Reactive species and pulmonary edema

Expert Review of Respiratory Medicine

Volumn 3, Issue 5, 2009, Pages 487-496

  Iles, Karen E ^a,b   Song, Weifeng ^a   Miller, David W ^a   Dickinson, Dale A ^b   Matalon, Sadis ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antioxidants; Free radicals; Pulmonary edema; Reactive oxygen and nitrogen species; RONS; Sodium transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; EPITHELIAL SODIUM CHANNEL; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; POLYUNSATURATED FATTY ACID; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SODIUM ION; SUPEROXIDE DISMUTASE;

ALTITUDE DISEASE; DISEASE ASSOCIATION; FLUID BALANCE; HISTOPATHOLOGY; HUMAN; LUNG EDEMA; LUNG FLUID; MOLECULAR MECHANICS; NONCARDIOGENIC LUNG EDEMA; NONHUMAN; OXIDATIVE STRESS; REVIEW; RISK ASSESSMENT; SODIUM TRANSPORT; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT OBSTRUCTION;

EID: 73449144815     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.09.41     Document Type: Review

References (59)

1. Lehavi O, Leiba A, Dahan Y et al. Lessons learned from chlorine intoxications in swimming pools: the challenge of pediatric mass toxicological events. Prehosp. Disaster Med. 23, 90-95 (2008).
2. Leustik M, Doran S, Bracher A et al. Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am. J. Physiol. Lung Cell Mol. Physiol. 295, L733-L743 (2008).
3. Taylor G, Miller H, Shulman H, DeLacy J, Maggisano R. Controversies in the management of pulmonary contusion. Can. J. Surg. 25, 167-170 (1982).
4. Reske A, Seiwerts M, Reske A, Gottschaldt U, Schreiter D. Early recovery from posttraumatic acute respiratory distress syndrome. Clin. Physiol. Funct. Imaging 26, 376-379 (2006).
5. Tariq S, Sadaf T. Images in clinical medicine. Reexpansion pulmonary edema after treatment of pneumothorax. N. Engl. J. Med. 354, 2046 (2006).
6. Sohara Y. Reexpansion pulmonary edema. Ann. Thorac. Cardiovasc. Surg. 14, 205-209 (2009).
7. Conen A, Joos L, Bingisser R. Ipsilateral reexpansion pulmonary edema after drainage of a spontaneous pneumothorax: a case report. J. Med. Case Reports 1, 107 (2007).
8. Akindipe O, Fernandez-Bussy S, Staples E, Baz M. Late unilateral pulmonary edema in single lung transplant recipients. J. Heart Lung Transplant. 27, 1055-1058 (2008).
9. Triulzi D. Transfusion-related acute lung injury: current concepts for the clinician. Anesth. Analg. 108, 770-776 (2009).
10. Biswal S, Remick D. Sepsis: redox mechanisms and therapeutic opportunities. Antioxid. Redox Signal. 9, 1959-1961 (2007).
11. Bisinotto F, Cardoso RP, Abud T. Acute pulmonary edema associated with obstruction of the airways. Case report. Rev. Bras. Anestesiol. 58, 165-171 (2008).
12. Bärtsch P, Mairbäurl H, Maggiorini M, Swenson E. Physiological aspects of high-altitude pulmonary edema. J. Appl. Physiol. 98, 1101-1110 (2005).
13. Hopkins S, Garg J, Bolar D, Balouch J, Levin D. Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema. Am. J. Respir. Crit. Care Med. 171, 83-87 (2005).
14. Knowles M, Carson J, Collier A, Gatzy J, Boucher R. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am. Rev. Respir. Dis. 124, 484-490 (1981).
15. +-dependent fluid reabsorption.
16. Sartori C, Duplain H, Lepori M et al. High altitude impairs nasal transepithelial sodium transport in HAPE-prone subjects. Eur. Respir. J. 23, 916-920 (2004).
17. Sartori C, Allemann Y, Scherrer U. Pathogenesis of pulmonary edema: learning from high-altitude pulmonary edema. Respir. Physiol. Neurobiol. 159, 338-349 (2007).
18. 2 generation by alveolar macrophages. Free Radic. Biol. Med. 32, 1304-1313 (2002).
19. Iles K, Forman H. Macrophage signaling and respiratory burst. Immunol. Res. 26, 95-105 (2002).
