A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco

Infection, Genetics and Evolution

Volumn 13, Issue 1, 2013, Pages 162-167

  Hamdi, Salsabil ^a   Ejghal, Rajaa ^a   Idrissi, Mouna ^b   Ezzikouri, Sayeh ^a   Hida, Mohammed ^b   Soong, Lynn ^c   Amarouch, Hamid ^d   Lemrani, Meryem ^a  

^a Institut Pasteur du Maroc   (Morocco)

^b HASSAN II UNIVERSITY HOSPITAL   (Morocco)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d FACULTÉ DES SCIENCES AIN CHOCK   (Morocco)

Author keywords

MBL2 variants; North Morocco; Susceptibility; Visceral leishmaniasis

Indexed keywords

MANNOSE BINDING LECTIN 2;

ARTICLE; CHILD; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA INFANTUM; MAJOR CLINICAL STUDY; MANNOSE BINDING LECTIN 2 GENE; MOROCCO; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; SEQUENCE ANALYSIS; VISCERAL LEISHMANIASIS;

ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CODON; GENE FREQUENCY; GENOTYPE; HUMANS; INFANT; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MANNOSE-BINDING LECTIN; MOROCCO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

LEISHMANIA INFANTUM;

EID: 84870660559     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2012.09.002     Document Type: Article

References (35)

