Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression

Journal of Applied Toxicology

Volumn 33, Issue 1, 2013, Pages 71-77

  Chen, Hong Li ^a   Bai, Hua ^a   Xi, Miao Miao ^b   Liu, Riu ^a   Qin, Xu Jun ^a   Liang, Xin ^a   Zhang, Wei ^a   Zhang, Xiao Di ^a   Li, Wen Li ^a   Hai, Chun Xu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cyclooxygenase2; Ethyl pyruvate; Inducible nitric oxide synthas; Mitogen activated protein kinases; Phosgene; Pulmonary edema

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRITE; PHOSGENE; PROSTAGLANDIN E2; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LOWER RESPIRATORY TRACT; LUNG EDEMA; LUNG LAVAGE; LUNG WEIGHT; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; WESTERN BLOTTING;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CHEMICAL WARFARE AGENTS; CYCLOOXYGENASE 2; LUNG; MACROPHAGES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SIZE; PHOSGENE; PROTECTIVE AGENTS; PULMONARY EDEMA; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84870389261     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1713     Document Type: Article

References (47)

1. Babizhayev MA, Deyev AI. 2010. Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production. Am. J. Ther. [epub ahead of print]; DOI: 10.1097/MJT.0b013e3181dcf589.
2. Chan ED, Riches, DW. 2001. IFN-gamma+LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38 (mapk) in a mouse macrophage cell line. Am. J. Physiol. Cell Physiol. 280: C441-C450.
3. Chen HL, Hai CX, Liang X, Zhang XD, Liu R, Qin XJ. 2009. Correlation between sPLA2-IIA and phosgene-induced rat acute lung injury. Inhal. Toxicol. 21: 374-380; DOI: 10.1080/08958370802449712.
4. Chen Y, Yang C. 2009. Bradykinin induces COX-2 expression via MAPKs and NF-{kappa}B in human synovial fibroblast of rheumatoid arthritis. FASEB J. 23: 941-943.
5. Cruz R, Quintana-Hau JD, Gonzalez JR, Tornero-Montano R, Baiza-Duran LM, Vega L. 2008. Effects of an ophthalmic formulation of meloxicam on COX2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. Br. J. Ophthalmol. 92: 120-125; DOI: 10.1136/bjo.2007.125179.
6. Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, Serraino I, Britti D, Mazzullo G, Caputi AP, Thiemermann C. 2002. Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br. J. Pharmacol. 135: 496-510; DOI: 10.1038/sj.bjp.0704463.
7. Di Paola R, Mazzon E, Genovese T, Crisafulli C, Bramanti P, Caminiti R, Esposito E, Fink MP, Cuzzocrea S. 2009. Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice. Crit. Care Med. 37: 270-282; DOI: 10.1097/CCM.0b013e318192fa63.
8. Duniho SM, Martin J, Forster JS, Cascio MB, Moran TS, Carpin LB, Sciuto AM. 2002. Acute changes in lung histopathology and bronchoalveolar lavage parameters in mice exposed to the choking agent gas phosgene. Toxicol. Pathol. 30: 339-349.
9. Ehmke H, Kurtz A. 2003. Deciphering the physiological roles of COX-2. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284: R486-487; DOI: 10.1152/ajpregu.00680.2002.
10. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips GB, Parkinson JF, Cox R, Hawkins H, Herndon D, Traber D. 2003. The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am. J. Respir. Crit. Care Med. 167: 1021-1026; DOI: 10.1164/rccm.200209-1031PP.
11. Fitzgerald GJ. 2008. Chemical warfare and medical response during World War I. Am. J. Public Health 98: 611-625; DOI: 10.2105/AJPH.2007.11930.
12. Goggel R, Hoffman S, Nusing R, Narumiya S, Uhlig S. 2002. Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E (2), E-prostanoid 3-receptors, and potassium channels. Am. J. Respir. Crit. Care Med. 166: 657-662.
13. Grainge C, Rice P. 2010. Management of phosgene-induced acute lung injury. Clin. Toxicol. 48: 497-508; DOI: 10.3109/15563650.2010.506877.
14. Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, Harbrecht BG. 2002. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock 17: 98-103.
15. James MJ, Penglis PS, Caughey GE, Demasi M, Clelan LG. 2001. Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response? Inflamm. Res. 50: 249-253.
16. Klein E, Weigel J, Buford MC, Holian A, Wells SM. 2010. Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. Am. J. Physiol. Lung Cell. Mol. Physiol. 299: L816-25; DOI: 10.1152/ajplung.00188.2010.
17. Krysan K, Merchant FH, Zhu L, Dohadwala M, Luo J, Lin Y, Heuze-Vourc'H N, Pold M, Seligson D, Chia D, Goodglick L, Wang H, Strieter R, Sharma S, Dubinett S. 2004. COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J. 18: 206-208; DOI: 10.1096/fj.03-0369fje.
18. Kung CW, Lee YM, Cheng PY, Peng YJ, Yen MH. 2011. Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats. J. Surg. Res. 167: e323-e331; DOI: 10.1016/j.jss.2011.01.006.
19. Lai CS, Lee JH, Ho CT, Liu CB, Wang JM, Wang YJ, Pan MH. 2009. Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. J. Agric. Food Chem. 57: 10990-10998; DOI: 10.1021/jf9025713.
20. Laskin DL, Sunil VR, Fakhrzadeh L, Groves A, Gow AJ, Laskin JD. 2010. Macrophages, reactive nitrogen species, and lung injury. Ann. NY Acad. Sci. 1203: 60-65; DOI: 10.1111/j.1749-6632.2010.05607.x.
