Synthesis of carbon-11-labeled 4-aryl-4H-chromens as new PET agents for imaging of apoptosis in cancer

Applied Radiation and Isotopes

Volumn 68, Issue 1, 2010, Pages 110-116

  Gao, Mingzhang ^a   Wang, Min ^a   Miller, Kathy D ^a   Hutchins, Gary D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 aryl 4H chromenes; Apoptosis; Cancer; Imaging; Positron emission tomography; Radiotracers

Indexed keywords

4-ARYL-4H-CHROMENES; APOPTOSIS; CANCER; IMAGING; RADIOTRACERS;

AMINATION; AMINES; CELL DEATH; EXTRACTION; POSITRONS; RADIOACTIVE TRACERS;

POSITRON EMISSION TOMOGRAPHY;

2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 4,9 DIHYDROPYRANO[3,2 G]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 7 (DIMETHYLAMINO) 4H CHROMENE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 7 METHYL 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 4,9 DIHYDROPYRANO[3,2 G]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 7 (DIMETHYLAMINO) 4H CHROMENE 3 CARBONITRILE C 11; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 7 METHYL 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 HYDROXY 5 METHOXYPHENYL) 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 HYDROXY 5 METHOXYPHENYL) 4,9 DIHYDROPYRANO[3,2 G]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3 HYDROXY 5 METHOXYPHENYL) 7 METHYL 4,7 DIHYDROPYRANO[2,3E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3,5 DIMETHOXYPHENYL) 4,7 DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3,5 DIMETHOXYPHENYL) 4,9 DIHYDROPYRANO[3,2 G]INDOLE 3 CARBONITRILE C 11; 2 AMINO 4 (3,5 DIMETHOXYPHENYL) 7 (DIMETHYLAMINO) 4H CHROMENE 3 CARBONITRILE C 11; 2 AMINO 4 (3,5 DIMETHOXYPHENYL) 7 METHYL 4,7DIHYDROPYRANO[2,3 E]INDOLE 3 CARBONITRILE C 11; 2 AMINO 7 (DIMETHYLAMINO) 4 (3 HYDROXY 5 METHOXYPHENYL) 4H CHROMENE 3 CARBONITRILE C 11; CARBON 11; CARBON DIOXIDE; CHROMENE DERIVATIVE; RADIOISOTOPE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALIGNANT NEOPLASTIC DISEASE; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PRECURSOR; PRIORITY JOURNAL; RADIOCHEMISTRY; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS;

APOPTOSIS; BENZOPYRANS; BREAST NEOPLASMS; CARBON RADIOISOTOPES; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY;

EID: 70449521080     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2009.09.067     Document Type: Article

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