The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model

Journal of Investigative Dermatology

Volumn 132, Issue 12, 2012, Pages 2744-2751

  Lehtimäki, Sari ^a   Savinko, Terhi ^a   Lahl, Katharina ^b   Sparwasser, Tim ^c   Wolff, Henrik ^a   Lauerma, Antti ^d   Alenius, Harri ^a   Fyhrquist, Nanna ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DIPHTHERIA TOXIN; OXAZOLONE; TRANSCRIPTION FACTOR FOXP3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTACT ALLERGY; CONTROLLED STUDY; EFFECTOR CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SENSITIZATION; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

EID: 84870559347     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.212     Document Type: Article

References (23)

1. Belkaid Y (2007) Regulatory T cells and infection: a dangerous necessity. Nat Rev 7:875-88 (Pubitemid 350006238)
2. Bour H, Peyron E, Gaucherand M et al. (1995) Major histocompatibility complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. Eur J Immunol 25:3006-10
3. Dubois B, Chapat L, Goubier A et al. (2003) Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102:3295-301 (Pubitemid 37314769)
4. Gorbachev AV, Fairchild RL (2001) Induction and regulation of T-cell priming for contact hypersensitivity. Crit Rev Immunol 21:451-72 (Pubitemid 34259915)
5. Hanafusa T, Azukizawa H, Kitaba S et al. (2011) Diminished regulatory T cells in cutaneous lesions of thymoma-associated multi-organ autoimmunity: a newly described paraneoplastic autoimmune disorder with fatal clinical course. Clin Exp Immunol 166:164-70
6. Honda T, Otsuka A, Tanizaki H et al. (2011) Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase. J Dermatol Sci 61:144-7
7. Kish DD, Gorbachev AV, Fairchild RL (2005) CD8+ T cells produce IL-2, which is required for CD(4+)CD25+ T cell regulation of effector CD8+ T cell development for contact hypersensitivity responses. J Leukoc Biol 78:725-35 (Pubitemid 41292095)
8. Klarquist J, Denman CJ, Hernandez C et al. (2010) Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res 23:276-86
9. Lahl K, Loddenkemper C, Drouin C et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204:57-63 (Pubitemid 46148756)
10. Lehto M, Haapakoski R, Wolff H et al. (2005) Cutaneous, but not airway, latex exposure induces allergic lung inflammation and airway hyperreactivity in mice. J Invest Dermatol 125:962-8
11. Lin W, Truong N, Grossman WJ et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116:1106-15 (Pubitemid 41571796)
12. Nuriya S, Enomoto S, Azuma M (2001) The role of CTLA-4 in murine contact hypersensitivity. J Invest Dermatol 116:764-8 (Pubitemid 32467657)
13. Ring S, Oliver SJ, Cronstein BN et al. (2009) CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism. J Allergy Clin Immunol 123: 1287-96 e2
14. Schwarz A, Maeda A, Wild MK et al. (2004) Ultraviolet radiationinduced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J Immunol 172: 1036-43 (Pubitemid 38113763)
15. Shevach EM (2006) From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 25:195-201 (Pubitemid 44224153)
16. Tomura M, Honda T, Tanizaki H et al. (2010) Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 120:883-93
17. Traidl C, Merk HF, Cavani A et al. (2000) New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models. Skin Pharmacol Appl Skin Physiol 13:300-12
18. Vignali DA, Collison LW, Workman CJ (2008) How regulatory T cells work. Nat Rev 8:523-32
19. Wing K, Onishi Y, Prieto-Martin P et al. (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science (New York, NY 322:271-5
20. Wing K, Sakaguchi S (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11:7-13
21. Vocanson M, Hennino A, Rozieres A et al. (2009) Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 64:1699-714
22. Xu H, DiIulio NA, Fairchild RL (1996) T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. J Exp Med 183:1001-12
23. Ziegler SF (2006) FOXP3: of mice and men. Ann Rev Immunol 24:209-26