Hydrogen Sulfide Suppresses Outward Rectifier Potassium Currents in Human Pluripotent Stem Cell-Derived Cardiomyocytes

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Wei, Heming ^a,b   Zhang, Guangqin ^a   Qiu, Suhua ^a   Lu, Jun ^a   Sheng, Jingwei ^a   Manasi, ^a   Tan, Grace ^a   Wong, Philip ^a,b   Gan, Shu Uin ^c   Shim, Winston ^a,b  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; HYDROGEN SULFIDE; OUTWARD RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL FUNCTION; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYONIC STEM CELL; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MOLECULAR IMAGING; MOLECULAR INTERACTION; PATCH CLAMP; PLURIPOTENT STEM CELL;

ACTION POTENTIALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL DIFFERENTIATION; ELECTRIC CONDUCTIVITY; EMBRYONIC STEM CELLS; HEART ATRIA; HEART VENTRICLES; HUMANS; HYDROGEN SULFIDE; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS;

EID: 84870583721     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050641     Document Type: Article

References (26)

1. Roy M, Dumaine R, Brown AM, (1996) HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation 94: 817-823.
2. Cavero I, Mestre M, Guillon JM, Crumb W, (2000) Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias. Expert Opin Pharmacother 1: 947-973.
3. Braam SR, Mummery CL, (2010) Human stem cell models for predictive cardiac safety pharmacology. Stem Cell Res 4: 155-156.
4. Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, et al. (2001) Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 108: 407-414.
5. Zhang J, Wilson GF, Soerens AG, Koonce CH, Yu J, et al. (2009) Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 104: e30-41.
6. Szabo C, (2007) Hydrogen sulphide and its therapeutic potential. Nature reviews Drug discovery 6: 917-935.
7. Tang G, Wu L, Wang R, (2010) Interaction of hydrogen sulfide with ion channels. Clin Exp Pharmacol Physiol 37: 753-763.
8. Graichen R, Xu X, Braam SR, Balakrishnan T, Norfiza S, et al. (2008) Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 76: 357-370.
9. Maltsev VA, Wobus AM, Rohwedel J, Bader M, Hescheler J, (1994) Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res 75: 233-244.
10. Ma J, Guo L, Fiene SJ, Anson BD, Thomson JA, et al. (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol 301: H2006-2017.
11. Wei H, Tan G, Manasi, Qiu S, Kong G, et al. (2012) One-step derivation of cardiomyocytes and mesenchymal stem cells from human pluripotent stem cells. Stem Cell Res 9: 87-100.
12. Cheng H, Song LS, Shirokova N, Gonzalez A, Lakatta EG, et al. (1999) Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method. Biophys J 76: 606-617.
13. Xu XQ, Graichen R, Soo SY, Balakrishnan T, Rahmat SN, et al. (2008) Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation 76: 958-970.
14. Reiffenstein RJ, Hulbert WC, Roth SH, (1992) Toxicology of hydrogen sulfide. Annual review of pharmacology and toxicology 32: 109-134.
15. Wu R, Yao WZ, Chen YH, Geng B, Tang CS, (2008) [Plasma level of endogenous hydrogen sulfide in patients with acute asthma]. Beijing Da Xue Xue Bao 40: 505-508.
16. Chen YH, Yao WZ, Geng B, Ding YL, Lu M, et al. (2005) Endogenous hydrogen sulfide in patients with COPD. Chest 128: 3205-3211.
17. Cheng Y, Ndisang JF, Tang G, Cao K, Wang R, (2004) Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 287: H2316-2323.
18. Lavu M, Bhushan S, Lefer DJ, (2011) Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential. Clin Sci (Lond) 120: 219-229.
19. Li GR, Feng J, Yue L, Carrier M, Nattel S, (1996) Evidence for two components of delayed rectifier K+ current in human ventricular myocytes. Circ Res 78: 689-696.
20. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, et al. (2010) Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 363: 1397-1409.
21. Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, et al. (2011) Modelling the long QT syndrome with induced pluripotent stem cells. Nature 471: 225-229.
22. Sun YG, Cao YX, Wang WW, Ma SF, Yao T, et al. (2008) Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes. Cardiovasc Res 79: 632-641.
23. Roden DM, George AL Jr, (1996) The cardiac ion channels: relevance to management of arrhythmias. Annu Rev Med 47: 135-148.
24. Mustafa AK, Gadalla MM, Sen N, Kim S, Mu W, et al. (2009) H2S signals through protein S-sulfhydration. Sci Signal 2: ra72.
25. Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, et al. (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109: 1259-1268.
26. Zhong GZ, Li YB, Liu XL, Guo LS, Chen ML, et al. (2010) Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes. Cardiology 115: 120-126.