Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice

Journal of Physiology

Volumn 590, Issue 23, 2012, Pages 6187-6197

  Yamada, Takashi ^a   Ivarsson, Niklas ^a   Hernández, Andrés ^a   Fahlström, Andreas ^a   Cheng, Arthur J ^a   Zhang, Shi Jin ^a   Bruton, Joseph D ^a   Ulfhake, Brun ^a   Westerblad, Håkan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE; CYTOCHROME C OXIDASE; DNA POLYMERASE; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CALCIUM CELL LEVEL; CONTROLLED STUDY; DISEASE RESISTANCE; DISEASE SEVERITY; DNA DETERMINATION; ENZYME ACTIVITY; FAST MUSCLE; INTRACELLULAR SIGNALING; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE CELL; MUSCLE DISEASE; MUSCLE FATIGUE; MUSCLE FIBRIL; MUSCLE TETANIC CONTRACTION; MUSCLE WEAKNESS; NONHUMAN; OXIDATION; PATHOGENESIS; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SKELETAL MUSCLE; STEADY STATE;

AGING, PREMATURE; ANIMALS; CALCIUM; DNA, MITOCHONDRIAL; MICE; MICE, MUTANT STRAINS; MITOCHONDRIA, MUSCLE; MUSCLE FATIGUE; MUSCLE WEAKNESS; MUSCLE, SKELETAL; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM;

EID: 84870373755     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.240077     Document Type: Article

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