Hits identified in library screening demonstrate selective CYP17A1 lyase inhibition

Journal of Steroid Biochemistry and Molecular Biology

Volumn 134, Issue 1, 2013, Pages 75-79

  Krug, Sebastian J ^a   Hu, Qingzhong ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Androgens; CYP17A1; Hydroxylase assay; Lyase assay; Prostate cancer; Selectivity screening

Indexed keywords

ABIRATERONE; ANDROGEN; ANTINEOPLASTIC AGENT; CORTICOSTEROID; CYTOCHROME P450 1A1; LYASE INHIBITOR; STEROID 17ALPHA MONOOXYGENASE;

ANDROGEN SYNTHESIS; ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PROCESSING; STEROIDOGENESIS;

ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; PROSTATIC NEOPLASMS; SMALL MOLECULE LIBRARIES; STEROID 17-ALPHA-HYDROXYLASE;

EID: 84870383585     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2012.10.019     Document Type: Article

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