DAMTC regulates cytoskeletal reorganization and cell motility in human lung adenocarcinoma cell line: An integrated proteomics and transcriptomics approach

Cell Death and Disease

Volumn 3, Issue 10, 2012, Pages

  Goel, A ^a   Chhabra, R ^a   Ahmad, S ^a   Prasad, A K ^b   Parmar, V S ^b   Ghosh, B ^a   Saini, N ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Apoptosis; Cytoskeletal reorganization; DAMTC; Rho family GTPase; RhoGDI

Indexed keywords

7,8 DIACETOXY 4 METHYLCOUMARIN; COUMARIN DERIVATIVE; ETOPOSIDE; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; PROTEIN P53; RAC1 PROTEIN; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CELL MOTILITY; CONTROLLED STUDY; FILOPODIUM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMICS; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; WESTERN BLOTTING;

ACTINS; ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; COUMARINS; CYTOSKELETON; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; ONCOGENE PROTEINS; PROTEOMICS; RHO GTP-BINDING PROTEINS; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR ALPHA; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84870574183     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.141     Document Type: Article

References (48)

1. Spiro SG, Silvestri GA. One hundred years of lung cancer. Am J Respir Crit Care Med 2005; 172: 523-529.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T et al. Cancer statistics, 2008. CA Cancer J Clin 2008; 58: 71-96.
3. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008; 359: 1367-1380.
4. Carnero A. Targeting the cell cycle for cancer therapy. Br J Cancer 2002; 87: 129-133.
5. Chang GC, Chen KC, Yang TY, Yin MC, Lin CP, Kuo BI et al. Activity of gefitinib in advanced non-small-cell lung cancer with very poor performance status. Invest New Drugs 2005; 23: 73-77.
6. Wright G, Manser RL, Byrnes G, Hart D, Campbell DA. Surgery for non-small cell lung cancer: systematic review and meta-analysis of randomised controlled trials. Thorax 2006; 61: 597-603.
7. Goel A, Prasad AK, Parmar VS, Ghosh B, Saini N. Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway. Chem Biol Interact 2009; 179: 363-374.
8. Wang Y, Barbacioru C, Hyland F, Xiao W, Hunkapiller KL, Blake J et al. Large scale realtime PCR validation on gene expression measurements from two commercial longoligonucleotide microarrays. BMC Genomics 2006; 7: 59.
9. Kim CS, Sohn SH, Jeon SK, Kim KN, Ryu JJ, Kim MK. Effect of various implant coatings on biological responses in MG63 using cDNA microarray. J Oral Rehabil 2006; 33: 368-379.
10. Smith L, Lind MJ, Welham KJ, Cawkwell L. Cancer proteomics and its application to discovery of therapy response markers in human cancer. Cancer 2006; 107: 232-241.
11. Chan E. Integrating transcriptomics and proteomics. Genom Proteom 2006; 6: 20-26.
12. Parri M, P Chiarugi. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal 2010; 8: 23.
13. Olson MF, Sahai E. The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis 2009; 26: 273-287.
14. MacKeigan JP, Clements CM, Lich JD, Pope RM, Hod Y, Ting JP. Proteomic profiling druginduced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIαlpha. Cancer Res 2003; 63: 6928-6934.
15. Zhang B, Zhang Y, Dagher MC, Shacter E. Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis. Cancer Res 2005; 65: 6054-6062.
16. Zhao L, Wang H, Li J, Liu Y, Ding Y. Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer. J Proteome Res 2008; 7: 3994-4003.
17. Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998; 31: 152-161.
18. Park YJ, Ahn HJ, Kim YS, Cho Y, Joo DJ, Ju MK. Illumina-microarray analysis of mycophenolic acid-induced cell death in an insulin-producing cell line and primary rat islet cells: new insights into apoptotic pathways involved. Cell Signal 2010; 22: 1773-1782.
19. Qu MJ, Liu B, Qi YX, Jiang ZL. Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain. Ann Biomed Eng 2008; 36: 1481-1488.
20. Garcia-Mata R, Boulter E, Burridge K. The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol 2011; 12: 493-504.
