In vivo detection of intermediate metabolic products of [1- 13C]ethanol in the brain using 13C MRS

NMR in Biomedicine

Volumn 24, Issue 9, 2011, Pages 1054-1062

  Xiang, Yun ^a   Shen, Jun ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Acetate; Cerebral metabolism; Ethanol; In vivo 13C MRS

Indexed keywords

ACETATE; ASPARTATES; BRAIN METABOLISM; BRAIN METABOLITES; BRAIN TISSUE; CEREBRAL METABOLISM; D-GLUCOSE; IN VIVO 13C MRS; IN-VIVO; INTRAGASTRIC ADMINISTRATION; INTRAVENOUS ADMINISTRATION; J COUPLING; METABOLIC PRODUCTS; PUBLIC DOMAINS; RAT BRAIN; SIGNAL AVERAGING; SIGNAL INTENSITIES; SIMULTANEOUS DETECTION; SPECTRAL REGION; TIME COURSE;

ALDEHYDES; AMIDES; AMINO ACIDS; BIOMOLECULES; ETHANOL; GLUCOSE; METABOLISM; METABOLITES; PHYSIOLOGY; RATS; SIGNAL DETECTION; TISSUE; VOLATILE FATTY ACIDS;

BRAIN;

ACETALDEHYDE; ALCOHOL; AMIDE; ASPARTIC ACID; BICARBONATE; CARBON 13; CARBOXYLIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE;

ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; BRAIN TISSUE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CONTROLLED STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL DETECTION;

ANIMALS; BRAIN; CARBON ISOTOPES; ETHANOL; GLUCOSE; INFUSIONS, INTRAVENOUS; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC NETWORKS AND PATHWAYS; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; TIME FACTORS;

RATTUS;

EID: 80054065714     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1653     Document Type: Article

References (54)

1. Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, Kalant H, Koob GF, Li TK, Tabakoff B. Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin. Exp. Res. 1998; 22: 998-1040.
2. Mukherji B, Kashiki Y, Ohyanagi H, Sloviter HA. Metabolism of ethanol and acetaldehyde by the isolated perfused rat brain. J. Neurochem. 1975; 24: 841-843.
3. Deng XS, Deitrich RA. Putative role of brain acetaldehyde in ethanol addiction. Curr. Drug Abuse Rev. 2008; 1: 3-8.
4. Lutwak-Mann C. Alcohol dehydrogenase of animal tissues. Biochem. J. 1938; 32: 1364-1374.
5. Towne JC. Effect of ethanol and acetaldehyde on liver and brain monoamine oxidase. Nature, 1964; 201: 709-710.
6. Deitrich R, Zimatkin S, Pronko S. Oxidation of ethanol in the brain and its consequences. Alcohol Res. Health. 2006; 29: 266-273.
7. Westcott JY, Weiner H, Shultz J, Myers RD. In vivo acetaldehyde in the brain of the rat treated with ethanol. Biochem. Pharmacol. 1980; 29: 411-417.
8. Petersen DR. Aldehyde dehydrogenase and aldehyde reductase in isolated bovine brain microvessels. Alcohol, 1985; 2: 79-83.
9. Tampier L, Cariz S, Quintanilla ME. Metabolism of acetaldehyde by rat isolated aortic rings: does endothelial tissue contribute to its extrahepatic metabolism? Alcohol, 1993; 10: 203-206.
10. Tampier L, Quintanilla ME, Letelier C, Mardones J. Effect of 3-amino-1, 2, 4-triazole on narcosis time and lethality of ethanol in UChA rats. Alcohol, 1988; 5: 5-8.
11. 2 system. Biochem. Pharmacol. 1992; 44: 93-98.
12. Gill K, Menez JF, Lucas D, Deitrich RA. Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol Clin. Exp. Res. 1992; 16: 910-915.
13. Zimatkin SM, Buben AL. Ethanol oxidation in the living brain. Alcohol Alcoholism, 2007; 42: 529-532.
14. 14C]ethanol into the glutamate-glutamine pools of rat brain in vivo. Biochem. J. 1972; 126: 467-469.
15. 11C ethanol with PET in eight patients with hepatocellular carcinomas who were scheduled for treatment with precutaneous ethanol injection. Radiology, 1999; 211: 681-686.
16. 13C NMR spectroscopy. Neurochem. Int. 2004; 45: 297-303.
17. Yang J, Shen J. Elevated endogenous GABA concentration attenuates glutamate-glutamine cycling between neurons and astroglia. J. Neural. Transm. 2009; 116: 291-300.
18. 13C]glucose infusion and low-power stochastic decoupling. Magn. Reson. Med. 2009; 62: 565-573.
19. 13C NMR. J. Biol. Chem. 1990; 265: 12916-12926.
20. 13C NMR. Proc. Natl. Acad. Sci. USA, 1999; 96: 8235-8240.
21. Shulman RG, Rothman DL. Brain Energetics and Neuronal Activity. Chichester, John Wiley & Sons: 2004.
22. 13C-MRS analysis. Dev. Neurosci. 1996; 18: 434-442.
23. 13C-MRS to research on brain metabolism. NMR Biomed. 2003; 16: 303-312.
24. 13C NMR spectroscopic study. J. Neurochem. 1995; 64: 2773-2782.
25. 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J. Neurosci. 2002; 22: 1523-1531.
26. 13C MR spectra acquired from human brain in vivo. J. Magn. Reson. 2003; 162: 259-268.
27. 13C]acetate. Neurochem. Int. 2007; 50: 371-378.
28. 13C MRS of rhesus monkey brain. NMR Biomed. 2005; 18: 560-569.
29. Mayfield ED, Bensadoun A, Johnson BC. Acetate metabolism in ruminant tissues. J. Nutr. 1966; 89: 189-196.
30. Mendelson JH, Woods BT, Chiu TM, Mello NK, Lukas SE, Teoh SK, Sintavanarong P, Cochin J, Hopkins MA, Dobrosielski M. In vivo proton magnetic resonance spectroscopy of alcohol in human brain. Alcohol, 1990; 7: 443-447.
31. 13C saturation transfer effect of the lactate dehydrogenase reaction. Magn. Reson. Med. 2007; 57: 258-264.
32. 13C saturation transfer effect of carbon dioxide-bicarbonate exchange catalyzed by carbonic anhydrase in vivo. Magn. Reson. Med. 2008; 59: 492-498.
33. 13C magnetization transfer spectroscopy. J. Cereb. Blood Flow Metab. 2009; 29: 661-669.
34. Li S, Shen J. Integrated RF probe for in vivo multinuclear spectroscopy and functional imaging of rat brain using an 11.7 Tesla 89mm bore vertical microimager. MAGMA, 2005; 18: 119-127.
35. 13C]glucose. J. Magn. Reson. 2006; 182: 221-228.
36. Chen Z, Li SS, Yang J, Letizia D, Shen J. Measurement and automatic correction of high-order B0 inhomogeneity in the rat brain at 11.7 Tesla. Magn. Reson. Imaging, 2004; 22: 835-842.
37. 1H-NMR spectroscopy. Int. J. Biochem. 1985; 17: 471-478.
38. 13C decoupling with the reverse DEPT polarization-transfer pulse sequence. Biochem. Biophys. Res. Commun. 1985; 128: 107-112.
39. San George RC, Hoberman HD. Reaction of acetaldehyde with hemoglobin. J. Biol. Chem. 1986; 261: 6811-6821.
40. Sheridan RP, Deakyne CA, Allen LC. Acetaldehyde hydrate and carbonic anhydrase: possible roles in the inhibition of brain aldehyde dehydrogenase. Adv. Exp. Med. Biol. 1980; 132: 705-713.
41. 13C MRS using very low RF power for proton decoupling. Magn. Reson. Med. 2007; 57: 265-271.
42. 13C]GABA C1. J. Neurosci. Methods, 2009; 182: 236-243.
43. Mason GF, Falk Petersen K, de Graaf RA, Kanamatsu T, Otsuki T, Shulman GI, Rothman DL. A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose. Brain Res. Brain Res. Protoc. 2003; 10: 181-190.
44. Selmer J, Grunnet N. Ethanol metabolism and lipid synthesis by isolated liver cells from fed rats. Biochim. Biophys. Acta, 1976; 428: 123-137.
45. Kilanmaa K, Virtanen P. Ethanol and acetaldehyde levels in cerebrospinal fluid during ethanol oxidation in the rat. Neurosci. Lett. 1978; 10: 181-186.
46. Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I. Catalase mediates acetaldehyde formation in the striatum of free-moving rats. Neurotoxicology, 2007; 28: 1245-1248.
47. Lundquist F. Production and utilization of free acetate in man. Nature, 1962; 4815: 579-580.
48. Lundquist F, Tygstrup N, Winkler K, Mellemgaard K, Munck-Petersen S. Ethanol metabolism and production of free acetate in the human liver. J. Clin. Invest. 1962; 41: 955-961.
49. Crabb DW, Bosron WF, Li TK. Ethanol metabolism. Pharm. Ther. 1987; 34: 59-73.
50. Xu S, Shen J. Studying enzymes by in vivo C magnetic resonance spectroscopy. Prog. Nucl. Magn. Reson. Spectrosc. 2009; 55: 266-283.
51. 13C-magnetic resonance spectroscopy to studies of neuronal/glial relationships. Dev. Neurosci. 1998; 20: 277-288.
52. 13C MRS study of brain metabolism. ISMRM-ESMRMB 2010 Joint Annual Conference. MRS of Animal Brain, Stockholm, Sweden, 2010; 2384.
53. 13C MRS at 11.7 Tesla. ISMRM-ESMRMB 2010 Joint Annual Conference. MRS of Animal Brain, Stockholm, Sweden, 2010; 2383.
54. 1H NMR-based metabolic analysis of liver, serum, and brain following ethanol administration in rats. Chem. Res. Toxicol. 2008; 21: 408-420.