21. Lee J, Kwon W, Jo Y, Suh G, Youn Y. 2008. Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats. Hum. Exp. Toxicol. 27: 49-54; DOI: 10.1177/0960327108088976.
22. Lim SC, Yang JY, Jang AS, Park YU, Kim YC, Choi IS, Park KO. 1996. Acute lung injury after phosgene inhalation. Korean J. Intern. Med. 11: 87-92.
23. Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar Sr. 2008. Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages. Cell. Physiol. Biochem. 22: 279-286; DOI: 10.1159/000149806.
24. Meijer F, Van Delft JL, Garrelds IM, Van Haeringen NJ, Kijlstra A. 1996. Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis. Exp. Eye Res. 62: 359-365; DOI: 10.1006/exer.1996.0041.
25. Nagareddy PR, Xia Z, McNeill JH, MacLeod KM. 2005. Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes. Am. J. Physiol: Heart Circul. Physiol. 289(5): H2144-H2152; DOI: 10.1152/ajpheart.00591.2005.
26. Naidu BV, Fraga C, Salzman AL, Szabo C, Verrier ED, Mulligan M S. 2003. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. J. Heart Lung Transplant. 22: 784-793.
27. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. 2007. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal. Toxicol. 19: 789-810; DOI: 10.1080/08958370701479133.
28. Pfeilschifter J, Schalkwijk C, Briner VA, van den Bosch H. 1993. Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells. J. Clin. Invest. 92: 2516-2523; DOI: 10.1172/JCI116860.
29. Reade, M.C. and M.P. Fink. 2005. Bench-to-bedside review: amelioration of acute renal impairment using ethyl pyruvate. Crit. Care 9: 556-560; DOI: 10.1186/cc3892.
30. Sappington PL, Fink ME, Yang R, Delude RL, Fink MP. 2003. Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. Shock 20: 521-528; DOI: 10.1097/01.shk.0000092697.10326.8b.
31. Sciuto, AM. 2000. Posttreatment with ETYA protects against phosgene-induced lung injury by amplifying the glutathione to lipid peroxidation ratio. Inhal. Toxicol. 12: 374-356; DOI: 10.1080/089583700196194.
32. Sciuto AM, Moran TS. 2001. Effect of dietary treatment with n-propyl gallate or vitamin E on the survival of mice exposed to phosgene. J. Appl. Toxicol. 21: 33-39.
33. Sciuto AM, Stotts RR, Hurt HH. 1996. Efficacy of ibuprofen and pentoxifylline in the treatment of phosgene-induced acute lung injury. J. Appl. Toxicol. 16: 381-384; DOI: 10.1002/(SICI)1099-1263(199609)16:5<381::AID-JAT355>3.0.CO;2-8.
34. Sciuto AM, Lee RB, Forster JS, Cascio MB, Clapp DL, Moran TS. 2002. Temporal changes in respiratory dynamics in mice exposed to phosgene. Inhal. Toxicol. 14: 487-501; DOI: 10.1080/089583701753678580.
35. Sciuto AM, Carpin LB, Moran TS, Forster JS. 2003a. Chronological changes in electrolyte levels in arterial blood and bronchoalveolar lavage fluid in mice after exposure to an edemagenic gas. Inhal. Toxicol. 15: 663-674; DOI: 10.1080/08958370390197308.
36. Sciuto AM, Cascio MB, Moran TS, Forster JS. 2003b. The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7days in mice with acute lung injury. Inhal. Toxicol. 15: 675-685; DOI: 10.1080/08958370390197245.
37. Sciuto AM, Clapp DL, Hess Z A, Moran TS. 2003c. The temporal profile of cytokines in the bronchoalveolar lavage fluid in mice exposed to the industrial gas phosgene. Inhal. Toxicol. 15: 687-700; DOI: 10.1080/08958370390197254.
38. Seibert K, Masferrer JL. 1994. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 4: 17-23.
39. Shang GH, Lin DJ, Xiao W, Jia CQ, Li Y, Wang AH, Dong L. 2009. Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respir. Res. 10: 91; DOI: 10.1186/1465-9921-10-91.
40. Skidgel RA, Gao XP, Brovkovych V, Rahman A, Jho D, Predescu S, Standiford TJ, Malik AB. 2002. Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis. J. Immunol. 169: 2093-2101.
41. Solinska-Lewna B, Hermelin A. 2010. Phosgene poisoning: analysis of cases. Med. Pr. 61: 101-104.
42. Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE, Benschop R, Sparvero LJ, Amoscato AA, Tracey KJ, Zeh HJ, Lotze MT. 2010. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 29: 5299-5310; DOI: 10.1038/onc.2010.261.
43. Vause CV, Durham PL. 2009. CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways. J. Neurochem. 110: 811-821; DOI: 10.1111/j.1471-4159.2009.06154.x.
44. Wang CC, Choy CS, Liu YH, Cheah KP, Li JS, Wang JT, Yu WY, Lin CW, Cheng HW, Hu CM. 2010. Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages. J. Sci. Food Agric. 91: 218-225; DOI: 10.1002/jsfa.4172.
45. Xiang L, Hester RL, Fuller WL, Sebai ME, Mittwede PN, Jones EK, Aneja A, Russell GV. 2010. Orthopedic trauma-induced pulmonary injury in the obese Zucker rats. Microcirculation 17: 650-659; DOI: 10.1111/j.1549-8719.2010.00061.x.
46. Yang R, Gallo DJ, Baust JJ, Uchiyama T, Watkins SK, Delude RL, Fink MP. 2002. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am. J. Physiol. Gastrointest. Liver. Physiol. 283: G212-G221; DOI: 10.1152/agifi.00022.2002.
47. Zhang W, Liu HT. 2002. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12: 9-18; DOI: 10.1038/sj.cr.7290105.