Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 6, 2012, Pages 729-737

  Michalski, Joel ^a   Kanaji, Nobuhiro ^c   Liu, Xiangde ^a   Nogel, Steve ^a   Wang, Xingqi ^a,b   Basma, Hesham ^a   Nakanishi, Masanori ^a   Sato, Tadashi ^e   Gunji, Yoko ^a   Fahrid, Maha ^a   Nelson, Amy ^a   Muller, Kai Christian ^d   Holz, Olaf ^f   Magnussen, Helgo ^d   Rabe, Klaus F ^d   Toews, Myron L ^a   Rennard, Stephen I ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b HEBEI UNITED UNIVERSITY   (China)

^c KAGAWA UNIVERSITY   (Japan)

^d KRANKENHAUS GROSSHANSDORF   (Germany)

^e JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

COPD; Desensitization; Fibroblast; PGE2

Indexed keywords

CYCLIC AMP; ILOPROST; PHOSPHODIESTERASE IV; PROSTAGLANDIN E2; SALBUTAMOL;

ARTICLE; CELL MIGRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; FETUS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG FIBROBLAST; PROTEIN DEGRADATION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; AMINOPYRIDINES; BENZAMIDES; CELLS, CULTURED; CHEMOTAXIS; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOPROPANES; DINOPROSTONE; FIBROBLASTS; FIBRONECTINS; FORSKOLIN; GENE EXPRESSION; HUMANS; ILOPROST; ISOENZYMES; LUNG; PHOSPHODIESTERASE 4 INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, PROSTAGLANDIN; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; ROLIPRAM; SECOND MESSENGER SYSTEMS;

EID: 84870486603     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0057OC     Document Type: Article

References (33)

1. Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol 2011;254:72-85.
2. Chen Y, Chen P, Hanaoka M, Droma Y, Kubo K. Enhanced levels of prostaglandin E2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD. Respirology 2008;13:1014-1021.
3. Montuschi P, Kharitonov SA, Ciabattoni G, Barnes PJ. Exhaled leukotrienes and prostaglandins in COPD. Thorax 2003;58:585-588.
4. Verhoeven GT, Garrelds IM, Hoogsteden HC, Zijlstra FJ. Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease. Mediators Inflamm 2001;10:21-26.
5. Chen Y, Chen P. [Expressions of cyclooxygenase-2 and matrix metalloproteinase-2 and airflow obstruction in patients with chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi 2005;28:324-327.
6. Horowitz JC, Martinez FJ, Thannickal VJ. Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema. COPD 2009;6:201-210.
7. Kohyama T, Ertl RF, Valenti V, Spurzem J, Kawamoto M, Nakamura Y, Veys T, Allegra L, Romberger D, Rennard SI. Prostaglandin E(2) inhibits fibroblast chemotaxis. Am J Physiol Lung Cell Mol Physiol 2001;281:L1257-L1263.
8. Li YJ, Wang XQ, Sato T, Kanaji N, Nakanishi M, Kim M, Michalski J, Nelson AJ, Sun JH, Farid M, et al. Prostaglandin E inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors. Am J Respir Cell Mol Biol 2011;44:99-107.
9. Togo S, Liu X, Wang X, Sugiura H, Kamio K, Kawasaki S, Kobayashi T, Ertl RF, Ahn Y, Holz O, et al. PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol 2009;296:L959-L969.
10. White ES, Atrasz RG, Dickie EG, Aronoff DM, Stambolic V, Mak TW, Moore BB, Peters-Golden M. Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol 2005;32:135-141.
11. Holz O, Zuhlke I, Jaksztat E, Muller KC, Welker L, Nakashima M, Diemel KD, Branscheid D, Magnussen H, Jorres RA. Lung fibroblasts from patients with emphysema show a reduced proliferation rate in culture. Eur Respir J 2004;24:575-579.
12. Bitterman PB, Wewers MD, Rennard SI, Adelberg S, Crystal RG. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J Clin Invest 1986;77:700-708.
13. Shimizu H, Daly JW, Creveling CR. A radioisotopic method for measuring the formation of adenosine 39,59-cyclic monophosphate in incubated slices of brain. J Neurochem 1969;16:1609-1619.
14. Kassel KM, Wyatt TA, Panettieri RA Jr, Toews ML. Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement. Am J Physiol Lung Cell Mol Physiol 2008;294:L131-L138.
15. Miniño AM, Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2008. Natl Vital Stat Rep 2011;59:1-126.
16. Wilson RJ, Rhodes SA, Wood RL, Shield VJ, Noel LS, Gray DW, Giles H. Functional pharmacology of human prostanoid EP2 and EP4 receptors. Eur J Pharmacol 2004;501:49-58.
17. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD. Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 2001;41:661-690.
18. Honda A, Sugimoto Y, Namba T, Watabe A, Irie A, Negishi M, Narumiya S, Ichikawa A. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J Biol Chem 1993;268:7759-7762.
19. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 1994;46:213-220.
20. Chen YJ, Wang T, Liu DS, Xu D, Chen L, An J, Wen FQ. Effect of budesonide on TGF-beta1-enhanced VEGF production by lung fibroblasts. Cell Biol Int 2010;34:777-782.
21. Petecchia L, Sabatini F, Usai C, Carnevali S, Ognibene M, Vanni C, Eva A, Fabbri LM, Rossi GA, Ricciardolo FL. Mechanisms of bradykinininduced contraction in human fetal lung fibroblasts. Eur Respir J 2010;36:655-664.
22. Kohyama T, Yamauchi Y, Takizawa H, Kamitani S, Kawasaki S, Nagase T. Histamine stimulates human lung fibroblast migration. Mol Cell Biochem 2010;337:77-81.
23. Yang Z, Zhu X, Guo C, Sun K. Stimulation of 11beta-HSD1 expression by IL-1beta via a C/EBP binding site in human fetal lung fibroblasts. Endocrine 2009;36:404-411.
24. Antoniu SA. New therapeutic options in the management of COPD: focus on roflumilast. Int J Chron Obstruct Pulmon Dis 2011;6:147-155.
25. Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, et al. Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med 2008;178:248-260.
26. Nyunoya T, Monick MM, Klingelhutz A, Yarovinsky TO, Cagley JR, Hunninghake GW. Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol 2006;35:681-688.
27. Muller KC, Paasch K, Feindt B, Welker L, Watz H, Weise M, Schmid RA, Nakashima M, Branscheid D, Magnussen H, et al. In contrast to lung fibroblasts: no signs of senescence in skin fibroblasts of patients with emphysema. Exp Gerontol 2008;43:623-628.
28. Nobukuni S, Watanabe K, Inoue J, Wen FQ, Tamaru N, Yoshida M. Cigarette smoke inhibits the growth of lung fibroblasts from patients with pulmonary emphysema. Respirology 2002;7:217-223.
29. Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD Executive Summary. Am J Respir Crit Care Med (In press)
30. Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 1995;95:1861-1868.
31. Borok Z, Gillissen A, Buhl R, Hoyt RF, Hubbard RC, Ozaki T, Rennard SI, Crystal RG. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am Rev Respir Dis 1991;144:1080-1084.
32. Moore BB, Ballinger MN, White ES, Green ME, Herrygers AB, Wilke CA, Toews GB, Peters-Golden M. Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. J Immunol 2005;174:5644-5649.
33. Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC, Peters-Golden M. Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice. Am J Pathol 2010;177:2245-2255.