Effect of budesonide on TGF-β1-enhanced VEGF production by lung fibroblasts

Cell Biology International

Volumn 34, Issue 7, 2010, Pages 777-782

  Chen, Ya Juan ^a   Wang, Tao ^a   Liu, Dai Shun ^a   Xu, Dan ^a   Chen, Lei ^a   An, Jing ^a   Wen, Fu Qiang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Airway remodelling; Budesonide; Extracellular signal regulated kinase; Smad3; Transforming growth factor 1; Vascular endothelial growth factor

Indexed keywords

BUDESONIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHO SMAD3 PROTEIN; SMAD PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; GLUCOCORTICOID; VASCULOTROPIN A;

ARTICLE; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; FIBROBLAST; LUNG; METABOLISM;

ANIMALS; BUDESONIDE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GLUCOCORTICOIDS; HUMANS; LUNG; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77955332748     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090083     Document Type: Article

References (23)

1. Andrew L, David JA. TGF-β signaling and the fibrotic response. FASEB J 2004;18:816-23.
2. Alexei G, Kzhyshkowska J, Kannookadan S, Ochsenreiter M, Popova A, Yu XL et al. Activation of a TGF-b-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-b receptor II. J Immunol 2008;180:6553-65.
3. Bandi N, Kompella UB. Budesonide reduces vascular endothelial growth factor secretion and expression in airway (Calu-1) and alveolar (A549) epithelial cells. Eur J Pharmacol 2001;425:109-16.
4. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-b family signaling. Nature 2003;425:577-84.
5. Dong Q, Lin HY, Wang HM, Zhang X, Liu DL, Li QL et al. Involvement of ERK1/2 Pathway in TGF-b1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev 2004;68:198-204.
6. Funaba M, Zimmerman CM, Mathews LS. Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. J Biol Chem 2002;277:41361-8.
7. Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT. Mechanisms underlying TGF-b1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. J Leukoc Biol 2007;81:557-66.
8. Kang HR, Cho SJ, Chun GL, Robert JH, Jack AE. Transforming growth factor (TGF)-b1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, Bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem 2007;282:7723-32.
9. Kobayashi T, Liu XD, Wen FQ, Fang QH, Shinji A, Wang XQ et al. Smad3 mediates TGF-b1 induction of VEGF production in lung fibroblasts. Biochem Biophys Res Commun 2005;327:393-98.
10. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
11. Massagué J. TGF-b in cancer. Cell 2008;134:215-30.
12. Mastruzzo C, Greco LR, Nakano K, Nakano A, Palermo F, Pistorio MP et al. Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammation. J Allergy Clin Immunol 2003;112:37-44.
13. McMillan SJ, Xanthou G, Lloyd CM. Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling. Clin Exp Allergy 2005;35:388-96.
14. Michael R, Peter RA, Michel PB, Jochen JR, Gregory GK, Ge Q et al. Dysfunctional interaction of C/EBPa and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N Engl J Med 2004;351:560-74.
15. O'Byrne PM, Bisgaard H, Godard PP, Massimo P, Palmqvist M, Zhu YJ et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005;171:129-36.
16. Ou XM, Li WC, Liu DS, Li YP, Wen FQ, Feng YL et al. VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice. Int Immunopharmacol 2009;9:70-9.
17. Reisdorf P, Lawrence DA, Sivan V, Klising E, Martin MT. Alteration of transforming growth factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis. Am J Pathol 2001;159:263-72.
18. Reynold AP, Michael IK, William TG, Marc BH, Prescott GW, Ian PH et al. Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am J Respir Crit Care Med 2008;177:248-52.
19. Southam DS, Ellis R, Wattie J, Young SI. Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice. Eur Respir J 2008;32:970-8.
20. Turk R, John AC. Anti-inflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005;353:1711-23.
21. 2 cytokine-enhanced and TGF-b-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-c and corticosteroids. J Allergy Clin Immunol 2003;111:1307-18.
22. Wen FQ, Skold CM, Liu XD, Ertl RF, Zhu YK, Kohyama Tet al. Glucocorticoids and TGF-beta1 synergize in augmenting fibroblast mediated contraction of collagen gels. Inflammation 2001;25:109-17.
23. Yue J, Mulder KM. Activation of the mitogen-activated protein kinase pathway by transforming growth factor-b. Methods Mol Biol 2000;142:125-31.