Mannose-binding lectin variant associated with severe malaria in young African children

Microbes and Infection

Volumn 10, Issue 4, 2008, Pages 342-348

  Holmberg, Ville ^a,b   Schuster, Friederike ^a   Dietz, Ekkehart ^a   Sagarriga Visconti, J Chantale ^a   Anemana, Sylvester D ^c   Bienzle, Ulrich ^a   Mockenhaupt, Frank P ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

^c MINISTRY OF HEALTH   (Ghana)

Author keywords

Anemia; Innate immunity; Malaria; Mannose binding lectin; MBL2

Indexed keywords

MANNOSE BINDING LECTIN; MANNOSE BINDING LECTIN 2;

AFRICA; ANEMIA; ARTICLE; CHILD; COMPLEMENT SYSTEM; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFANT; INFECTION SENSITIVITY; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALARIA; MALE; MISSENSE MUTATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN VARIANT; PROTOZOAL INFECTION;

ANEMIA; ANIMALS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENE FREQUENCY; GHANA; HETEROZYGOTE; HUMANS; INFANT; MALARIA; MALE; MANNOSE-BINDING LECTIN; MUTATION, MISSENSE; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PROTEIN BINDING;

PLASMODIUM FALCIPARUM;

EID: 43049084430     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2007.12.008     Document Type: Article

References (33)

1. Kwiatkowski D.P. How malaria has affected the human genome and what human genetics can teach us about malaria. Am. J. Hum. Genet. 77 (2005) 171-192
2. Mockenhaupt F.P., Cramer J.P., Hamann L., Stegemann M.S., Eckert J., Oh N.R., et al. Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 177-182
3. Jack D.L., and Turner M.W. Anti-microbial activities of mannose-binding lectin. Biochem. Soc. Trans. 31 (2003) 753-757
4. Bouwman L.H., Roep B.O., and Roos A. Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity. Hum. Immunol. 67 (2006) 247-256
5. Madsen H.O., Garred P., Thiel S., Kurtzhals J.A., Lamm L.U., Ryder L.P., et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J. Immunol. 155 (1995) 3013-3020
6. Larsen F., Madsen H.O., Sim R.B., Koch C., and Garred P. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J. Biol. Chem. 279 (2004) 21302-21311
7. Casanova J.L., and Abel L. Human mannose-binding lectin in immunity: friend, foe, or both?. J. Exp. Med. 199 (2004) 1295-1299
8. Bellamy R., Ruwende C., McAdam K.P., Thursz M., Sumiya M., Summerfield J., et al. Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Q.J. Med. 91 (1998) 13-18
9. Garred P., Nielsen M.A., Kurtzhals J.A., Malhotra R., Madsen H.O., Goka B.Q., et al. Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes. Infect. Immun. 71 (2003) 5245-5253
10. Mombo L.E., Ntoumi F., Bisseye C., Ossari S., Lu C.Y., Nagel R.L., et al. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am. J. Trop. Med. Hyg. 68 (2003) 186-190
11. Boldt A.B., Luty A., Grobusch M.P., Dietz K., Dzeing A., Kombila M., et al. Association of a new mannose-binding lectin variant with severe malaria in Gabonese children. Genes Immun. 7 (2006) 393-400
12. Luty A.J., Kun J.F., and Kremsner P.G. Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. J. Infect. Dis. 178 (1998) 1221-1224
13. Mockenhaupt F.P., Ehrhardt S., Burkhardt J., Bosomtwe S.Y., Laryea S., Anemana S.D., et al. Manifestation and outcome of severe malaria in children in northern Ghana. Am. J. Trop. Med. Hyg. 71 (2004) 167-172
14. Mockenhaupt F.P., Ehrhardt S., Cramer J.P., Otchwemah R.N., Anemana S.D., Goltz K., et al. Hemoglobin C and resistance to severe malaria in Ghanaian children. J. Infect. Dis. 190 (2004) 1006-1009
15. Hanley J.A. A heuristic approach to the formulas for population attributable fraction. J. Epidemiol. Community Health 55 (2001) 508-514
16. Roozendaal R., and Carroll M.C. Emerging patterns in complement-mediated pathogen recognition. Cell 125 (2006) 29-32
17. Thiel S., Steffensen R., Christensen I.J., Ip W.K., Lau Y.L., Reason I.J., et al. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun. 8 (2007) 154-163
18. Madsen H.O., Satz M.L., Hogh B., Svejgaard A., and Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J. Immunol. 161 (1998) 3169-3175
19. Garred P., Larsen F., Madsen H.O., and Koch C. Mannose-binding lectin deficiency-revisited. Mol. Immunol. 40 (2003) 73-84
20. Steffensen R., Thiel S., Varming K., Jersild C., and Jensenius J.C. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J. Immunol. Methods 241 (2000) 33-42
21. Thiel S., Holmskov U., Hviid L., Laursen S.B., and Jensenius J.C. The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin. Exp. Immunol. 90 (1992) 31-35
22. Aidoo M., Terlouw D.J., Kolczak M.S., McElroy P.D., ter Kuile F.O., Kariuki S., et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 359 (2002) 1311-1312
23. Biezeveld M.H., Kuipers I.M., Geissler J., Lam J., Ottenkamp J.J., Hack C.E., et al. Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease. Lancet 361 (2003) 1268-1270
24. Peterslund N.A., Koch C., Jensenius J.C., and Thiel S. Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 358 (2001) 637-638
25. Hibberd M.L., Sumiya M., Summerfield J.A., Booy R., and Levin M. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group. Lancet 353 (1999) 1049-1053
26. Menendez C., Fleming A.F., and Alonso P.L. Malaria-related anaemia. Parasitol. Today 16 (2000) 469-476
27. Sorensen R., Thiel S., and Jensenius J.C. Mannan-binding-lectin-associated serine proteases, characteristics and disease associations. Springer Semin. Immunopathol. 27 (2005) 299-319
28. Bernig T., Taylor J.G., Foster C.B., Staats B., Yeager M., and Chanock S.J. Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection. Genes Immun. 5 (2004) 461-476
29. Verdu P., Barreiro L.B., Patin E., Gessain A., Cassar O., Kidd J.R., et al. Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles. Hum. Mol. Genet. 15 (2006) 2650-2658
30. Dahl M., Tybjaerg-Hansen A., Schnohr P., and Nordestgaard B.G. A population-based study of morbidity and mortality in mannose-binding lectin deficiency. J. Exp. Med. 199 (2004) 1391-1399
31. Soborg C., Madsen H.O., Andersen A.B., Lillebaek T., Kok-Jensen A., and Garred P. Mannose-binding lectin polymorphisms in clinical tuberculosis. J. Infect. Dis. 188 (2003) 777-782
32. Gordon A.C., Waheed U., Hansen T.K., Hitman G.A., Garrard C.S., Turner M.W., et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 25 (2006) 88-93
33. von Kalckreuth V., Evans J.A., Timmann C., Kuhn D., Agbenyega T., Horstmann R.D., et al. Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality. J. Infect. Dis. 194 (2006) 949-957