20. Parola M, Robino G, Marra F et al. HNE interacts with JNK isoforms in human hepatice stellate cells. J. Clin. Invest. 102, 1942-1950 (1998).
21. Punjabi C, Laskin J, Pendino K, Goller N, Durham S, Laskin D. Production of nitric oxide by rat type II pneumocytes: increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant. Am. J. Respir. Cell Mol. Biol. 11, 165-172 (1994).
22. Haddad I, Hu P, Galliani C, Beckman J, Matalon S. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. J. Clin. Invest. 94, 2407-2413 (1994). • Determined that excessive nitration is present in frozen lung sections from pediatric patients who had died from acute lung injury, consistent with the presence of nitrating species generated either by peroxynitrite, or from the myloperoxidase-catalyzed reaction of nitrite and hydrogen peroxidase. Excessive nitration was also found in the lungs of rats exposed to hyperoxia.
23. Kobayashi A, Hashimoto S, Kooguchi K et al. Expression of inducible nitric oxide synthase and inflammatory cytokines in alveolar macrophages of ARDS following sepsis. Chest 113, 1632-1639 (1998).
24. Sittipunt C, Steinberg K, Ruzinski J et al. Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 163, 503-510 (2001).
25. Ignarro L. Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism. Biochem. Soc. Trans. 20, 465-469 (1992).
26. Stamler J, Simon D, Jaraki O et al. S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme. Proc. Natl Acad. Sci. USA 89, 8087-8091 (2009).
27. Guo C, Atochina-Vasserman E, Abramova E et al. S-nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biol. 6, e266 (2008).
28. Marshall H, Potts E, Kelleher Z, Stamler J, Foster W, Auten R. Protection from LPS-induced lung injury by augmentation of airway S-nitrosothiols. Am. J. Respir. Crit. Care Med. 180(1), 11-18 (2009).
29. Beckman J, Beckman T, Chen J, Marshall P, Freeman B. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl Acad. Sci. USA 87, 1620-1624 (1990).
30. Hu P, Ischiropoulos H, Beckman J, Matalon S. Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells. Am. J. Physiol. 266, L628-L634 (1994).
31. van der Vliet A, Hoen P, Wong P, Bast A, Cross C. Formation of S-nitrosothiols via direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide. J. Biol. Chem. 273, 30255-30262 (1998).
32. Hickman-Davis J, McNicholas-Bevensee C, Davis I et al. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am. J. Respir. Crit. Care Med. 173, 334-344 (2006).
33. Lazrak A, Iles K, Liu G, Noah D, Noah J, Matalon S. Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J. (2009) (Epub ahead of print).
34. Wang H, Zentner M, Deng H et al. Oxidative stress disrupts glucocorticoid hormone-dependent transcription of the amiloride-sensitive epithelial sodium channel α-subunit in lung epithelial cells through ERK-dependent and thioredoxin-sensitive pathways. J. Biol. Chem. 24, 8600-8609 (2000).
35. + ions across lung epithelial cells creates an osmotic force leading to the reabsorption of edema fluid. Consistent with this, patients with acute respiratory distress syndrome who could concentrate proteins in their edema fluid had a better outcome (mortality and oxygenation) than those who could not. This study provided the first evidence for the importance of active sodium transport in lung fluid balance across the lungs of patients with severe lung injury.
36. Ware L, Matthay M. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 163, 1376-1383 (2001).
37. Yue G, Matalon S. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats. Am. J. Physiol. 272, L407-L412 (1997).
38. +-ATPase activity by β-adrenergic agonist in alveolar type II cells. Am. J. Physiol. 268, L983-L990, 1995.
39. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay M. Alveolar fluid clearance in the resected human lung. Am. J. Respir. Crit. Care Med. 150, 305-310 (1994).
40. Pittet J, Lu L, Morris D et al. Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. J. Immunol. 166, 6301-6310 (2001).
41. Zhu S, Ware L, Geiser T, Matthay M, Matalon S. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Am. J. Respir. Crit. Care Med. 163, 166-172 (2001).
42. + currents in Xenopus oocytes expressing αβγ-rENaC. Am. J. Physiol. 274, C1417-C1423 (1998).
43. Matalon S, Beckman J, Duffey M, Freeman B. Oxidant inhibition of epithelial active sodium transport. Free Radic. Biol. Med. 6, 557-564 (1989).
44. Vadász I, Morty R, Kohstall M et al. Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 171, 469-479 (2005).
45. +-ATPase. Am. J. Respir. Cell Mol. Biol. 33, 343-354 (2005).
46. Yucel O, Kunak Z, Macit E et al. Protective efficiacy of taurine against pulmonary edema progression: experimental study. J. Cardiothorac. Surg. 3, 57 (2008).
47. Sivrikoz M, Tunçözgür B, Cekmen M et al. The role of tissue reperfusion in the reexpansion injury of the lungs. Eur. J. Cardiothorac. Surg. 22, 721-727 (2002).
48. Tibor B, Zsolt R. High altitude and free radicals. J. Sports Sci. Med. 3, 64-69 (2009).
49. Sarada S, Himadri P, Mishra C, Geetali P, Ram M, Ilavazhagan G. Role of oxidative stress and NFκB in hypoxia-induced pulmonary edema. Exp. Biol. Med. (Maywood) 233, 1088-1098 (2008).
50. Dickinson DA, Liu RM, Iles KE, Forman HF. Signaling for the synthesis of glutathione. In: Free Radicals in Chemistry, Biology and Medicine. Yoshikawa T (Ed.). OICA International, London, UK (2000).
51. Iles K, Liu R. Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. J. Free Radic. Biol. Med. 38, 547-556 (2005).
52. Dickinson DA, Forman HJ. Glutathione in defense and signaling: lessons from a small thiol. Ann. NY Acad. Sci. 973, 488-504 (2002).
53. Wild AC, Gipp JJ, Mulcahy T. Overlapping antioxidant response element and PMA response element sequences mediate basal and β-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase catalytic subunit gene. Biochem. J. 332, 373-381 (1998).
54. Fu Z, Jiang P, Ren Y et al. Changes of antioxidative capacity and endothelial function before and after treatment among patients with high altitude pulmonary edema. Zhonghua Jie He He Hu Xi Za Zhi 25, 33-35 (2002).
55. Vats P, Singh V, Singh S, Singh S. Glutathione metabolism under high-altitude stress and effect of antioxidant supplementation. Aviat. Space Environ. Med. 79, 1106-1111 (2008).
56. Sciuto A, Cascio M, Moran T, Forster J. The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7 days in mice with acute lung injury. Inhal. Toxicol. 15, 675-685 (2003).
57. Dickinson D, Iles K, Watanabe N et al. 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. Free Radic. Biol. Med. 33, 974-987 (2002).
58. Dickinson D, Iles K, Zhang H, Blank V, Forman H. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J. 17, 473-475 (2003). • Definitively showed that curcumin could simultaneously modulate key cell signaling pathways to robustly enhance the de novo production of the antioxidant glutathione. It was demonstrated that curcumin could remodel transcription factor complexes and alter activation and translocation to signal for the upregulation of protective genes. This established a molecular rationale for using diet to increase the production of GSH in lung epithelia, which may have applications in reducing the severity of NPE, or delaying or preventing its onset.
59. Guidot D, Modelska K, Lois M et al. Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats. Am. J. Physiol. Lung Cell Mol. Physiol. 279, L127-L135 (2000).