 0037373014     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.3.1427-1433.2003     Document Type: Article

References (34)

1. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86-89.
2. Aliprantis, A. O., R.-B. Yang, M. R. Mark, S. Suggett, B. Devaux, J. D. Radolf, G. R. Klimpel, P. Godowski, and A. Zychlinsky. 1999. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 285:736-739.
3. Aliprantis, A. O., R. B. Yang, D. S. Weiss, P. Godowski, and A. Zychlinsky. 2000. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19:3325-3336.
4. Anderson, G. W. J., and J. V. Osterman. 1980. Host defenses in experimental rickettsial pox: genetics of natural resistance to infection. Infect. Immun. 28:132-136.
5. Brightbill, H. D., D. H. Libraty, S. R. Krutzik, R. B. Yang, J. T. Belisle, J. R. Bleharski, M. Maitland, M. V. Norgard, S. E. Plevy, S. T. Smale, P. J. Brennan, B. R. Bloom, P. J. Godowski, and R. L. Modlin. 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285:732-736.
6. Casella, G. T., R. P. Bunge, and P. M. Wood. 1996. Improved method for harvesting human Schwann cells from mature peripheral nerve and expansion in vitro. Glia 17:327-338.
7. Conti, G., A. De Pol, E. Scarpini, F. Vaccina, M. De Riz, P. Baron, M. Tiriticco, and G. Scarlato. 2002. Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells. J. Neuroimmunol. 124:29-35.
8. Cross, A., L. Asher, M. Seguin, L. Yuan, N. Kelly, C. Hammack, J. Sadoff, and P. J. Gemski. 1995. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli. J. Clin. Investig, 96:676-686.
9. Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-3752.
10. Inaba, K., S. Turley, F. Yamaide, T. lyoda, K. Mahnke, M. Inaba, M. Pack, M. Subklewe, B. Sauter, D. Shelf, M. Albert, N. Bhardwaj, I. Mellman, and R. M. Steinman. 1998. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188:2163-2173.
11. Kaufmann, S. H. E. 1988. CD8+ T lymphocytes in intracellular microbial infections. Immunol. Today 9:168-174.
12. Khanolkar-Young, S., N. Rayment, P. M. Brickell, D. R. Katz, S. Vinayakumar, M. J. Colston, and D. N. Lockwood. 1995. Tumour necrosis factor-alpha (TNF-alpha) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions. Clin. Exp. Immunol. 99:196-202.
13. Lemaitre, B., E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983.
14. Marques, M. A., n. Ant, V., E. N. Sarno, P. J. Brennan, and M. C. Pessolani. 2001. Binding of alpha2-laminins by pathogenic and non-pathogenic mycobacteria and adherence to Schwann cells. J. Med. Microbiol. 50:23-28.
15. Medina, E., and R. J. North. 1998. Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility complex haplotype and Nramp1 genotype. Immunology 93:270-274.
16. Medzhitov, R., P. Preston-Hurlburt, and C. A. J. Janeway. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397.
17. Ng, V., G. Zanazzi, R. Timpl, J. F. Talts, J. L. Salzer, P. J. Brennan, and A. Rambukkana. 2000. Role of the cell wall phenolic glycolipidin the peripheral nerve predilection of Mycobacterium leprae. Cell 103:511-524.
18. Noss, E. H., R. K. Pai, T. J. Sellati, J. D. Radolf, J. Belisle, D. T. Golenbock, W. H. Boom, and C. V. Harding. 2001. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J. Immunol. 167:910-918.
19. O'Brien, A. D., D. L. Rosenstreich, I. Scher, G. H. Campbell, R. P. MacDermott, and S. B. Formal. 1980. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol. 124:20-24.
20. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088.
21. Rambukkana, A. 2001. Molecular basis for the peripheral nerve predilection of Mycobacterium leprae. Curr. Opin. Microbiol. 4:21-27.
22. Rambukkana, A., J. L. Salzer, P. D. Yurchenco, and E. I. Tuomanen. 1997. Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain. Cell 88:811-821.
23. Rambukkana, A., G. Zanazzi, N. Tapinos, and J. L. Salzer. 2002. Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells. Science 296:927-931.
24. Ridley, D. S. 1972. The pathogenesis of the early lesions in leprosy. J. Pathol. 111:191-206.
25. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. 34:255-273.
26. Ryan, J. J., K. A. Klein, T. J. Neuberger, J. A. Leftwich, E. H. Westin, S. Kauma, J. A. Fletcher, G. H. DeVries, and T. F. Huff. 1994. Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis. J. Neurosci. Res. 37:415-432.
27. Sarno, E. N., and M. C. Pessolani. 2001. Leprosy. Oldest and most feared disease. Lancet 358(Suppl.):S39.
28. Spierings, E., T. de Boer, B. Wieles, L. B. Adams, E. Marani, and T. H. Ottenhoff. 2001. Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4+ Thl cells: a novel immunopathogenic mechanism of nerve damage in leprosy. J. Immunol. 166:5883-5888.
29. Takeuchi, O., K. Hoshino, and S. Akira. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392-5396.
30. Thoma-Uszynski, S., S. Stenger, O. Takeuchi, M. T. Ochoa, M. Engele, P. A. Sieling, P. F. Barnes, M. Rollinghoff, P. L. Bolcskei, M. Wagner, S. Akira, M. V. Norgard, J. T. Belisle, P. J. Godowski, B. R. Bloom, and R. L. Modlin. 2001. Induction of direct antimicrobial activity through mammalian Toll-like receptors. Science 291:1544-1547.
31. Wang, X., C. Moser, J. P. Louboutin, E. S. Lysenko, D. J. Weiner, J. N. Weiser, and J. M. Wilson. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J. Immunol. 168:810-815.
32. Weinstein, D. L., C. R. Lissner, R. N. Swanson, and A. D. O'Brien. 1986. Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HcJ mice. Cell. Immunol. 102:68-77.
33. Wooten, R. M., Y. Ma, R. A. Yoder, J. P. Brown, J. H. Weis, J. F. Zachary, C. J. Kirschning, and J. J. Weis. 2002. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol. 168:348-355.
34. Yamamura, M., X.-H. Wang, J. D. Ohmen, K. Uyemura, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1992. Cytokine patterns of immunologically mediated tissue damage. J. Immunol. 149:1470-1475.