21. Dovas A, Couchman Jr. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 2005; 390: 1-9.
22. Kamai T, Yamanishi T, Shirataki H, Takagi K, Asami H, Ito Y et al. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 2004; 10: 4799-4805.
23. Bohil AB, Robertson BW, Cheney RE. Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci USA 2006; 103: 12411-12416.
24. Goh WI, Sudhaharan T, Lim KB, Sem KP, Lau CL, Ahmed S. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors. J Biol Chem 2011; 286: 13681-13694.
25. Korobova F, Svitkina T. Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Mol Biol Cell 2008; 19: 1561-1574.
26. Kuzelova K, Grebenova D, Pluskalova M, Kavan D, Halada P, Hrkal Z. Isoform-specific cleavage of 14-3-3 proteins in apoptotic JURL-MK1 cells. J Cell Biochem 2009; 106: 673-681.
27. Brouillard F, Fritsch J, Edelman A, Ollero M. Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology. Proteom Clin Appl 2008; 2: 264-285.
28. Zhang DH, Tai LK, Wong LL, Sethi SK, Koay ES. Proteomics of breast cancer: enhanced expression of cytokeratin19 in human epidermal growth factor receptor type 2 positive breast tumors. Proteomics 2005; 5: 1797-1805.
29. Oshima RG, Baribault H, Caulin C. Oncogenic regulation and function of keratins 8 and 18. Cancer Metastasis Rev 1996; 15: 445-471.
30. Chang GC, Liu KJ, Hsieh CL, Hu TS, Charoenfuprasert S, Liu HK et al. Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes. Clin Cancer Res 2006; 12: 5746-5754.
31. Tsai ST, Chien IH, Shen WH, Kuo YZ, Jin YT, Wong TY et al. ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction. Eur J Cancer 2010; 46: 1712-1723.
32. Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 2005; 15: 300-308.
33. Chen G, Gharib TG, Wang H, Huang CC, Kuick R, Thomas DG et al. Protein profiles associated with survival in lung adenocarcinoma. Proc Natl Acad Sci USA 2003; 100: 13537-13542.
34. Li C, Xiao Z, Chen Z, Zhang X, Li J, Wu X et al. Proteome analysis of human lung squamous carcinoma. Proteomics 2006; 6: 547-558.
35. Chen Y, Zhang H, Xu A, Li N, Liu J, Liu C et al. Elevation of serum l-lactate dehydrogenase B correlated with the clinical stage of lung cancer. Lung Cancer 2006; 54: 95-102.
36. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM et al. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 1997; 231: 509-513.
37. Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC et al. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005; 7: 263-273.
38. Hod Y. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J Cell Biochem 2004; 92: 1221-1233.
39. Gu L, Cui T, Fan C, Zhao H, Zhao C, Lu L et al. Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress. Biochem Biophys Res Commun 2009; 383: 469-474.
40. He X, Zheng Z, Li J, Ben Q, Liu J, Zhang J et al. DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. Carcinogenesis 2012; 33: 555-562.
41. Kumar S, Singh BK, Kalra N, Kumar V, Kumar A, Prasad AK et al. Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation. Bioorg Med Chem 2005; 13: 1605-1613.
42. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30: 207-210.
43. Chhabra R, Dubey R, Saini N. Gene expression profiling indicate role of ER stress in miR-23a∼27a∼24-2 cluster induced apoptosis in HEK293T cells. RNA Biol 2011; 8: 648-664.
44. Dubey R, Chhabra R, Saini N. Small interfering RNA against transcription factor STAT6 leads to increased cholesterol synthesis in lung cancer cell lines. PLoS One 2011; 6: e28509.
45. Nogales-Cadenas R, Carmona-Saez P, Vazquez M, Vicente C, Yang X, Tirado F et al. GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Res 2009; 37(Web Server issue): W317-W322.
46. Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano A. GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol 2007; 8: R3.
47. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
48. Goel A, Prasad AK, Parmar VS, Ghosh B, Saini N. 7,8-Dihydroxy-4- methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK/MAPK signaling. FEBS Lett 2007; 581: 2447-2454.