The monocyte chemoattractant protein-1 (MCP-1)/CCR2 system is involved in peritoneal dialysis-related epithelial-mesenchymal transition of peritoneal mesothelial cells

Laboratory Investigation

Volumn 92, Issue 12, 2012, Pages 1698-1711

  Lee, Sun Ha ^a   Kang, Hye Young ^a   Kim, Kyung Sik ^a   Nam, Bo Young ^a   Paeng, Jisun ^a   Kim, Seonghun ^a   Li, Jin Ji ^a,b   Park, Jung Tak ^a   Kim, Dong Ki ^c   Han, Seung Hyeok ^a   Yoo, Tae Hyun ^a   Kang, Shin Wook ^a  

^a Yonsei University   (South Korea)

^b YANBIAN UNIVERSITY MEDICAL COLLEGE   (China)

^c Seoul National University Hospital   (South Korea)

Author keywords

epithelial mesenchymal transition; monocyte chemoattractant protein 1; peritoneal fibrosis; peritoneal mesothelial cells; transforming growth factor 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBRONECTIN; GLUCOSE; MONOCYTE CHEMOTACTIC PROTEIN 1; SODIUM CHLORIDE; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATHETER; CONTROLLED STUDY; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MESOTHELIUM CELL; MUTANT; NONHUMAN; PERITONEAL DIALYSIS; PERITONEAL MESOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; CELLS, CULTURED; CHEMOKINE CCL2; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FIBRONECTINS; GLUCOSE; HEK293 CELLS; HUMANS; MALE; PERITONEAL DIALYSIS; PERITONEAL FIBROSIS; PERITONEUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84870422141     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.132     Document Type: Article

References (37)

1. Nesrallah G, Mendelssohn DC. Modality options for renal replacement therapy: the integrated care concept revisited. Hemodial Int 2006;10:143-151.
2. Krediet RT, Lindholm B, Rippe B. Pathophysiology of peritoneal membrane failure. Perit Dial Int 2000;20(Suppl 4):S22-S42.
3. Dobbie JW. Pathogenesis of peritoneal fibrosing syndromes (sclerosing peritonitis) in peritoneal dialysis. Perit Dial Int 1992;12: 14-27.
4. Yanez-Mo M, Lara-Pezzi E, Selgas R, et al. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 2003;348:403-413.
5. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119:1420-1428.
6. Aroeira LS, Aguilera A, Sanchez-Tomero JA, et al. Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 2007;18: 2004-2013.
7. Yang AH, Chen JY, Lin JK. Myofibroblastic conversion of mesothelial cells. Kidney Int 2003;63:1530-1539.
8. Margetts PJ, Bonniaud P, Liu L, et al. Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005;16:425-436.
9. Segerer S, Nelson PJ, Schlondorff D. Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000;11:152-176.
10. Chow FY, Nikolic-Paterson DJ, Ozols E, et al. Monocyte chemo-attractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice. Kidney Int 2006;69:73-80.
11. Wada T, Furuichi K, Sakai N, et al. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. J Am Soc Nephrol 2004;15:940-948.
12. Xu J, Lin SC, Chen J, et al. CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis. Am J Physiol Heart Circ Physiol 2011;301:H538-H547.
13. Topley N, Liberek T, Davenport A, et al. Activation of inflammation and leukocyte recruitment into the peritoneal cavity. Kidney Int Suppl 1996;56:S17-S21.
14. Giunti S, Pinach S, Arnaldi L, et al. The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 2006;69:856-863.
15. Urushihara M, Ohashi N, Miyata K, et al. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Hypertension 2011;57:586-593.
16. Kang YS, Lee MH, Song HK, et al. CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kidney Int 2010;78:883-894.
17. Park J, Ryu DR, Li JJ, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol 2008;295: F749-F757.
18. Nam BY, Paeng J, Kim SH, et al. The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions. Apoptosis 2012;17:1-13.
19. Giunti S, Tesch GH, Pinach S, et al. Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells. Diabetologia 2008;51:198-207.
20. Schneider A, Panzer U, Zahner G, et al. Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulone-phritis by transforming growth factor-beta. Kidney Int 1999;56: 135-144.
21. Wolf G, Jocks T, Zahner G, et al. Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Am J Physiol Renal Physiol 2002;283:F1075-F1084.
22. Gruden G, Setti G, Hayward A, et al. Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. J Am Soc Nephrol 2005; 16:688-696.
23. Stylianou E, Jenner LA, Davies M, et al. Isolation, culture and characterization of human peritoneal mesothelial cells. Kidney Int 1990;37:1563-1570.
24. Zhang YJ, Rutledge BJ, Rollins BJ. Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis. J Biol Chem 1994;269: 15918-15924.
25. Musi B, Braide M, Carlsson O, et al. Biocompatibility of peritoneal dialysis fluids: long-term exposure of nonuremic rats. Perit Dial Int 2004;24:37-47.
26. Loureiro J, Schilte M, Aguilera A, et al. BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure. Nephrol Dial Transplant 2010;25: 1098-1108.
27. Lv ZD, Na D, Ma XY, et al. Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ss1 in vitro. Int J Mol Med 2011;27:187-193.
28. Shook D, Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 2003;120: 1351-1383.
29. Xue C, Plieth D, Venkov C, et al. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 2003;63:3386-3394.
30. Zeisberg M, Kalluri R. The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med (Berl) 2004;82:175-181.
31. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210.
32. Hung KY, Huang JW, Chiang CK, et al. Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies. Nephrol Dial Transplant 2008;23: 3831-3840.
33. Zareie M, De Vriese AS, Hekking LH, et al. Immunopathological changes in a uraemic rat model for peritoneal dialysis. Nephrol Dial Transplant 2005;20:1350-1361.
34. Fabbrini P, Schilte MN, Zareie M, et al. Celecoxib treatment reduces peritoneal fibrosis and angiogenesis and prevents ultrafiltration failure in experimental peritoneal dialysis. Nephrol Dial Transplant 2009;24: 3669-3676.
35. Soria G, Ofri-Shahak M, Haas I, et al. Inflammatory mediators in breast cancer: coordinated expression of TNFalpha & IL-1beta with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer 2011;11:130.
36. Yu MA, Shin KS, Kim JH, et al. HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothe-lium. J Am Soc Nephrol 2009;20:567-581.
37. Kim DK, Nam BY, Li JJ, et al. Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes. Diabetologia 2012;55:1205-1217.