Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Kuipers, Maria T ^a   Aslami, Hamid ^a   Vlaar, Alexander P J ^a   Juffermans, Nicole P ^a   Tuip de Boer, Anita M ^a   Hegeman, Maria A ^a   Jongsma, Geartsje ^a   Roelofs, Joris J T H ^a   van der Poll, Tom ^a   Schultz, Marcus J ^a   Wieland, Catharina W ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; CRYOPYRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GALLIUM CITRATE GA 67; I KAPPA B ALPHA; IMMUNOGLOBULIN M; INFLAMMASOME; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; RASBURICASE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; URATE OXIDASE; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL PERMEABILITY; DRUG EFFICACY; GENE EXPRESSION; HEART RATE; HEART SURGERY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; OPERATION DURATION; PNEUMONIA; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; VENTILATOR INDUCED LUNG INJURY;

ACUTE LUNG INJURY; ADULT; ALLOPURINOL; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICROVESSELS; PULMONARY ALVEOLI; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; URATE OXIDASE; URIC ACID; VENTILATOR-INDUCED LUNG INJURY;

MURINAE; MUS;

EID: 84870619731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050559     Document Type: Article

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