ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Lu, W ^a   Chen, Z ^a,c   Zhang, H ^a   Wang, Y ^a   Luo, Y ^b   Huang, P ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cisplatin; GPX1; Mitochondrial dysfunction; ROS; ZNF143

Indexed keywords

CISPLATIN; DNA POLYMERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; MITOCHONDRIAL TRANSCRIPTION FACTOR A; SELENOCYSTEINE; TRANSCRIPTION FACTOR; TRANSFER RNA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 143;

ARTICLE; CELL ACTIVITY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY FAILURE; RNA SYNTHESIS; UPREGULATION;

CELL LINE; CELL RESPIRATION; CELL SURVIVAL; DNA-DIRECTED DNA POLYMERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; MITOCHONDRIA; OXIDATIVE STRESS; OXYGEN; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84870559589     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.156     Document Type: Article

References (29)

1. Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci USA 2005; 102: 719-724.
2. DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K et al. Oncogeneinduced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011; 475: 106-109.
3. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 2003; 57: 145-155.
4. Shen Q, Chu FF, Newburger PE. Sequences in the 30-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem 1993; 268: 11463-11469.
5. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011; 15: 1957-1997.
6. Esworthy RS, Ho YS, Chu FF. The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch Biochem Biophys 1997; 340: 59-63.
7. Legault J, Carrier C, Petrov P, Renard P, Remacle J, Mirault ME. Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells. Biochem Biophys Res Commun 2000; 272: 416-422.
8. Chambers I, Frampton J, Goldfarb P, Affara N, McBain W, Harrison PR. The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J 1986; 5: 1221-1227.
9. Wakasugi T, Izumi H, Uchiumi T, Suzuki H, Arao T, Nishio K et al. ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes. Oncogene 2007; 26: 5194-5203.
10. Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E et al. Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cellcycle- associated genes. Cancer Sci 2010; 101: 2538-2545.
11. Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F et al. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol 2012; 10: e1001326.
12. Jazayeri M, Andreyev A, Will Y, Ward M, Anderson CM, Clevenger W. Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype. J Biol Chem 2003; 278: 9823-9830.
13. Spelbrink JN, Toivonen JM, Hakkaart GA, Kurkela JM, Cooper HM, Lehtinen SK et al. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells. J Biol Chem 2000; 275: 24818-24828.
14. Flohe L, Gunzler WA, Schock HH. Glutathione peroxidase: a selenoenzyme. FEBS Lett 1973; 32: 132-134.
15. Schuster C, Myslinski E, Krol A, Carbon P. Staf, a novel zinc finger protein that activates the RNA polymerase III promoter of the selenocysteine tRNA gene. EMBO J 1995; 14: 3777-3787.
16. Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M. The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science 2009; 325: 321-325.
17. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 2005; 65: 613-621.
18. Gerard MA, Krol A, Carbon P. Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene. Gene 2007; 401: 145-153.
19. Garrido N, Griparic L, Jokitalo E, Wartiovaara J, van der Bliek AM, Spelbrink JN. Composition and dynamics of human mitochondrial nucleoids. Mol Biol Cell 2003; 14: 1583-1596.
20. Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H et al. ROSgenerating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008; 320: 661-664.
21. Brandon M, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene 2006; 25: 4647-4662.
22. Uchiumi T, Knag D. Cisplatin sensitivity transcriptional factor and mitochondrial DNA maintenance protein. Rinsho Byori 2009; 57: 978-986.
23. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003; 22: 7265-7279.
24. Rudin CM, Yang Z, Schumaker LM, VanderWeele DJ, Newkirk K, Egorin MJ et al. Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res 2003; 63: 312-318.
25. Montopoli M, Bellanda M, Lonardoni F, Ragazzi E, Dorigo P, Froldi G et al. 'Metabolic reprogramming' in ovarian cancer cells resistant to cisplatin. Curr Cancer Drug Targets 2011; 11: 226-235.
26. Lu W, Luo Y, Kan M, McKeehan WL. Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. J Biol Chem 1999; 274: 12827-12834.
27. Carew JS, Nawrocki ST, Xu RH, Dunner K, McConkey DJ, Wierda WG et al. Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine. Leukemia 2004; 18: 1934-1940.
28. Mahata B, Mukherjee S, Mishra S, Bandyopadhyay A, Adhya S. Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells. Science 2006; 314: 471-474.
29. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006; 10: 241-252.