Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males

Clinica Chimica Acta

Volumn 411, Issue 7-8, 2010, Pages 505-509

  Matsunaga, Tetsuro ^a   Gu, Ning ^a,b   Yamazaki, Hanae ^a   Adachi, Tetsuya ^c   Yasuda, Koichiro ^d   Moritani, Toshio ^a   Tsuda, Kinsuke ^a   Nishiyama, Tohru ^a   Nonaka, Masahiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d Saiseikai Noe Hospital   (Japan)

Author keywords

Autonomic nervous system; Heart rate variability; Power spectral analysis

Indexed keywords

ESTROGEN RECEPTOR ALPHA;

ADULT; ALLELE; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIAC AUTONOMIC NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FREQUENCY ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; JAPANESE; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; REST; STANDING; SUPINE POSITION; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADULT; ALLELES; AUTONOMIC NERVOUS SYSTEM; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; REFERENCE VALUES; YOUNG ADULT;

EID: 77649187607     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.12.028     Document Type: Article

References (45)

1. Mendelsohn M.E., Karas R.H. Molecular and cellular basis of cardiovascular gender differences. Science 2005, 308:1583-1587.
2. Mendelsohn M.E., Rosano G.M. Hormonal regulation of normal vascular tone in males. Circ Res 2003, 93:1142-1145.
3. Sudhir K., Komesaroff P.A. Clinical review 110: cardiovascular actions of estrogens in men. J Clin Endocrinol Metab 1999, 84:3411-3415.
4. Mendelsohn M.E. Protective effects of estrogen on the cardiovascular system. Am J Cardiol 2002, 89:12E-17E. discussion 17E-18E.
5. Keene K.L., Mychaleckyj J.C., Smith S.G., et al. Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population. Hum Genet 2008, 123:333-341.
6. Almeida S., Hutz M.H. Genetic variation of estrogen metabolism and the risks of cardiovascular disease. Curr Opin Investig Drugs 2007, 8:814-820.
7. Kjaergaard A.D., Ellervik C., Tybjaerg-Hansen A., et al. Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis. Circulation 2007, 115:861-871.
8. Schuit S.C., Oei H.H., Witteman J.C., et al. Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA 2004, 291:2969-2977.
9. Shearman A.M., Cooper J.A., Kotwinski P.J., et al. Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circ Res 2006, 98:590-592.
10. Shearman A.M., Cupples L.A., Demissie S., et al. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003, 290:2263-2270.
11. Rokach A., Pollak A., Rosen L., et al. Estrogen receptor alpha gene polymorphisms are associated with the angiographic extent of coronary artery disease. J Clin Endocrinol Metab 2005, 90:6556-6560.
12. Xu H., Hou X., Wang N., et al. Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population. Clin Chim Acta 2008, 395:130-133.
13. Ellis J.A., Infantino T., Harrap S.B. Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbeta. J Hypertens 2004, 22:1127-1131.
14. Peter I., Shearman A.M., Zucker D.R., et al. Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study. J Hypertens 2005, 23:2193-2200.
15. Peter I., Kelley-Hedgepeth A., Huggins G.S., et al. Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens 2009, 23:636-644.
16. Lazaros L., Markoula S., Xita N., et al. Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome. Acta Neurol Scand 2008, 117:186-190.
17. Shearman A.M., Cooper J.A., Kotwinski P.J., et al. Estrogen receptor alpha gene variation and the risk of stroke. Stroke 2005, 36:2281-2282.
18. Saleh T.M., Connell B.J. Role of oestrogen in the central regulation of autonomic function. Clin Exp Pharmacol Physiol 2007, 34:827-832.
19. Gokce M., Karahan B., Yilmaz R., Orem C., Erdol C., Ozdemir S. Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhythmia. Int J Cardiol 2005, 99:373-379.
20. Rosa Brito-Zurita O., Posadas-Romero C., Hermosillo A.G., et al. Estrogen effect on heart rate variability in hypertensive postmenopausal women. Maturitas 2003, 44:39-48.
