Single-round, multiplexed antibody mimetic design through mRNA display

Angewandte Chemie - International Edition

Volumn 51, Issue 50, 2012, Pages 12449-12453

  Olson, C Anders ^a   Nie, Jeff ^b   Diep, Jonathan ^a   Al Shyoukh, Ibrahim ^a   Takahashi, Terry T ^c   Al Mawsawi, Laith Q ^a   Bolin, Jennifer M ^b   Elwell, Angela L ^b   Swanson, Scott ^b   Stewart, Ron ^b   Thomson, James A ^b,d,e   Soh, H Tom ^e   Roberts, Richard W ^c   Sun, Ren ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MORGRIDGE INSTITUTE FOR RESEARCH   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibody mimetics; directed evolution; ligand design; mRNA display; selection methods

Indexed keywords

DIRECTED EVOLUTION; LIGAND DESIGN; MIMETICS; MRNA-DISPLAY; SELECTION METHODS;

ITERATIVE METHODS; LIGANDS; MAGNETIC SEPARATION;

ANTIBODIES;

ANTIBODY; BIOMIMETIC MATERIAL; FIBRONECTIN; IMMUNOGLOBULIN FC FRAGMENT; LIGAND; MALTOSE BINDING PROTEIN; MESSENGER RNA;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE LIBRARY; HUMAN; IMMUNOMAGNETIC SEPARATION; ISOLATION AND PURIFICATION; METABOLISM;

AMINO ACID SEQUENCE; ANTIBODIES; BIOMIMETIC MATERIALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRONECTINS; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOMAGNETIC SEPARATION; LIGANDS; MALTOSE-BINDING PROTEINS; RNA, MESSENGER;

EID: 84870621677     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201207005     Document Type: Article

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