Synthesis of novel chromene derivatives of expected antitumor activity

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 183-193

  Kandeel, Manal M ^a   Kamal, Aliaa M ^a   Abdelall, Eman K A ^b   Elshemy, Heba A H ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

4 Aryl 4H chromenes; Breast cancer; Cytotoxic activity; Heterocyclic moieties; Microtubule binding agents

Indexed keywords

12 (4 CHLOROPHENYL) 2 (CHLOROPROPYL) 9 ETHOXY 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 12 (4 CHLOROPHENYL) 2 METHYL 9 METHOXY 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 12 (4 CHLOROPHENYL) 9 ETHOXY 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE 2 CARBOXYLATE; 12 (4 CHLOROPHENYL) 9 ETHOXY 2 (4 METHOXYPHENYL) 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 12 (4 CHLOROPHENYL) 9 METHOXY 12H CHROMENO[3,2 E] [1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 12 (4 CHLOROPHENYL) 9 METHOXY 2 (4 METHOXYPHENYL) 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 2 [12 (4 CHLOROPHENYL) 9 ETHOXY 12H CHROMENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 2 YL]ACETONITRILE; 5 (4 CHLOROPHENYL) 4,5 DIHYDRO 4 IMINO 8 METHOXY 3H CHROMENO[2,3 D]PYRIMIDIN 3 AMINE; 5 (4 CHLOROPHENYL) 8 METHOXY 3 METHYL 3H CHROMENO[2,3 D]PYRIMIDIN 4(5H) IMINE; ANTINEOPLASTIC AGENT; CHROMENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MORTALITY;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; BREAST NEOPLASMS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MOLECULAR STRUCTURE;

EID: 84870719322     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.011     Document Type: Article

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