Heat shock protein 27 enhances the inhibitory effect of influenza A virus NS1 on the expression of interferon-β

Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology

Volumn 28, Issue 10, 2012, Pages 1205-1215

  Li, Zheng ^a,b   Liu, Xiaoling ^a   Zhao, Zhendong ^a,b   Liu, Wenjun ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Heat shock protein 27; Interaction; Interferon ; NS1 protein

Indexed keywords

BETA INTERFERON; HEAT SHOCK PROTEIN 27; INS1 PROTEIN, INFLUENZA VIRUS; VIRUS PROTEIN;

ARTICLE; CELL LINE; CELL STRAIN HEK293; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA; METABOLISM;

CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INFLUENZA, HUMAN; INTERFERON-BETA; VIRAL NONSTRUCTURAL PROTEINS;

EUKARYOTA; INFLUENZA A VIRUS; INFLUENZAVIRUS A; ORTHOMYXOVIRIDAE; PROKARYOTA;

EID: 84870613026     PISSN: 10003061     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Whittaker GR. Intracellular trafficking of influenza virus: clinical implications for molecular medicine. Expert Rev Mol Med, 2001, 2001: 1-13.
2. Chen WS, Calvo PA, Malide D, et al. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med, 2001, 7(12): 1306-1312.
3. Wise HM, Foeglein A, Sun JC, et al. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J Virol, 2009, 83(16): 8021-8031.
4. Fukuyama S, Kawaoka Y. The pathogenesis of influenza virus infections: the contributions of virus and host factors. Curr Opin Immunol, 2011, 23(4): 481-486.
5. Nemeroff ME, Barabino SML, Li YZ, et al. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell, 1998, 1(7): 991-1000.
6. Chen ZY, Li YZ, Krug RM. Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J, 1999, 18(8): 2273-2283.
7. Qiu Y, Krug RM. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J Virol, 1994, 68(4): 2425-2432.
8. Fortes P, Beloso A, Ortín J. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J, 1994, 13(3): 704-712.
9. de la Luna S, Fortes P, Beloso A, et al. Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J Virol, 1995, 69(4): 2427-2433.
10. Burgui I, Aragón T, Ortín J, et al. PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. J Gen Virol, 2003, 84(Pt 12): 3263-3274.
11. Hale BG, Randall R E, Ortín J, et al. The multifunctional NS1 protein of influenza A viruses. J Gen Virol, 2008, 89(Pt 10): 2359-2376.
12. Mibayashi M, Martínez-Sobrido L, Loo YM, et al. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol, 2007, 81(2): 514-524.
13. Opitz B, Rejaibi A, Dauber B, et al. IFNβ induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol, 2007, 9(4): 930-938.
14. Kochs G, García-Sastre A, Martínez-Sobrido L. Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol, 2007, 81(13): 7011-7021.
15. Arrigo AP. The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis. Adv Exp Med Biol, 2007, 594: 14-26.
16. Kostenko S, Moens U. Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology. Cell Mol Life Sci, 2009, 66(20): 3289-3307.
17. Welsh MJ, Gaestel M. Small heat-shock protein family: function in health and disease. Ann N Y Acad Sci, 1998, 851: 28-35.
18. Kostenko S, Johannessen M, Moens U. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Cell Signal, 2009, 21(5): 712-718.
19. Matsushima-Nishiwaki R, Takai S, Adachi S, et al. Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase. J Biol Chem, 2008, 283(27): 18852-18860.
20. Wu R, Kausar H, Johnson P, et al. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J Biol Chem, 2007, 282(30): 21598-21608.
21. Shaw ML, Stone KL, Colangelo CM, et al. Cellular proteins in influenza virus particles. PLoS Pathog, 2008, 4(6): e1000085.
22. Liu N, Song WJ, Wang P, et al. Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells. Proteomics, 2008, 8(9): 1851-1858.
23. Suomalainen M, Nakano MY, Boucke K, et al. Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus. EMBO J, 2001, 20(6): 1310-1319.
24. Singh D, McCann K L, Imani F. MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption. Am J Physiol Lung Cell Mol Physiol, 2007, 293(2): L436-L445.
25. Mathew S S, Della Selva M, Burch A D. Modification and reorganization of the cytoprotective cellular chaperone Hsp27 during herpes simplex virus type 1 infection. J Virol, 2009, 83(18): 9304-9312.
26. Liang D, Benko Z, Agbottah E, et al. Anti-vpr activities of heat shock protein 27. Mol Med, 2007, 13(5/6): 229-239.
27. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol, 2008, 20(1): 17-22.