Human stem cell models for predictive cardiac safety pharmacology

Stem Cell Research

Volumn 4, Issue 3, 2010, Pages 155-156

  Braam, Stefan R ^a   Mummery, Christine L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL HERG;

CARDIOVASCULAR RISK; CELL CULTURE MONITORING; CELL MATURATION; DRUG SAFETY; EDITORIAL; ELECTROCARDIOGRAM; EMBRYONIC STEM CELL; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE TACHYCARDIA; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; LIGAND BINDING; NONHUMAN; PATCH CLAMP; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; TARGET ORGAN; TORSADE DES POINTES;

ACTION POTENTIALS; ELECTROCARDIOGRAPHY; EMBRYONIC STEM CELLS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; TORSADES DE POINTES; TOXICITY TESTS;

EID: 77952250654     PISSN: 18735061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scr.2010.04.008     Document Type: Editorial

References (5)

1. Braam S.R., Tertoolen L., van de Stolpe A., Meyer T., Passier R., and Mummery C.L. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Research 4 (2010) 107-116
2. Jonsson M.K.B., Duker G., Tropp C., Andersson B., Sartipy P., Vos M.A., and Van Veen T.A.B. Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes. Stem Cell Research 4 (2010) 189-200
3. Otsuji T.G., Minami I., Kurose Y., Yamauchi K., Tada M., and Nakatsuji N. Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Research 4 (2010) 201-213
4. Pugsley M.K., Authier S., and Curtis M.J. Principles of safety pharmacology. Br J Pharmacol 154 (2008) 1382-1399
5. Shah R.R., and Hondeghem L.M. Refining detection of drug-induced proarrhythmia: QT interval and TRIaD. Heart rhythm: the official journal of the Heart Rhythm Society 2 (2005) 758-772