mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17512-17520

  Liao, Hsiang I ^a   Olson, C Anders ^c   Hwang, Seungmin ^a   Deng, Hongyu ^a   Wong, Elaine ^a   Baric, Ralph S ^d   Roberts, Richard W ^e   Sun, Ren ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d IL   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CELLULAR FUNCTION; CORONAVIRUS; DIRECTED EVOLUTION; FIBRONECTIN TYPE III; HIGH AFFINITY; HOST CELLS; HOT SPOT; HUMAN FIBRONECTIN; IN-CELL; IN-VIVO; INFECTED CELLS; MAMMALIAN CELLS; MRNA-DISPLAY; N-TERMINAL DOMAINS; NUCLEOCAPSID; NUCLEOCAPSID PROTEINS; PROTEIN AFFINITY; PROTEIN SURFACE; SEVERE ACUTE RESPIRATORY SYNDROME; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SYNERGISTIC INHIBITION; VIRAL REPLICATION; VIRUS REPLICATION;

MAMMALS;

CELL MEMBRANES;

FIBRONECTIN; MESSENGER RNA; NUCLEOCAPSID PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO CULTURE; MAMMAL CELL; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN VARIANT; SARS CORONAVIRUS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOPRECIPITATION; KIDNEY; MOLECULAR SEQUENCE DATA; NUCLEOCAPSID PROTEINS; PEPTIDE LIBRARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SARS VIRUS; SEQUENCE HOMOLOGY, AMINO ACID; SEVERE ACUTE RESPIRATORY SYNDROME; VERO CELLS; VIRUS REPLICATION;

MAMMALIA; SARS CORONAVIRUS;

EID: 67650555401     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M901547200     Document Type: Article

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