Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6723-6730

  Kurt, Ozlem ^a   Yilmaz Aydogan, Hulya ^a   Uyar, Mehmet ^b   Isbir, Turgay ^c   Seyhan, Mehmet Fatih ^a   Can, Ayse ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b Uskudar State Hospital   (Turkey)

^c YEDITEPE UNIVERSITY   (Turkey)

Author keywords

Bone mineral density; Estrogen receptor; Osteoporosis; Polymorphism; Vitamin D receptor

Indexed keywords

ESTROGEN RECEPTOR ALPHA; VITAMIN D RECEPTOR;

ADULT; AGED; ARTICLE; BONE DENSITOMETRY; BONE DENSITY; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTROGEN RECEPTOR ALPHA GENE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; TURKEY (REPUBLIC); VITAMIN D RECEPTOR GENE;

ADULT; AGED; BONE DENSITY; CASE-CONTROL STUDIES; ESTROGEN RECEPTOR ALPHA; FEMALE; FEMUR NECK; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HIP; HUMANS; LOGISTIC MODELS; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; RECEPTORS, CALCITRIOL; RISK FACTORS; TURKEY;

EID: 84864278905     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1496-0     Document Type: Article

References (46)

1. Gennari L, Merlotti D, De Paola V, Calabrò A, Becherini L, Martini G, Nuti R (2005) Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. Am J Epidemiol 161:307-320 (Pubitemid 40256202)
2. Pérez A, Ulla M, García B, Lavezzo M, Elías E, Binci M, Rivoira M, Centeno V, Alisio A, de Talamoni NT (2008) Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab 26:358-365 (Pubitemid 351950699)
3. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CC Jr (1991) Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importence of gene interaction on heritability estimates. J Bone Miner Res 6:561-567
4. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80:706-710 (Pubitemid 18003941)
5. Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11:530-534 (Pubitemid 26109073)
6. Wang CL, Tang XY, Chen WQ, Su YX, Zhang CX, Chen YM (2007) Association of estrogen receptor a gene polymorphisms with bone mineral density in Chinese women: a meta-analysis. Osteoporos Int 18:295-305
7. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134-139 (Pubitemid 16105150)
8. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (1986) Sequence and expression of human estrogen receptor complementary DNA. Science 231:1150-1154 (Pubitemid 16016313)
9. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M, Orimo H (1996) Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11:306-311 (Pubitemid 26076380)
10. Willing M, Sowers M, Aron D, Clark MK, Burns T, Bunten C, Crutchfield M, D'Agostino D, Jannausch M (1998) Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res 13:695-705 (Pubitemid 28163021)
11. Ivanova JT, Doukova PB, Boyanov MA, Popivanov PR (2007) PvuII and XbaI polymorphisms of the estrogen receptor gene and bone mineral density in a Bulgarian population sample. Hormones (Athens) 6:36-43
12. Yamada Y, Ando F, Niino N, Ohta S, Shimokata H (2002) Association of polymorphisms of the estrogen receptor a gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med 80:452-460 (Pubitemid 34754211)
13. Nam HS, Shin MH, Kweon SS, Park KS, Sohn SJ, Rhee JA, Choi JS, Son MH (2005) Association of estrogen receptor-a gene polymorphisms with bone mineral density in postmenopausal Korean women. J Bone Miner Metab 23:84-89
14. Bagger YZ, Jørgensen HL, Heegaard AM, Bayer L, Hansen L, Hassager C (2000) No major effect of estrogen receptor gene polymorphisms on bone mineral density or bone loss in post-menopausal Danish women. Bone 26:111-116 (Pubitemid 30029202)
15. Becherini L, Gennari L, Masi L, Mansani R, Massart F, Morelli A, Falchetti A, Gonnelli S, Fiorelli G, Tanini A, Brandi ML (2000) Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor a gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet 9:2043-2050 (Pubitemid 30642669)
16. Brown MA, Haughton MA, Grant SF, Gunnell AS, Henderson NK, Eisman JA (2001) Genetic control of bone density and turnover: role of the collagen 1a1, estrogen receptor, and vitamin D receptor genes. J Bone Miner Res 16:758-764 (Pubitemid 32230605)
17. Jian WX, Yang YJ, Long JR, Li YN, Deng FY, Jiang DK, Deng HW (2005) Estrogen receptor a gene relationship with peak bone mass and body mass index in Chinese nuclear families. J Hum Genet 50:477-482
18. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW (1998) The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13:325-349 (Pubitemid 28146215)
19. Ranganathan P (2009) Genetics of bone loss in rheumatoid arthritis-role of vitamin D receptor polymorphisms. Rheumatology (Oxford) 48:342-346
20. Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishi-waki E, Tatsumi S, Inoue Y, Morita K, Takeda E, Pike JW (1997) Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol 11:1165-1179 (Pubitemid 27278838)
21. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feld-man D (1996) The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 11:1850-1855 (Pubitemid 26425676)