21. Wyss J.M., Carlson S.H. Effects of hormone replacement therapy on the sympathetic nervous system and blood pressure. Curr Hypertens Rep 2003, 5:241-246.
22. Rosano G.M., Patrizi R., Leonardo F., et al. Effect of estrogen replacement therapy on heart rate variability and heart rate in healthy postmenopausal women. Am J Cardiol 1997, 80:815-817.
23. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996, 93:1043-1065.
24. Pumprla J., Howorka K., Groves D., Chester M., Nolan J. Functional assessment of heart rate variability: physiological basis and practical applications. Int J Cardiol 2002, 84:1-14.
25. Hadase M., Azuma A., Zen K., et al. Very low frequency power of heart rate variability is a powerful predictor of clinical prognosis in patients with congestive heart failure. Circ J 2004, 68:343-347.
26. Whitsel E.A., Raghunathan T.E., Pearce R.M., et al. RR interval variation, the QT interval index and risk of primary cardiac arrest among patients without clinically recognized heart disease. Eur Heart J 2001, 22:165-173.
27. La Rovere M.T., Pinna G.D., Maestri R., et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003, 107:565-570.
28. Singh J.P., Larson M.G., Tsuji H., Evans J.C., O'Donnell C.J., Levy D. Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension 1998, 32:293-297.
29. Bigger J.T., Fleiss J.L., Rolnitzky L.M., Steinman R.C. Frequency domain measures of heart period variability to assess risk late after myocardial infarction. J Am Coll Cardiol 1993, 21:729-736.
30. Dekker J.M., Crow R.S., Folsom A.R., et al. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis Risk In Communities. Circulation 2000, 102:1239-1244.
31. Komesaroff P.A., Fullerton M., Esler M.D., Dart A., Jennings G., Sudhir K. Low-dose estrogen supplementation improves vascular function in hypogonadal men. Hypertension 2001, 38:1011-1016.
32. Molvarec A., Nagy B., Kovacs M., et al. Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms. Clin Chim Acta 2007, 380:157-164.
33. Brown T.E., Beightol L.A., Koh J., Eckberg D.L. Important influence of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol 1993, 75:2310-2317.
34. Yasuda K., Matsunaga T., Adachi T., Aoki N., Tsujimoto G., Tsuda K. Adrenergic receptor polymorphisms and autonomic nervous system function in human obesity. Trends Endocrinol Metab 2006, 17:269-275.
35. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
36. Okura T., Koda M., Ando F., Niino N., Ohta S., Shimokata H. Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution. Int J Obes Relat Metab Disord 2003, 27:1020-1027.
37. Brook R.D., Julius S. Autonomic imbalance, hypertension, and cardiovascular risk. Am J Hypertens 2000, 13:112S-122S.
38. Thayer J.F., Lane R.D. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol 2007, 74:224-242.
39. Fifer W.P., Fingers S.T., Youngman M., Gomez-Gribben E., Myers M.M. Effects of alcohol and smoking during pregnancy on infant autonomic control. Dev Psychobiol 2009, 51:234-242.
40. Munjal S., Koval T., Muhammad R., et al. Heart rate variability increases with reductions in cigarette smoke exposure after 3days. J Cardiovasc Pharmacol Ther 2009, 14:192-198.
41. Sudhir K., Chou T.M., Chatterjee K., et al. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation 1997, 96:3774-3777.
42. Sudhir K., Chou T.M., Messina L.M., et al. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet 1997, 349:1146-1147.
43. Lieberman E.H., Gerhard M.D., Uehata A., et al. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 1994, 121:936-941.
44. Lew R., Komesaroff P., Williams M., Dawood T., Sudhir K. Endogenous estrogens influence endothelial function in young men. Circ Res 2003, 93:1127-1133.
45. Nyholt D.R. Genetic case-control association studies-correcting for multiple testing. Hum Genet 2001, 109:564-567.