1. Alonso D.P., Ferreira A.F., Ribolla P.E., de Miranda Santos I.K., do Socorro Pires e Cruz M., Aecio de Carvalho F., Abatepaulo A.R., Lamounier Costa D., Werneck G.L., Farias T.J., Soares M.J., Costa C.H. Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications. J .Infect. Dis. 2007, 195:1212-1217.
2. Bernig T., Taylor J.G., Foster C.B., Staats B., Yeager M., Chanock S.J. Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection. Genes. Immun. 2004, 5:461-476.
3. Bouratbine A., Moussa H., Aoun K., Ben Ismail R. Anthropologic research and understanding pediatric visceral leishmaniasis in Tunisia. Bull. Soc. Pathol. Exot. 1998, 91:183-187.
4. Cosar H., Ozkinay F., Onay H., Bayram N., Bakiler A.R., Anil M., Can D., Ozkinay C. Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children. Eur. J. Clin. Microbiol. Infect. Dis. 2008, 27:1165-1169.
5. Desjeux P. The increase in risk factors for leishmaniasis worldwide. Trans. R. Soc. Trop. Med. Hyg. 2001, 95:239-243.
6. Dommett R.M., Klein N., Turner M.W. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens. 2006, 68:193-209.
7. Ezekowitz R.A. Role of the mannose-binding lectin in innate immunity. J. Infect. Dis 2003, 187(Suppl 2):S335-S339.
8. Garred P., Harboe T., Oettinger., et al. Dual role of mannan-binding protein in infections: Another case of heterosis? Eur. J. Immunogenet. 1994, 21:125-131.
9. Garred P., Larsen F., Madsen H., Koch C. Mannose binding lectin deficiency-revisited. Mol. Immunol. 2003, 40:73-84.
10. Garred P., Larsen F., Seyfarth J., Fujita R., Madsen H.O. Mannose-binding lectin and its genetic variants. Genes. Immun. 2006, 7:85-94.
11. Garred P., Madsen H., Kurtzhals J., Lamm L., Thiel S., Hey A., Svejgaard X. Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans. Eur. J. Immunogenet. 1992, 19:403-412.
12. Garred P., Thiel S., Madsen H.O., Ryder L.P., Jensenius J.C., Svejgaard A. Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations. Clin. Exp. Immunol. 1992, 90:517-521.
13. Gustincich S., Manfioletti G., Del Sal G., Schneider C., Carninci P. A fast method for high-quality genomic DNA extraction from whole human blood. Biotechniques 1991, 11(298-300):302.
14. Hamdi S., Faouzi A., Ejghal R., Laamrani A., Amarouch A., Hassar M., Lemrani M. Socio-economic and environmental factors associated with Montenegro skin test positivity in an endemic area of visceral leishmaniasis in northern Morocco. Microbiology Research. 2012, 3:28-33.
15. Herwaldt B.L. Leishmaniasis. Lancet. 1999, 354:1191-1199.
16. Holmberg V., Schuster F., Dietz E., Sagarriga Visconti J.C., Anemana S.D., Bienzle U., Mockenhaupt F.P. Mannose-binding lectin variant associated with severe malaria in young African children. Microbes. Infect. 2008, 10:342-348.
17. Ip W.K., Takahashi K., Ezekowitz R.A., Stuart L.M. Mannose-binding lectin and innate immunity. Immunol. Rev. 2009, 230:9-21.
18. Koch A., Melbye M., Sorensen P., Homoe P., Madsen H.O., Molbak K., Hansen C.H., Andersen L.H., Hahn G.W., Garred P. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. Jama. 2001, 285:1316-1321.
19. Liu W., Zhang F., Xin Z., Zhao Q., Wu X., Zhang P. Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population. Int. J. of. Tuberc. Lung. Dis. 2006, 10:1098-1103.
20. Madsen H., Garred P., Kurtzhals J., Lamm L., Ryder L., Thiel S., Svejgaard A. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics. 1994, 40:37-44.
21. Madsen H., Garred P., Thiel S., Kurtzhals J.A., Lamm L.U., Ryder L.P., Svejgaard A. Interplay between promoter and structural gene variants control basal serum level of mannan- binding protein. J. Immunol. 1995, 155:3013-3020.
22. Madsen H.O., Satz M.L., Hogh B., Svejgaard A., Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J. Immunol. 1998, 161:3169-3175.
23. Marty P., Le Fichoux Y., Giordana D., Brugnetti A. Leishmanin reaction in the human population of a highly endemic focus of canine leishmaniasis in Alpes-Maritimes. France. Trans. R. Soc. Trop. Med. Hyg. 1992, 86:249-250.
24. Meddeb-Garnaoui A., Gritli S., Garbouj S., Ben Fadhel M., El Kares R., Mansour L., Kaabi B., Chouchane L., Ben Salah A., Dellagi K. Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis. Hum. Immunol. 2001, 62:509-517.
25. Melo M.N., Mayrink W., da Costa C.A., Magalhaes P.A., Dias M., Williams P., Araujo F.G., Coelho M.V., Batista S.M. Standardization of the Montenegro antigen. Rev. Inst. Med. Trop. Sao Paulo. 1977, 19:161-164.
26. Minchinton R., Dean M.M., Clark T., Heatley S., Mullighan C.G., Scand. Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population. J. Immunol. 2002, 56:630-641.
27. Ministry of Health. 2008. Rapport annuel d'activité, Maroc, Direction de l'Epidémiologie et de la Lutte contre les maladies.
28. Santos I.K., Costa C.H., Krieger H., Feitosa M.F., Zurakowski D., Fardin B., Gomes R.B., Weiner D.L., Harn D.A., Ezekowitz R.A., Epstein J.E. Mannan-binding lectin enhances susceptibility to visceral leishmaniasis. Infect. Immun. 2001, 69:5212-5215.
29. Thye T., Niemann S., Walter K., Homolka S., Intemann C.D., Chinbuah M.A., Enimil A., Gyapong J., Osei i., Owusu-Dabo E., Rüsch-Gerdes S., Horstmann R., Ehlers S., Meyer C. Variant G57E of Mannose Binding Lectin Associated with Protection against Tuberculosis Caused by Mycobacterium africanum but not by M. tuberculosis. PLoS ONE. 2011, 6:e20908.
30. Turner M. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol. Today. 1996, 17:532-540.
31. Turner M., Lipscombe R., Levinsky R., Lau Y.L., Hill A.V., Summerfield J.A., Sumiya M. Mutations in the human mannose binding protein gene: their frequencies in three distinct populations and relationship to serum levels of the protein. Immunodeficiency. 1993, 4:285-287.
32. Turner M.W. The role of mannose-binding lectin in health and disease. Mol. Immunol. 2003, 40:423-429.
33. Turner M.W., Hamvas R.M. Mannose-binding lectin: structure, function, genetics and disease associations. Rev. Immunogenet. 2000, 2:305-322.
34. Wilson M.E., Jeronimo S., Pearson R. Immunopathogenesis of infection with the visceralizing Leishmania species. Microb. Pathog. 2005, 38:147-160.
35. World Health Organisation. 2000. The Leishmaniases and Leishmania/HIV Co-infections, Geneva.