22. Vidal C, Grima C, Brincat M, Megally N, Xuereb-Anastasi A (2003) Associations of polymorphisms in the vitamin D receptorgene (BsmI and FokI) with bone mineral density in postmeno-pausal women in Malta. Osteoporos Int 14:923-928 (Pubitemid 38009533)
23. Mitra S, Desai M, Ikram Khatkhatay M (2006) Vitamin D receptor gene polymorphisms and bone mineral density in post-menopausal Indian women. Maturitas 55:27-35 (Pubitemid 44093924)
24. Falchetti A, Sferrazza C, Cepollaro C, Gozzini A, Del Monte F, Masi L, Napoli N, Di Fede G, Cannone V, Cusumano G, Pan-dolfo MC, Rini GB, Tanini A, Brandi ML (2007) FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa. Calcif Tissue Int 80:15-20 (Pubitemid 46095746)
25. Zajickova K, Zofkova I, Bahbouh R, Krepelova A (2002) Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass. Physiol Res 51:501-509 (Pubitemid 36119218)
26. Langdahl BL, Gravholt CH, Brixen K, Eriksen EF (2000) Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures. Eur J Clin Invest 30:608-617 (Pubitemid 30453661)
27. Douroudis K, Tarassi K, Ioannidis G, Giannakopoulos F, Mout-satsou P, Thalassinos N, Papasteriades C (2003) Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin. Maturitas 45:191-197 (Pubitemid 36724874)
28. Morita A, Iki M, Dohi Y, Ikeda Y, Kagamimori S, Kagawa Y, Matsuzaki T, Yoneshima H, Marumo F, JPOS Study Group (2004) Prediction of bone mineral density from vitamin D receptor polymorphisms is uncertain in representative samples of Japanese women. The Japanese Population-based Osteoporosis (JPOS) Study. Int Epidemiol 33:979-988 (Pubitemid 39429990)
29. Macdonald HM, McGuigan FE, Stewart A, Black AJ, Fraser WD, Ralston S, Reid DM (2006) Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women. J Bone Miner Res 21:151-162 (Pubitemid 43023237)
30. Wengreen H, Cutler DR, Munger R, Willing M (2006) Vitamin D receptor genotype and risk of osteoporotic hip fracture in elderly women of Utah: an effect modified by parity. Osteoporos Int 17:1146-1153
31. World Health Organization Study Group (1994) Assesment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser 843:1-129
32. Miller SA, Dykes DD, Poleskey HS (1998) Simples salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215
33. van Meurs JB, Schuit SC, Weel AE, van der Klift M, Bergink AP, Arp PP, Colin EM, Fang Y, Hofman A, van Duijn CM, van Leeuwen JP, Pols HA, Uitterlinden AG (2002) Association of 5′ estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. Hum Mol Genet 12:1745-1754
34. Onland-Moret NC, van Gils CH, Roest M, Grobbee DE, Peeters PH (2005) The estrogen receptor a gene and breast cancer risk (The Netherlands). Cancer Causes Control 16:1195-1202 (Pubitemid 46179504)
35. Curran JE, Vaughan T, Lea RA, Weinstein SR, Morrison NA, Griffiths LR (1999) Association of a vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer 83:723-726
36. Ralston SH (2002) Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 87:2460-2466 (Pubitemid 34655301)
37. Salmén T, Heikkinen AM, Mahonen A, Kröger H, Komulainen M, Saarikoski S, Honkanen R, Mäenpää PH (2000) Early post-menopausal bone loss is associated with PvuII estrogen receptor gene polymorphism in Finnish women: effect of hormone replacement therapy. J Bone Miner Res 15:315-321
38. Mitra S, Desai M, Khatkhatay MI (2006) Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women. Mol Genet Metab 87:80-87 (Pubitemid 43003771)
39. Rapuri PB, Gallagher JC, Knezetic JA, Haynatzka V (2006) Estrogen receptor alpha gene polymorphisms are associated with changes in bone remodeling markers and treatment response to estrogen. Maturitas 53:371-379
40. Erdogan MO, Yildiz H, Artan S, Solak M, Taşcioǧlu F, Dündar U, Eser B, Colak E (2011) Association of estrogen receptor alpha and collagen type I alpha I gene polymorphisms with bone mineral density in postmenopausal women. Osteoporos Int 22:1219-1225
41. Durusu Tanriover M, Bora Tatar G, Uluturk TD, Dayangac Erden D, Tanriover A, Kilicarslan A, Oz SG, Erdem Yurter H, Sozen T, Sain Guven G (2010) Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol 29:1285-1293
42. Seremak-Mrozikiewicz A, Drews K, Mrozikiewicz PM, Bart-kowiak-Wieczorek J, Marcinkowska M, Wawrzyniak A, Slomski R, Kalak R, Czerny B, Horst-Sikorska W (2009) Correlation of vitamin D receptor gene (VDR) polymorphism with osteoporotic changes in Polish postmenopausal women. Neuro Endocrinol Lett 30:540-546
43. Duman BS, Tanakol R, Erensoy N, Oztürk M, Yilmazer S (2004) Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Med Princ Pract 13:260-266 (Pubitemid 39179139)
44. Dinçel E, Sepici-Dinçel A, Sepici V, Ozsoy H, Sepici B (2008) Hip fracture risk and different gene polymorphisms in the Turkish population. Clinics (Sao Paulo) 63:645-650
45. Uysal AR, Sahin M, Gursoy A, Gullu S (2008) Vitamin D receptor gene polymorphism and osteoporosis in the Turkish population. Genet Test 12:591-594
46. Malacara JM, Pérez-Luque EL, Martínez-Garza S, Sánchez-Marín FJ (2004) The relationship of estrogen receptor-alpha polymorphism with symptoms and other characteristics in post-menopausal women. Maturitas 49:163-169 (Pubitemid 39330429)